Results 191 to 200 of about 484,622 (308)

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu   +11 more
wiley   +1 more source

Early intervention in eating disorders: introducing the chronopathogram. [PDF]

open access: yesEat Weight Disord
Preti A   +5 more
europepmc   +1 more source

Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

open access: yesAdvanced Science, EarlyView.
A potent HDAC11‐specific inhibitor, B6, is identified using substrate‐mimic and bioisosteric replacement strategies. B6 demonstrates high oral bioavailability, extensive liver distribution, and a favorable safety profile. B6 effectively alleviates metabolic dysfunction‐associated steatotic liver disease by increasing the expression of LKB1 and ...
Feng Zhang   +10 more
wiley   +1 more source

Polycystic Ovary Syndrome and Eating Disorders-A Literature Review. [PDF]

open access: yesJ Clin Med
Góral A   +4 more
europepmc   +1 more source

Symptoms of eating disorders in obsessive‐compulsive disorder [PDF]

open access: bronze, 2000
Hans J. Grabe   +2 more
openalex   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

open access: yesAdvanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu   +19 more
wiley   +1 more source

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