Results 261 to 270 of about 243,728 (328)

Dopant‐Regulated Piezocatalysts Evoke Sonopiezoelectric and Enzymatic PANoptosis for Synergistic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Engineered Mn‐substituted HfO2 (HMO) is identified with enhanced sonopiezoelectric effects and multienzymatic activities, promoting reactive oxygen species generation and amplifying oxidative stress in cancer cells. Upon ultrasound irradiation, HMO evokes cancer cell PANoptosis, thereby triggering robust antitumor immunity.
Linhong Zhong   +9 more
wiley   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

open access: yesAdvanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua   +19 more
wiley   +1 more source

Photonic Bayesian Neural Networks: Leveraging Programmable Noise for Robust and Uncertainty‐Aware Computing

open access: yesAdvanced Science, EarlyView.
This work introduces a novel photonic Bayesian neural network architecture that utilizes tunable photonic random number generators to independently control weight distribution parameters, significantly improving robustness, scalability, and accuracy while demonstrating practical applications in multimodal data processing and uncertainty‐aware computing.
Yangyang Zhuge   +9 more
wiley   +1 more source

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan   +9 more
wiley   +1 more source

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

open access: yesAdvanced Science, EarlyView.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li   +3 more
wiley   +1 more source

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