Results 71 to 80 of about 8,581 (178)

Simulation‐Based Evaluation of Busulfan Sampling Strategies in Adults and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Busulfan, used in hematopoietic stem cell transplantation, exhibits a narrow therapeutic index and high pharmacokinetic (PK) variability. Therapeutic drug monitoring (TDM) is currently employed to achieve target exposure. However, there is no consensus on an optimal limited sampling strategy (LSS) for busulfan on the once‐daily (QD) regimen. A
Zhiyuan Tan, Federica R. Achini‐Gutzwiller, Arjan C. Lankester, Joost G. K. van der Hem, Peter A. von dem Borne, Dirk Jan. A. R. Moes, Tim Preijers   +6 more
wiley   +1 more source

Adjoint and Unrolled Automatic Differentiation for Laplace‐Approximated Likelihoods in Population PK and PK/PD Models

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Maximum likelihood estimation in population pharmacokinetic/pharmacodynamic (PK/PD) nonlinear mixed‐effects (NLME) models targets fixed‐effect, interindividual‐variability, and residual‐variability parameters through a marginal likelihood that integrates each subject's contribution over individual random effects.
Guido H. Jajamovich, William Holmes, Chih‐Wei Lin, Khamir Mehta   +3 more
wiley   +1 more source

Multimodal Piezotronic‐Gated Ferroelectric Tunneling Junctions for High‐Resolution Tactile Imaging

SmartSys, Volume 2, Issue 3, September 2026.
ABSTRACT Multimodal perception is critical for applications such as virtual reality and human interaction by integrating information to improve the accuracy and reliability of perceiving the external environment. However, conventional single‐mode mechanical sensors frequently encounter the trade‐off between sensitivity and dynamic range, limiting their
Mengmeng Jia, Di Guo, Pengwen Guo, Jiong Pan, Xia Liu, Lele Ren, Mengshuang Chi, Yulong Wang, Shidai Tian, Zhen Yang, Zhong Lin Wang, Junyi Zhai   +11 more
wiley   +1 more source

Integración de la enseñanza de la práctica de enfermería basada en la evidencia científica

Aquichan, 2015
En el 2002, la Facultad de Enfermería de la Pontificia Universidad Católica del Ecuador introdujo la enseñanza de la práctica basada en evidencia científica en el Proyecto de Reforma Curricular y Diversificación de Carreras y una década después se ...
Carmen Falconí Morales, Carmita Jannett Brito Santacruz, Irina Verkovitch   +2 more
doaj   +2 more sources

The Mutable Original: How Chinese Counterfeits Become Nigerian Originals in African Markets

American Anthropologist, Volume 128, Issue 3, Page 581-594, September 2026.
ABSTRACT Affordable Chinese copies of Western brands are ubiquitous in African markets. Despite democratizing consumer access, these goods appear to cement hegemonic value hierarchies that rank Chinese or local products as inferior to Western goods.
Jing Jing Liu
wiley   +1 more source

Erzurum’daki kadınların gebelik sayısına ve aralığına etki eden faktörlerin incelenmesi

Ankara Sağlık Bilimleri Dergisi, 2015
Gebelikler arasındaki süre ve gebelik sayısı hem anne hem de fetal ve neonatal sağlık açısından önemlidir. Türkiye’de en yüksek gebelik oranı ve doğurganlık hızı Doğu Anadolu Bölgesinde görülmektedir.
Serap Ejder Apay, Funda Özdemir, Tuğçe Sakar, Yağmur Özorhan Elif   +3 more
doaj   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses of Savolitinib Alone or in Combination With Osimertinib in Patients With Locally Advanced or Metastatic Solid Tumors

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Savolitinib (ORPATHYS) is an oral, highly selective inhibitor of the mesenchymal–epithelial transition (MET) receptor tyrosine kinase that has demonstrated clinical activity across multiple advanced solid tumors. A comprehensive population pharmacokinetics analysis using cumulative data from 998 patients across 10 clinical studies ...
Azar Shahraz, Thibaud Derippe, Kiran Kumar Kode, Jessica Allmond, Simon Nelson, Ike Igwegbe, Aarti Sawant‐Basak, Karthick Vishwanathan, Kowser Miah   +8 more
wiley   +1 more source

Multispecies Genomics Uncovers a Common Legacy of Postglacial Isolation on a Neotropical Land‐Bridge Island

Journal of Biogeography, Volume 53, Issue 9, September 2026.
ABSTRACT Aim To evaluate whether Pleistocene sea‐level changes can explain the timing and demographic processes of population divergence between continental and insular plant populations on a land‐bridge island. Location Alcatrazes Island and adjacent mainland areas along the southeastern coast of Brazil.
Raphael da Silva, Fábio Pinheiro, Gabriel Pavan Sabino, Tami da Costa Cacossi, Clarisse Palma‐Silva, Marcelo Gehara, Bárbara Simões Santos Leal   +6 more
wiley   +1 more source

Das Buch der Erfindungen Gewerbe und Industrien : Gesamtdarstellung aller Gebiete der gewerblichen und industriellen Arbeit sowie von Weltverkehr und Weltwirtschaft

, 1901
bearbeitet von C. Arndt ; H. W. Dahlen ; G. Ebe [et al.]Bd. 1: VIII, 742 S., 13 Taf. ; Bd. 2: XII, 792 S., 3 Taf. ; Bd. 3: VII, 627 S., 12 Taf. ; Bd. 4: VIII, 758 S., 9 Taf. ; Bd. 5: VIII, 605 S., 12 Taf. ; Bd. 6: VIII, 725 S., 6 Taf. ; Bd.
Arndt, C.
core   +1 more source

Cobalamin‐Dependent O‐Demethylation of Polymethoxyflavones by Enzymes Isolated From the Human Gut Microorganism Blautia producta MRG‐PMF1

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
O‐demethylation of aryl methyl ethers is an invaluable transformation, playing a critical role in ecological circulation by degrading abundant lignin‐derived compounds and other natural products. Chemical O‐demethylation requires harsh reaction conditions; thus, the need for biocatalytic solutions is of high interest.
Niels Krabbe Johnsen, Mykola Franchuk, Freja Elisabeth Wind Rasmussen, Zheng Guo, Jaehong Han, Bekir Engin Eser   +5 more
wiley   +1 more source