Results 61 to 70 of about 258,278 (245)
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Visualization analysis of ambient seismic noise research
Frontiers in Earth ScienceIn recent years, ambient seismic noise has gained considerable attention in seismology due to its potential to advance understanding of Earth’s subsurface dynamics and monitor anthropogenic activities.
Lihui Wu +4 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The future challenge of Earth science education research
Disciplinary and Interdisciplinary Science Education Research, 2019 This article addresses the question of what the future directions and emphases of the research in the earth science education field ought to be. During the past 30 years, Earth science education research has established a solid theoretical foundation, as
Nir Orion
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Editorial: Towards Improved Forecasting of Volcanic Eruptions
Frontiers in Earth Science, 2020 Corentin Caudron +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Dizhen xuebao地球科学是一门数据密集型学科，而知识图谱则被认为是充分利用和发挥地球科学领域庞大数据的一种有效方式。相对于通用大模型技术的发展，知识图谱能提供更为准确的知识，增强生成式大模型结果的智能性和可靠性。本文首先阐释了知识图谱的相关概念和构建方法；然后，对在科学领域广泛应用的顶层本体基本形式化本体模型进行了详细介绍，简单总结了地球科学领域已经建成的知识图谱，并着重论述了地球科学领域的地质学核心本体和地质科学本体，以及两者的异同；最后，介绍了与地球科学知识图谱构建相关的深时数字地球计划等国际地学数据科学计划 ...
Fenggui Niu, Bei Zhang, Shi Chen
doaj +1 more source