Results 191 to 200 of about 7,326 (215)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Trophic Condition Shapes UVC Responses in <i>Euglena gracilis</i>. [PDF]

Life (Basel)
Sriwari S, Phinyo K, Prommana S, Intarasit S, Sriaporn C, Pekkoh J, Inwongwan S.   +6 more
europepmc   +1 more source

Health-carbon trade-offs in synergistic nitrogen governance. [PDF]

Eco Environ Health
Li R, Liu J, Luo Y, Li Y, Zhu X, Li H.
europepmc   +1 more source

Seasickness, Sea Legs, and Gravity: Suppression of Motion Sickness, Development of Sea Legs, The Role of the Striated Organelle in the Vestibular Efferent System. [PDF]

Audiol Res
Longridge NS, Mallinson AI.
europepmc   +1 more source

Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment. [PDF]

Nanomicro Lett
Jiang Q, Wang B, Cheng Y, Wang Y, Zhao H, Lu Y.   +5 more
europepmc   +1 more source

Non-Abrupt Vegetation Changes due to Altered Nutrient Balance Make Complex Scale-Dependent Warming and Cooling Effects. [PDF]

Glob Chang Biol
Hanggara B, El-Madany T, Carrara A, Moreno G, Gonzalez-Cascon R, Burchard-Levine V, Martin MP, Metzger S, Hildebrandt A, Reichstein M, Lee SC.   +10 more
europepmc   +1 more source

Lifecycle and circular economy assessment of bio based retrofitting strategies for heritage buildings using case studies from Iran, Oman and Saudi Arabia. [PDF]

Sci Rep
Ilbeigi BM, Alnejem M, Karimi M, Safaripoor S, Khalili F, Jahanshahi E, Hindasi YA.   +6 more
europepmc   +1 more source

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Earth's Energy Imbalance From the Ocean Perspective (2005–2019)

Geophysical Research Letters, 2021
M Z Hakuba, Thomas Frederikse, Felix W Landerer   +2 more
exaly