Results 171 to 180 of about 249,122 (281)

Urban-rural consumption differences among the elderly in developed regions: Evidence from Zhejiang, China. [PDF]

PLoS One
Yin Y, Huang L, Han Q.
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Persistent river heatwaves are emerging worldwide under climate change. [PDF]

Nat Commun
Chen Y, Su Z, Woolway RI, Wanders N, Wu S, Huang Z, Luo M.   +6 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

K isotopes trace temporal silicate weathering intensity. [PDF]

Nat Commun
Gou LF, Sun H, Gu HO, Pogge von Strandmann PAE, Li W, Wilson DJ, Xiao J, Zhao ZQ, Galy A, Jin Z.   +9 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Climate and water-table levels regulate peat accumulation rates across Europe. [PDF]

PLoS One
Swindles GT, Mullan DJ, Brannigan NT, Fewster RE, Sim TG, Gallego-Sala A, Blaauw M, Lamentowicz M, Jassey VEJ, Marcisz K, Green SM, Roland TP, Loisel J, Amesbury MJ, Blundell A, Chambers FM, Charman DJ, Evans CRC, Feurdean A, Galloway JM, Gałka M, Karofeld E, Keaveney EM, Korhola A, Lamentowicz Ł, Langdon P, Mauquoy D, McKeown MM, Mitchell EAD, Plunkett G, Roe HM, Turner TE, Sillasoo Ü, Väliranta M, van der Linden M, Warner B.   +35 more
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Conceptions of geography teaching: Dataset enabling typology transfer and teaching quality reflection in other fields. [PDF]

Data Brief
Knecht P, Spurná M, Soukup P.
europepmc   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source