Results 51 to 60 of about 5,993,784 (279)

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Laboratory early warning score versus clinical early warning score as a predictor of imminent cardiac arrest [PDF]

Critical Care, 2014
NCEPOD reported in 2012 that 75% of patients had warning signs for cardiac arrest present prior to their arrest [1]. NICE recommends a vital sign-based early warning score (EWS) to identify patients at risk of deterioration or death [2]. In our trust, audit has shown that only 20 to 35% of patients trigger the clinical EWS prior to cardiac arrest ...
Keil, M, Hutchinson, S, Leary, T
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Explicit Modeling and Visualization of Imperfect Information in the Context of Decision Support for Tsunami Early Warning in Indonesia [PDF]

, 2011
A certainty model and appropriate visualization techniques are presented which are applied in a newly developed Decision Support System (DSS) for tsunami early warning deployed in Jakarta, Indonesia.
Raape, Ulrich, Schoeckel, Thorsten, Friedemann, Monika, Sven Tessmann, Monika Friedemann, Thorsten Schoeckel, Strobl, Christian, Teßmann, Sven, Ulrich Raape, Christian Strobl   +9 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Malaria epidemic early warning and detection in African highlands. [PDF]

, 2004
Malaria epidemics have long been known to recur in the African highlands. Efforts to develop systems of early warning and detection for epidemics are outlined here with special emphasis on the Highland Malaria Project (HIMAL).
de Vlas, SJ, de Vlas, Sake, Cox, J, Ochola, Samuel, Beard, B, Langi, Peter, Cox, Jonathan, Langi, P, Hay, Simon I, Abeku, TA, Beard, Brian, Ochola, S, Hay, SI, Abeku, Tarekegn A, Hay, Simon, de Vlas, Sake J   +15 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

From scores to signals: evolution and innovations in pediatric early warning systems [PDF]

Acute and Critical Care
Early identification of clinical deterioration in hospitalized children is essential to improve outcomes and prevent critical events. Over the past two decades, structured approaches such as pediatric early warning scores and rapid response systems have ...
Wonjin Jang, Bongjin Lee
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source