Results 51 to 60 of about 8,175,990 (296)
E-REA, 2020 Conventual life in the early modern English communities in exile strictly observed the Rule and Constitutions which governed each house. These not only set out in great detail how every part of the day was to be spent but specified the spirit in which ...
Caroline BOWDEN
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Involuntary Separations: Catholic Wives, Imprisoned Husbands, and State Authority
Genealogy, 2022 In the 1580s and 1590s, the English state required that all subjects of the crown attend the Protestant state church. Those who refused (called recusants) faced imprisonment as part of the government’s attempt to bring them into religious conformity ...
Susan M. Cogan
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Devotions in the Ancient Way of Offices: Medieval Domestic Devotion in the Seventeenth Century
Religions, 2019 Devotions in the Ancient Way of Offices was first published as a Catholic primer for worship between intimates, then reformed for individual Protestant worship, and then reformed again for Protestant worship between intimates. Each adaptation engages the
Jantina Ellens
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Time and Temporality in the Early Modern Low Countries
, 2023 Introduction to the special issue 'Time and Temporality in the Early Modern Low Countries'
Deseure, Brecht +5 more
core +1 more source
History, 2006 Books reviewed:Richard L. Kagan and Abigail Dyer (Edited and translated), Inquisitorial Inquiries: Brief Lives of Secret Jews and Other Heretics.Robert C. Davis, Christian Slaves, Muslim Masters: White Slavery in the Mediterranean, the Barbary Coast, and Italy, 1500–1800.Christopher F. Black, Church, Religion and Society in Early Modern Italy.D. Dymond
openaire +2 more sources