Results 61 to 70 of about 68,784 (262)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Off-grid photovoltaic system design for on-board blue swimming crab streamer processing and cold storage: System design and simulation [PDF]

BIO Web of Conferences
Blue swimming crab (BSC) catch is considered a highly perishable product; initial on-board processing, including steaming and cool preservation, is necessary to maintain quality.
Kuncoro Ari, Setiawan Ahmad Agus, Natsir Moh, Wisnugroho Susilo, Sasmita Suparman, Setiyobudi Nanang, Zarochman, Sukoraharjo Sri Suryo, Wassahua Zainal, Permana Sofiyan Muji, Sari Rodiah Nurbaya, Nugroho Kuncoro Catur, Nugraha Bambang Arif   +12 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Benefit of Unsaturated Soil Mechanics Approach on the Modeling of Early-Age Behavior of Rammed Earth Building. [PDF]

Materials (Basel), 2022
Chauhan P, Prime N, Plé O.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Locomotion and the early Mesozoic success of Archosauromorpha

Royal Society Open Science
The Triassic was a time of ecological upheaval as life recovered from the Permian-Triassic mass extinction. Archosauromorphs were a key component of the recovery, diversifying substantially during the Triassic and encompassing the origins of dinosaurs ...
Amy E. Shipley, Armin Elsler, Suresh A. Singh, Thomas L. Stubbs, Michael J. Benton   +4 more
doaj   +1 more source

A Review of CO2-Enhanced Oil Recovery with a Simulated Sensitivity Analysis

Energies, 2016
This paper reports on a comprehensive study of the CO2-EOR (Enhanced oil recovery) process, a detailed literature review and a numerical modelling study.
Mandadige Samintha Anne Perera, Ranjith Pathegama Gamage, Tharaka Dilanka Rathnaweera, Ashani Savinda Ranathunga, Andrew Koay, Xavier Choi   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Improvement of Mechanical Properties of Compressed Earth Blocks with Stabilising Additives for Self-Build of Sustainable Housing

Buildings
Earth building technologies are increasingly being used to promote a natural and sustainable construction model and to empower self-building in resource-limited areas. This work focuses on investigating the use of different types of stabilising additives
Jorge López-Rebollo, Xavier Cárdenas-Haro, Juan Pablo Parra-Vargas, Kevin Narváez-Berrezueta, Julver Pino   +4 more
doaj   +1 more source

Frost Resilience of Stabilized Earth Building Materials

Geosciences, 2019
Earth-based building materials are increasingly valued in green design for their low embodied energy, humidity-buffering ability, and thermal stability. These materials perform well in warm dry climates, but greater understanding of long-term durability ...
Alan W. Rempel, Alexandra R. Rempel
doaj   +1 more source