Results 201 to 210 of about 282,797 (297)

Evaluation of the Medicines and Healthcare products Regulatory Agency's introduction of a risk‐proportionate approach for clinical trials: An analysis of 4617 applications assessed between September 2023 and August 2024

British Journal of Clinical Pharmacology, EarlyView.
Aims The Medicines and Healthcare products Regulatory Agency (MHRA) introduced a risk‐proportionate approach to assess clinical trial applications for authorisation in August 2023. This study evaluates the impact of this approach on the timelines for reviewing proposals.
Andrea Manfrin, Kingyin Lee, Crina Cacou, James Pound, Anthony Harnden, June Raine, Munir Pirmohamed   +6 more
wiley   +1 more source

A new Early Jurassic dinosaur represents the earliest-diverging and oldest sauropodomorph of East Asia. [PDF]

Sci Rep
Wang YM, Zhang QN, Wang YC, Xu H, Chen J, Feng Z, Xu X, Wang T, You HL.   +8 more
europepmc   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Types matter: taxonomic status of <i>Chanodichthys oxycephalus</i> (Bleeker, 1871) (Cypriniformes, Xenocyprididae) and some relevant species of East Asia. [PDF]

Zookeys
Chen X, Su S, Zhang X, Van der Laan R, Zhang E.   +4 more
europepmc   +1 more source

Listening to Hong Kong children's perspectives through pretend play

British Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) has become an increasing concern in recent years. The issue has been regularly discussed by different stakeholders. However, the rising concern regarding quality in ECEC has not seriously taken into account children's perspectives.
Suzannie K. Y. Leung
wiley   +1 more source

A comparison of clinical guidelines, treatment characteristics and outcomes in small cell lung cancer between East Asia and Europe/North America. [PDF]

Front Oncol
Chiang CL, Soo RA, Mok T, Voon PJ, Thamlikitkul L, Cheng Y, Horinouchi H, Cho BC, Xu KL, Ahn MJ.   +9 more
europepmc   +1 more source

Activism as education in and through the youth climate justice movement

British Educational Research Journal, EarlyView.
Abstract Young people worldwide are increasingly participating in a global movement for climate justice, yet to date, little research has examined how youth climate justice activists conceive of and experience activism as education. The present study used in‐depth, semi‐structured interviews with 16 US climate justice activists (aged 15–17) to address ...
Carlie D. Trott
wiley   +1 more source

Contrasting Roles of the Multiple Seas in East Asia on Population Divergence of <i>Smilax sieboldii</i> (Smilacaceae). [PDF]

Ecol Evol
Ru YL, Zhu SS, Fan XY, Li WH, Fu CX, Zhao YP.   +5 more
europepmc   +1 more source

Activism in the arts: Co‐researching cultural inequalities with young people during the COVID‐19 pandemic

British Educational Research Journal, EarlyView.
Abstract This paper explores the growing influence of young people's activism in UK museums and its educational implications. It draws on a five‐year collaborative programme (2019–2023) with young people of colour (16–28) in a university museum setting, focusing on a Young Collective established to address cultural inequalities.
Sadia Habib
wiley   +1 more source

The Historical Biogeography of Divergence in the Relict Cypress <i>Chamaecyparis obtusa</i>, and the Implications for Conservation and Management in East Asia. [PDF]

Ecol Evol
Aihara T, Cheng CH, Chen CP, Wang CT, Uchiyama K, Takahashi D, Suyama Y, Tsumura Y.   +7 more
europepmc   +1 more source