Results 21 to 30 of about 8,654 (217)

Asset Redeployability and Biodiversity Risk

Business Strategy and the Environment, EarlyView.
ABSTRACT We examine how asset redeployability influences a firm's exposure to biodiversity risk. Our empirical analysis provides robust evidence that firms possessing greater levels of redeployable assets exhibit significantly lower biodiversity risk.
Mostafa Monzur Hasan, Stewart Jones, Md Enayet Hossain   +2 more
wiley   +1 more source

Endogenous endophthalmitis caused by group B streptococcus; case reports and review of 35 reported cases

BMC Ophthalmology, 2020
Background Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE).
Masaaki Yoshida, Shunji Yokokura, Takashi Nishida, Kiyofumi Mochizuki, Takashi Suzuki, Kazuichi Maruyama, Takaaki Otomo, Koji M. Nishiguchi, Hiroshi Kunikata, Toru Nakazawa   +9 more
doaj   +1 more source

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

Clinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout, Aanisah Hanuun, J. G. Coen van Hasselt, Rob C. van Wijk   +3 more
wiley   +1 more source

Integrated Multi-Property Evaluation of Surface Modified Rutile-TiO₂ Nanocomposite Kraft Paper: Moisture-Driven Coupling Effects in Transformer Insulation

IEEE Access
Transformer insulation performance depends on complex interactions among mechanical, electrical, thermal, and moisture-related properties, which are often evaluated independently in conventional studies.
Mohammed K. Mahmood, Cuthbert Nyamupangedengu, Chandima Gomes, Muhammad Salman Minhas   +3 more
doaj   +1 more source

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source

Model‐based clinical pharmacology profiling of subcutaneous nivolumab in renal cell carcinoma: Bridging to alternative dosing regimens and indications

Clinical Pharmacology &Therapeutics, EarlyView.
A novel model‐informed drug development (MIDD) approach was employed to derive the coprimary endpoints (time‐averaged serum concentration over 28 days [Cavgd28] and minimum serum concentration at steady state [Cminss]) of the phase III CheckMate 67T study (NCT04810078).
Yue Zhao, Zheyi Hu, Elizabeth Gibson, Li Zhu, Heather Vezina, Anna G. Kondic   +5 more
wiley   +1 more source

Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan, Lindsey B. Collins, Christopher Staley, Flavia Kiweewa Matovu, Pamala Jacobson, Melanie Nicol, Shen Cheng   +6 more
wiley   +1 more source

Frizyalı Ebe Catharina Schrader’in “Mother and Child Were Saved”Adlı Kitabında Yer Alan Doğum Anılarının İncelenmesi (1693-1740)

Lokman Hekim Dergisi
Amaç: Frizyalı Ebe Catharina Schrader’in “Mother and Child Were Saved”adlı kitabında yer alan doğum deneyimlerine ilişkin anıları ebeliğin tarihsel gelişimi açısından önemli bir kaynaktır.
Ebru Gözüyeşil, Rukiye Sülü Dursun
doaj   +1 more source

Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage

Chinese Medicine, 2011
Background Ericaulon buergerianum (Gujingcao) is an ophthalmic, anti-inflammatory and antimicrobial Chinese medicinal herb. This study aims to investigate the neuroprotective effects of Ericaulon buergerianum ethanol extract (EBE) and to elucidate its ...
Lin Zhixiu, Cheang Lorita, Zhang Zaijun, Wang Meiwei, Lee Simon   +4 more
doaj   +1 more source

Trichoderma strains isolated from Ilex paraguariensis ST. HIL: promising biocontrol agents with chitinolytic activity and plant growth promoter on Lycopersicum esculentum

Arab Journal of Basic and Applied Sciences, 2020
Ilex paraguariensis Saint Hilaire (St. Hil) is an important crop in the north of Argentina, mainly cultivated in the Misiones province. Trichoderma genera are well known for their biological control and plant growth-promoting properties.
Ana Clara López, Adriana Elizabet Alvarenga, Manuela Lizz Vereschuk, Ramona Celeste Barua, Pedro Darío Zapata, María Flavia Luna, Laura Lidia Villaba   +6 more
doaj   +1 more source