Results 181 to 190 of about 236,729 (263)
Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing
Advanced Healthcare Materials, EarlyView.Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong +10 morewiley +1 more sourceEngineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction
Advanced Healthcare Materials, EarlyView.FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs, Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu +11 morewiley +1 more sourceHydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging
Advanced Healthcare Materials, EarlyView.Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová +13 morewiley +1 more sourceGenomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes. [PDF]
Nat Ment HealthTermorshuizen JD, Davies HL, Lee SH, Dennis JK, Hübel C, Johnson JS, Lu Y, Munn-Chernoff MA, Peters T, Qi B, Schaumberg KE, Signer RH, Singh K, Ter Kuile AR, Thornton LM, Xu J, Yao S, Yilmaz Z, Zhang R, Zvrskovec J, Abdulkadir M, Ayorech Z, Corfield EC, Havdahl A, Krebs K, Mack TM, Niarchou M, Palviainen T, Sealock JM, Baker JH, Bergen AW, Birgegård A, Boraska Perica V, Bühren K, Burghardt R, Cassina M, Castellini G, Collantoni E, Crowley JJ, Danner UN, Degenhardt F, DeSocio JE, Dina C, Dmitrzak-Węglarz M, Duncan LE, Egberts KM, Foretova L, Giegling I, Gonidakis F, Gordon SD, Grove J, Guillaume S, Guintivano JD, Hartmann AM, Hatzikotoulas K, Herms S, Imgart H, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Karhunen LJ, Kennedy HL, Kiezebrink KM, Kolb T, Larsen JT, Li D, Lilenfeld L, Maj M, Mattingsdal M, Meneguzzo P, Miller AL, Mitchell KS, Monteleone AM, Olsen CM, Padyukov L, Parker R, Pettie MA, Pinto D, Raevuori A, Ripatti S, Roberts ME, Santonastaso P, Savva A, Schmidt UH, Schosser A, Seitz J, Slachtova LL, Slopien A, Sorbi S, Straub PS, Szatkiewicz JP, Tam FI, Tenconi E, Tortorella A, Tsitsika A, van Elburg AA, Wagner G, Watson HJ, Adan RA, Alfredsson L, Andreassen OA, Ask H, Børglum AD, Brandt HA, Collier D, Crawford S, Crow S, Davis LK, de Zwaan M, Dedoussis G, Dick DM, Ehrlich S, Estivill X, Favaro A, Fernández-Aranda F, Fischer K, Forstner AJ, Gorwood P, Hakonarson H, Hebebrand J, Herpertz-Dahlmann B, Hinney A, Hudson JI, Johnson C, Jordan J, Kaplan AS, Kaprio J, Karwautz AF, Kas MJ, Kaye WH, Kennedy JL, Kennedy MA, Keski-Rahkonen A, Kim YR, Klump KL, Landén M, Le Hellard S, Lehto K, Li QS, Lissowska J, Luykx JJ, Maguire SL, Martin NG, Mattheisen M, Medland SE, Mehler P, Micali N, Mitchell JE, Monteleone P, Mortensen PB, Nacmias B, Ophoff RA, Papezova H, Pedersen NL, Petersen LV, Rajcsanyi LS, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripke S, Rujescu D, Rybakowski F, Scherer SW, Slof-Op 't Landt MC, Steiger H, Sullivan PF, Świątkowska B, van Furth EF, Wade TD, Werge T, Whiteman DC, Woodside DB, Wu YK, Zipfel S, Disorders Working Group of the Psychiatric Genomics Consortium, Estonian Biobank (EstBB), Bulik CM, Huckins LM, Breen G, Coleman JRI, Disorders Working Group of the Psychiatric Genomics Consortium. +181 moreeuropepmc +1 more sourcePLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing
Advanced Healthcare Materials, EarlyView.Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu +10 morewiley +1 more sourceAn Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke
Advanced Healthcare Materials, EarlyView.Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li +9 morewiley +1 more source
