Results 91 to 100 of about 764,282 (354)

16p11.2 Locus modulates response to satiety before the onset of obesity [PDF]

, 2015
Background: The 600 kb BP4-BP5 copy number variants (CNVs) at the 16p11.2 locus have been associated with a range of neurodevelopmental conditions including autism spectrum disorders and schizophrenia.
A B Fagundo, A David, A Hilbert, A M Maillard, A Metspalu, A Pain, A Reigo, A Reymond, B Draganski, B Isidor, B Keren, B Rodriguez-Herreros, C Le Caignec, C Mignot, D Dremmel, F Fernandez-Aranda, J S Beckmann, K Männik, L Hippolyte, M B M van den Bree, null null, R Etienne, S J R A Chawner, S Jacquemont, S Jimenez-Murcia, S Kurz, S Martin-Brevet, S Munsch, Z Agüera   +28 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Body dissatisfaction, psychological commitment to exercise and eating behavior in young athletes from aesthetic sports

Revista Brasileira de Cineantropometria e Desempenho Humano, 2013
The prevalence of inadequate eating behavior is high in athletes. However, little is known about the factors that affect this phenomenon in this population.
Maria Elisa Caputo Ferreira, Sebastião Sousa Almeida, Juliana Fernandes Filgueiras, Clara Mockdece Neves, Leonardo de Sousa Fortes   +4 more
doaj   +1 more source

Software Engineering for the Mobile Application Market [PDF]

, 2012
One of the goals of the current United States government is to lower healthcare costs. One of the solutions is to alter the behavior of the population to be more physically active and to eat healthier.
Schwartz, Jacob
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Stress hyper-reactivity increases vulnerability to developing binge-type eating and associated anxiety-like behavior; comparison between Wistar-Kyoto and Sprague-Dawley rats

Frontiers in Nutrition
IntroductionBinge eating disorder (BED) is a widespread eating disorder that primarily affects women worldwide, and it is characterized by the presence of binge eating episodes and the absence of any compensatory behavior to prevent weight gain.
Daniela Sarai Rodríguez-Rangel, Erika Estrada-Camarena, Carolina López-Rubalcava   +2 more
doaj   +1 more source

Gender Differences in Eating Behavior [PDF]

, 2002
University students may encounter personal, family, social, and financial stresses while trying to cope with their academic challenges. Such constraints could affect their eating behavior and health status which, in turn may have negative effects on ...
Cobiac, Lynne, Lin, Khor Geok, Skrzypiec, Grace   +2 more
core  

Body checking in non-clinical women: experimental evidence of a specific impact on fear of uncontrollable weight gain. [PDF]

, 2017
Body checking is used widely among clinical and non-clinical individuals. It is suggested to be a safety behavior, reducing anxiety initially but potentially enhancing eating and shape concerns in the longer term. However, there is little causal evidence
Cooper, Fairburn, Fairburn, Faul, Kraus, Mond, Mountford, Reas, Rosen, Rosen, Shafran, Slade, Tatham, Thompson, Waller, Waller, Waller, Williamson   +17 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source