Results 91 to 100 of about 1,042,122 (308)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Applied SciencesUnderstanding the mechanical responses of layered rock masses at both macro and micro scales, particularly under diverse confining pressures and bedding directions, is crucial for evaluating their stability and optimizing resource extraction.
Xin Liu +5 more
doaj +1 more source
Satellite power system: Concept development and evaluation program, reference system report [PDF]
The Satellite Power System (SPS) Reference System is discussed and the technical and operational information required in support of environmental, socioeconomic, and comparative assessment studies are emphasized.
core +1 more source
Relativistic Corrections for Time and Frequency Transfer in Optical Fibres
, 2015 We derive relativistic corrections for one-way and two-way time and frequency transfer over optical fibres neglecting no terms that exceed 1 ps in time and $10^{-18}$ in fractional frequency, and estimate their magnitude in typical fibre links.
Delva, P, Geršl, J, Wolf, P
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
ArdethMud-domed houses in northern Syria represent a living architecture shaped by fragility, care, and cyclical renewal. Rather than relying on permanence, their resilience is rooted in ease of repair, material intelligence, and cultural practices of ...
Wesam Al Asali, Iyas Shahin
doaj
Argon ion pollution of the magnetosphere [PDF]
, 1985 Construction of a Solar Power Satellite (SPS) would require the injection of large quantities of propellant to transport material from Low Earth Orbit (LEO) to the construction site at Geostationary Earth Orbit (GEO).
Lopez, R. E.
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
BuildingsThis article documents the rammed earth construction practices undertaken at the “Tiles Hill–Xiangshan Campus Reception Centre” project. Traditional rammed earth craftsmanship is a sustainable construction method, with its core rooted in the precise ...
Lichao Chen +7 more
doaj +1 more source