Results 61 to 70 of about 945,060 (308)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, EarlyView.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

Peace, Prosperity and Safety Nets in Timor‐Leste: Competing Priorities or Complementary Investments?

Asia & the Pacific Policy Studies, 2014
Social protection cash transfers are a vital policy instrument in tackling poverty, and provide an affordable, broad‐based foundation for inclusive growth and social stability.
Pamela Dale, Lena Lepuschuetz, Nithin Umapathi   +2 more
doaj   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

Indo-Pacific cooperation: what do trade simulations indicate?

Journal of Economic Structures, 2020
This paper investigates the potential economic effect of ‘Indo-Pacific’ regional economic cooperation and compares with the extended CPTPP. The Computable General Equilibrium (CGE) results show that the quadrilateral alliance between the United States ...
Mohammad Masudur Rahman, Chanwahn Kim, Prabir De   +2 more
doaj   +1 more source

Issues Surrounding The Creation Of A Regional Human Rights System For The Asia-Pacific [PDF]

, 1998
The only major region of the world that does not have a regional human rights commission or court is the Asia-Pacific. The Asia-Pacific can generally be recognized to include not only the entire Asian region, from Japan and the Philippines in the East to
Askin, Kelly Dawn
core   +1 more source

Interface Engineering Suppresses Self‐Annealing in Electroplated Nanograined Copper for Low‐Temperature Copper‐to‐Copper Bonding

Advanced Science, EarlyView.
A (111)‐oriented nanotwinned copper substrate stabilizes the deposited nanograined copper and prevents self‐annealing by restricting grain boundary motion at the interface and promoting the formation of stacking faults within the nanograined copper. Its preserved nanostructure maintains bonding capability even after 30 days of storage, resulting in ...
Gangqiang Peng, Xinyi Dong, Binzhao Li, Chuan He, Cong Chen, Licheng Huang, Jian Liu, Yonghan Zhou, Qikai Li, Hao Gong, Yuechen Wang, Kaiyu Mu, Sheng‐Jye Cherng, Po‐Yen Yang, Yang Lu, Yong Yang, Shih‐Wei Hung, Shien‐Ping Feng   +17 more
wiley   +1 more source

Livestock Tango: U.S. and Latin America Dance Together, but Who Will Lead?

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study examines the competitiveness between Latin American and U.S. livestock and meat sectors. We employ a computable general equilibrium modeling framework to evaluate two scenarios: coordinated improvements in Latin American productivity, transport efficiency, and market access (Scenario I), and the minimum productivity gains required ...
Taís C. Menezes, Amanda M. Countryman, Dustin L. Pendell   +2 more
wiley   +1 more source

Sustainability Strategies in the Cocoa‐Chocolate Value Chain: An Analysis Using Stakeholder Theory, Global Value Chain Theory, and Resource Dependence Theory

Agribusiness, EarlyView.
ABSTRACT The cocoa‐chocolate value chain faces significant environmental and social challenges, driving firms to adopt sustainability strategies ranging from individual practices to third‐party certifications. This study investigates the factors associated with these strategies by analyzing 304 cocoa‐chocolate companies using firm‐level data from the ...
Stella Marschner, Luigi Orsi, Alessandro Olper, Stefanella Stranieri   +3 more
wiley   +1 more source

The Role of Certifications in Improving Household Food Security Among Peruvian Farmers

Agribusiness, EarlyView.
ABSTRACT Achieving global food security requires sustainable transformations in agri‐food systems. Voluntary Sustainability Standards (VSS) such as Organic and Fairtrade aim to internalize certain social and environmental costs while promoting more equitable value distribution, improved market access, and sustainable production practices.
Lisa‐Marie Schulte, Awudu Abdulai
wiley   +1 more source