Results 31 to 40 of about 1,438,141 (312)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Dam-Breach hydrology of the Johnstown flood of 1889–challenging the findings of the 1891 investigation report

Heliyon, 2016
In 1891 a report was published by an ASCE committee to investigate the cause of the Johnstown flood of 1889. They concluded that changes made to the dam by the South Fork Fishing and Hunting Club did not cause the disaster because the embankment would ...
Neil M. Coleman, Uldis Kaktins, Stephanie Wojno   +2 more
doaj   +1 more source

Introducing Reproducibility to Citation Analysis: a Case Study in the Earth Sciences

Journal of eScience Librarianship, 2021
Objectives: Replicate methods from a 2019 study of Earth Science researcher citation practices. Calculate programmatically whether researchers in Earth Science rely on a smaller subset of literature than estimated by the 80/20 rule.
Samantha Teplitzky, Wynn Tranfield, Mea Warren, Philip White   +3 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Protocol for iron-catalyzed cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides

STAR Protocols
Summary: Organochlorides are a crucial class of electrophiles in organic synthesis. Here, we present a protocol for the cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides, facilitated by an iron/B2pin2 catalytic system.
Pengjie Xian, Hong Huang, Ruichen Zhang, Shasha Geng, Zhang Feng   +4 more
doaj   +1 more source

Integrating species-centric and geomorphic-centric views of interior least tern and piping plover habitat selection

Heliyon, 2018
The Federally endangered interior least tern (Sterna antillarum athalassos) and threatened piping plover (Charadrius melodus) nest on emergent sandbars in several braided rivers in the USA.
Jason M. Farnsworth, David M. Baasch, Patrick D. Farrell   +2 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Enhanced global extreme droughts driven by the Indian Ocean and Pacific Ocean on decadal timescales

iScience
Summary: In the 21st century, two record-breaking years of extreme drought coverage swept across the globe. These resulted in billions of agriculture losses and led to hunger and poverty in those developing countries.
Yihui Xu, Xiaodan Guan, Jianping Huang, Shi Jin, Zhiyuan Jin   +4 more
doaj   +1 more source

Basin classification and tectonic framework of the Nam Pat Group, Uttaradit Province, Thailand: Implications for the Nan Suture Zone

Heliyon, 2018
The Nam Pat Group of the Nam Pat Basin, Uttaradit Province, Thailand is situated in the Nan Suture Zone. Two contrasting tectonic framework models of the Nan Suture have previously been proposed: as a main Paleo-Tethyan suture and as a remnant of a ...
Kritsada Moonpa, Kannipa Motanated
doaj   +1 more source