Results 51 to 60 of about 423,188 (304)

Weight Stigma, Cognitions, and Disordered Eating [PDF]

, 2017
Weight stigma experiences affect people of all weights and have many negative consequences; despite this, weight stigma is still an acceptable prejudice in our society.
Pelfrey, Sarah E
core   +1 more source

The developmental effects of media-ideal internalization and self-objectification processes on adolescents’ negative body-feelings, dietary restraint, and binge eating [PDF]

, 2014
Despite accumulated experimental evidence of the negative effects of exposure to media-idealized images, the degree to which body image, and eating related disturbances are caused by media portrayals of gendered beauty ideals remains controversial.
A Dakanalis, A Dakanalis, A Dakanalis, A Dakanalis, A Dakanalis, A Dakanalis, A Field, A Must, A Nerini, A Slater, A Slater, AA Haedt-Matt, AB Goldschmidt, AM Kroon Van Diest, Antonios Dakanalis, B Herpertz-Dahlmann, B Moradi, B Moradi, BL Fredrickson, BL Fredrickson, BM Byrne, C Faravelli, C Jacobi, C Matera, C Stefanile, CA Benowitz-Fredericks, CG Fairburn, CG Fairburn, CJ Ferguson, CP Bartlett, D Grange Le, D Neumark-Sztainer, DW Russell, E Mannucci, E Stice, E Stice, E Stice, E Stice, E Stice, E Stice, E Stice, EE Fitzsimmons-Craft, G Lazzeri, G Riva, Giuseppe Carrà, Giuseppe Riva, HA Hausenblas, JK Thompson, JS Aubrey, K Harrison, KA Loth, KC Berg, KJ Preacher, KL Allen, KL Allen, L Conti, L Hu, LR Vartanian, M Tanofsky-Kraff, M Tiggemann, M Tiggemann, Maria Assunta Zanetti, Massimo Clerici, MM Morry, MP Levine, MR Hebl, NM McKinley, NM McKinley, PJ Hay, PK Keel, PK Keel, Rachel Calogero, RJ Kuczmarski, RM Calogero, RM Calogero, RM Calogero, Roberta Fida, S Daniel, S Grabe, S Grabe, SA Swanson, SM Noll, STP Spoor, TA Hart, TD Little, TR Goldstein, WJ Chambers   +86 more
core   +1 more source

The importance of eating behavior in eating disorders [PDF]

Physiology & Behavior, 2010
A disturbance in eating behavior is the defining characteristic of the clinical eating disorders, Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder. Surprisingly little research has been devoted to assessing objectively the nature of the eating disturbances in these disorders, to elucidating what factors contribute to the development and ...
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Body Image and Disordered Eating Among UAF Female Athletes and Non-Athletes [PDF]

, 2012
•Disordered eating and poor body image is a problem in our society for many women •Most eating disorder patients are young females, and female athletes may be particularly at risk •Disordered eating is often associated with perfectionism, poor mental ...
Montgomery, Jordyn
core  

Living in interesting times - Challenging protein metabolism in the era of the epidemiological shift [PDF]

, 2016
The recently released results of the Global Burden of Disease, Injuries, and Risk Factor study 2013 reveal that during the past 23 years, metabolic and behavioral risk factors, including high BMI, increased their impact on global mortality and disability-
Laviano, Alessandro
core   +1 more source

Neuroscience of Compulsive Eating Behavior [PDF]

Frontiers in Neuroscience, 2017
A systematic characterization of compulsivity in pathological forms of eating has been proposed in the context of three functional domains: (1) habitual overeating; (2) overeating to relieve a negative emotional state; and (3) overeating despite aversive consequences.
Catherine F. Moore, Catherine F. Moore, Valentina Sabino, George F. Koob, Pietro Cottone   +4 more
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source