Results 131 to 140 of about 502,399 (219)

Continuous UV irradiation played an inconclusive role in selecting the canonical genetic alphabet. [PDF]

Proc Natl Acad Sci U S A
Jusino-Maldonado M, Platten WC, Wolfe HJ, Todd ZR.   +3 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Mathematics Partial Associations with Subject-Specific Science Confidence: Evidence from 11 Education Systems in TIMSS 2023. [PDF]

Behav Sci (Basel)
Sideridis GD, Alghamdi M.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Magnetic resonance searches for Earth-sourced exotic nuclear spin-dependent interactions. [PDF]

Sci Adv
Wang Y, Huang X, Li J, Wang W, Kang X, Liu Y, Cong L, Budker D, Jiang M, Peng X.   +9 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

The ocean: a key Earth system regulator with boundaries. [PDF]

Natl Sci Rev
Mathesius S, Kaiser J, Ödalen M, Rockström J, Sakschewski B, Caesar L.   +5 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

The structure of a complex, asymmetric coronal mass ejection revealed by 17 spacecraft across the inner heliosphere. [PDF]

Sci Adv
Luspay-Kuti A, Turner DL, Paouris E, Vourlidas A, Crew AB, McNutt RL, Westlake JH, Raptis S, Cochrane CJ, Jia X, Raymond CA, Korth H, Heyner D, Hanley K, Rahmati A, Gruesbeck JR, Halekas JS, Curry SM, Smith HT, Stevens ML, Roussos E, Mandt KE, Kivelson MG, Slavin JA, Waller D, Khurana KK, Nordheim TA, Paty CS, Rymer AM, Saur J, Krupp N.   +30 more
europepmc   +1 more source