Results 241 to 250 of about 1,357,390 (361)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Proteomic Signatures Over Age Reveal Significant Changes From Infancy Till Late Adulthood. [PDF]

Adv Biol (Weinh)
Delemarre EM, Smits HM, van Baarle D, van Houten MA, van der Klis FRM, Leavis HL, van Roon JAG, Verhagen LM, Wildenbeest JG, van Wijk F, Drylewicz J, Nierkens S.   +11 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Middle Pleistocene tectonic events around the SE Aegean Sea: Insights from magnetostratigraphy, (U-Th)/He zircon dating, and fault kinematics in the Datça Graben (SW Türkiye). [PDF]

Sci Rep
İnce MD, Kaymakci N, Langereis C, Uzel B, Gülyüz E, Koralay EO, Stoica M, Sümer Ö.   +7 more
europepmc   +1 more source

Si una noche de invierno un canónigo… Por una historia nocturna de las élites urbanas en el tránsito del Medievo a la Modernidad: materiales ovetenses para una primera tentativa ( If on a winter’s night a canon... Towards a nocturnal history of urban elites in the transition from the Middle Ages to the Early Modernity: A fi rst attempt based on documentary evidence from the town of Oviedo ) [PDF]

, 2014
Raúl González González
openalex  

From the Circle of Alcuin to the School of Auxerre: Logic, Theology, and Philosophy in the Early Middle Ages (review)

, 1983
Paul Vincent Spade
openalex   +2 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Age-dependent variations in aerosol-borne particulates and microbial communities in multi-tier broiler housing systems: A metagenomics environmental health risk assessment. [PDF]

Poult Sci
Liu X, Ma T, Khan I, Chen L, Zhang H.
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Éléments de chronologie des décors à la molette médiévaux en Midi-Pyrénées

Archéopages
Jean Catalo
doaj   +1 more source