Results 171 to 180 of about 7,410,472 (247)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

A Study on Changes in Serum HMGB1/RAGE Pro-Inflammatory Axis and Related Cytokines Levels in Patients with Acute Brucellosis in Qinghai Province, China. [PDF]

Trop Med Infect Dis
Chen Y, Wang J, Li Q, Zhao Y, Xue H, Li J, Zhao C, Ma L, Li S, Tang S, Chen X, Zhao Z.   +11 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Longitudinal Analysis of Reproductive and Adrenal Hormones in Bontebok (<i>Damaliscus pygargus pygargus</i>). [PDF]

Animals (Basel)
Scarlata CD, Westcott LBF, Suhn M, Wielebnowski N.   +3 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

The shifting landscape of brain-wide myelination across the human lifespan. [PDF]

Nat Commun
Ahmad S, Huynh KM, Lin G, Yap PT.
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Early Life Ambient Air Pollution and Child Neurodevelopment: Critical Review of Cohort Evidence. [PDF]

J Xenobiot
Al-Atram AA, Elkossi M, Aly SE, Ahmad AR, Temsah MH, Afifi WA, Saad K.   +6 more
europepmc   +1 more source

Personality development from early to middle adulthood in the general population and those with mental health difficulties. [PDF]

Sci Rep
Kerr JA, Dashti SG, Husin HM, Spry EA, Sawyer SM, Moran P, Monk-Cunliffe J, Patton GC, Olsson CA.   +8 more
europepmc   +1 more source