Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
The development of an online knowledge-based videotheodolite measurement system
Videotheodolite measurement systems have been used in various surveying applications for several years. Unfortunately, most of such systems required artificial targets defining object points. To overcome this restriction the texture on the surface of the
Reiterer, Alexander
core
Noninferential Antiskepticism and the Problem of Easy Knowledge
Abstract How should epistemologists respond to skepticism about knowledge of the external world? Michael Bergmann advocates noninferential antiskepticism. The thought is that, to reply to a skeptical argument, we should start with premises that do not require inference.
openaire +1 more source
T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ±
Sarah J. Wright +10 more
wiley +1 more source
Facts, skills and intuition : A typology of personal knowledge
This paper introduces a knowledge model in which the types of knowledge are formed according to the nature of knowledge. First we use Ryle’s distinction of “that” and “how” knowledge, to which we add further three types. The five knowledge types are then
Baracskai, Zoltán +3 more
core
Building a Generative AI Toolkit for Leveraging Knowledge Processes: The GAIK Project Report [PDF]
While Generative AI (GenAI) has the potential to transform knowledge work, its proper application in business remains a challenge. To obtain benefits from GenAI, companies must navigate a complex landscape of technologies and best practices for their ...
Yangarber, Roman +11 more
core +1 more source
Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs +7 more
wiley +1 more source
How to Formulate Arguments from Easy Knowledge, and Maybe How to Resist Them
Arguments from “easy knowledge” are meant to refute a class of epistemological views, including foundationalism about perceptual knowledge. I present arguments from easy knowledge in their strongest form, and explain why other formulations in the ...
Jackson, Alexander
core
Knowledge management as an important part of strategic management
It can be relatively easy to prove that one of the most important resources of the company is knowledge of employees. The way how we create, store and share the knowledge fre-quently determines the company’s success or failure in the market.
Ivo Formánek
doaj

