Results 81 to 90 of about 38,188 (301)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Ontogeny of the Osmoregulatory Capacity of Teleosts and the Role of Ionocytes [PDF]

, 2020
Whilst osmoregulation in the adult teleost fish has been extensively studied and significant advances have been made in recent years, much less information exists regarding osmoregulation during the early stages of development of teleosts.
Fridman, Sophie
core   +1 more source

Complex and diverse patterns of neurocranial development in Australopithecus, Paranthropus and Homo

Scientific Reports
Even though poorly understood, early ontogeny may have influenced the distinct morphologies and behaviors of Homo sapiens, fossil hominins and extant African apes.
José Braga, Z. Alemseged, E. Gilissen
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tooth replacement in the early-diverging neornithischian Jeholosaurus shangyuanensis and implications for dental evolution and herbivorous adaptation in Ornithischia

BMC Ecology and Evolution
Background Tooth replacement patterns of early-diverging ornithischians, which are important for understanding the evolution of the highly specialized dental systems in hadrosaurid and ceratopsid dinosaurs, are poorly known.
Jinfeng Hu, Xing Xu, Fuqiang Li, Fenglu Han   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils

, 2008
Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR. Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils.
Teuchert-Noodt, Gertraud, Moll, Gunther H., Susanne Brummelte, Gertraud Teuchert-Noodt, Ralph R Dawirs, Dawirs, Ralph R., Gunther H Moll, Grund, Thorsten, Thorsten Grund, Brummelte, Susanne   +9 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Early-life sexual segregation: Ontogeny of isotopic niche differentiation in the Antarctic fur seal

, 2016
Early-life sexual segregation: Ontogeny of isotopic niche differentiation in the Antarctic fur ...
L Kernaléguen (13538641), B Cazelles (13661032), P Richard (13596838), John Arnould (13075095), C Guinet (13284966), Y Cherel (13290471)   +5 more
core  

Helping, fast and slow: Exploring intuitive cooperation in early ontogeny

, 2020
Cooperative behavior is central to human societies. Human adults who reach their cooperative decisions more rapidly and independently of cognitive control display greater levels of prosocial behavior.
Missana, M., Vaish, A., Grossmann, T.
core   +1 more source