Results 171 to 180 of about 16,433 (224)

Precipitation observing network gaps limit climate change impact assessment. [PDF]

Nature
Su J, Miao C, Zwiers F, Beck H, Jones P, Sun Q, Slater LJ, Berghuijs WR, Wada Y, Rosenfeld D, Gou J, Wu Y, Tarolli P, Borrelli P, Panagos P, Alexander LV, Zhang Q, Hu J, Min SK, Samaniego L, Duan Q, Destouni G, Marengo JA, Modarres R, Sorooshian S.   +24 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Unprecedented Burning in Tropical Peatlands During the 20th Century Compared to the Previous Two Millennia. [PDF]

Glob Chang Biol
Wang Y, Feldpausch TR, Swindles GT, Moss P, McGowan HA, Sim TG, Morris PJ, Benfield A, Courtney-Mustaphi C, Wahl D, Montoya E, Githumbi E, Honorio Coronado EN, Augustijns F, Verstraeten G, Roe JOD, Tibby J, Benavides JC, Hapsari KA, Schittek K, Ramdzan KNM, Bao K, Cole LES, Anderson L, Gałka M, Akpo OE, Strobel P, Bala PR, Dommain R, Marchant R, Sukumar R, Chawchai S, Kavil SP, Mooney S, Kelly TJ, Gao Y, Voulgarakis A, Boom A, Burton C, Berrio JC, Ribeiro K, Anderson LO, Hardiman M, Spater M, Page SE, Gallego-Sala AV.   +45 more
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

The billion-dollar case for sustaining palaeontology's digital databases. [PDF]

Nat Ecol Evol
Dowding EM, Dunne EM, Collins KS, Cryer K, De Baets K, Dimitrijević D, Edie SM, Finnegan S, Kiessling W, Lintulaakso K, Liow LH, Little H, Na L, Peters SE, Renaudie J, Saupe EE, Seuss B, Sessa JA, Smith JA, Uhen MD, Williams JW, Kocsis ÁT.   +21 more
europepmc   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Atmospheric systems drive spatiotemporal divergence of dust and moisture changes across Asia over the past 130,000 years. [PDF]

Sci Adv
Li G, Yang H, Zhang X, Li J, Du P, Han D, Zhou R, Song Y, Fitzsimmons KE, Dave AK, Yi S, Kang S, Stevens T, Buylaert JP, Lai Z, Wang Y, Lai J, Yan Z, Yang J, Wang X, Qin L, Gou S, Chen C, E C, Zhao Q, Wang L, Lu T, Deng Y, Shu L, Yu L, Liu X, Ling Z, Chang Q, Wei H, Xie H, Chen F.   +35 more
europepmc   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Socio-spatial logic of demolition and relocation in urban China. [PDF]

PLoS One
Lin Z, Li G.
europepmc   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source