Results 31 to 40 of about 3,009 (184)

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

Clinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout, Aanisah Hanuun, J. G. Coen van Hasselt, Rob C. van Wijk   +3 more
wiley   +1 more source

Başarılı emzirmede ebelik faktörleri: Postpartum ilk 6 ay

Journal of Infant, Child and Adolescent Health, 2023
Amaç: Bu çalışma, postpartum ilk 6 aylık süreçte başarılı emzirmenin sağlaması ve sürdürülmesinde ebelik faktörlerinin etkisini araştırmak için yapılmıştır.
Esra Sabancı Baransel, Büşra İkikat, Birgül Ekici, İlknur Oskay   +3 more
doaj  

Ets-1 is essential for connective tissue growth factor (CTGF/CCN2) induction by TGF-β1 in osteoblasts. [PDF]

PLoS ONE, 2012
Ets-1 controls osteoblast differentiation and bone development; however, its downstream mechanism of action in osteoblasts remains largely undetermined. CCN2 acts as an anabolic growth factor to regulate osteoblast differentiation and function.
Max T Geisinger, Randy Astaiza, Tiffany Butler, Steven N Popoff, Sonia Lobo Planey, John A Arnott   +5 more
doaj   +1 more source

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source

Frizyalı Ebe Catharina Schrader’in “Mother and Child Were Saved”Adlı Kitabında Yer Alan Doğum Anılarının İncelenmesi (1693-1740)

Lokman Hekim Dergisi
Amaç: Frizyalı Ebe Catharina Schrader’in “Mother and Child Were Saved”adlı kitabında yer alan doğum deneyimlerine ilişkin anıları ebeliğin tarihsel gelişimi açısından önemli bir kaynaktır.
Ebru Gözüyeşil, Rukiye Sülü Dursun
doaj   +1 more source

Flexible Direct‐Conversion X‐Ray Detectors: From Emerging Materials to Conformal Imaging

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This comprehensive review analyzed the performance, challenges, and future directions of four emerging material systems for next‐generation flexible direct‐conversion X‐ray detectors: organic semiconductors, perovskites, metal–organic frameworks, and inorganic metal compounds.
Haipeng Di, Guoliang Ma, Jiaxin Mu, Kailian Dong, Haibin Li, Manjing Wang, Xin Song, Haojin Li, Jianwei Xu, Yiying Zhao, Jingjing Zhao, Guojia Fang   +11 more
wiley   +1 more source

Examination of Baby Death and Abuse News Published in Newspaper

Florence Nightingale Journal of Nursing, 2019
Aim: The aim of this study was to examine the baby deaths and abuse news published in the newspaper. Methods: A retrospective descriptive study was carried out in January 2015.
Zekiye KARAÇAM, Müge SAĞLIK, Dilek ÖĞÜT   +2 more
doaj  

Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage

Chinese Medicine, 2011
Background Ericaulon buergerianum (Gujingcao) is an ophthalmic, anti-inflammatory and antimicrobial Chinese medicinal herb. This study aims to investigate the neuroprotective effects of Ericaulon buergerianum ethanol extract (EBE) and to elucidate its ...
Lin Zhixiu, Cheang Lorita, Zhang Zaijun, Wang Meiwei, Lee Simon   +4 more
doaj   +1 more source

Verification of False Reactivity in HIV Rapid Diagnostic Tests and Its Translation Into the Three Tests Algorithm in Cameroon

Journal of Clinical Laboratory Analysis, EarlyView.
Verification study enabled the detection of HIV false reactivity ranging from 0‐4% across rapid diagnostic tests. A reliable three‐tests algorithm ranked First Response HIV 1‐2‐0 Card, First Response HIV1+2/Syphilis Combo or STANDARD Q as suitable test 1 to mitigate false positive events. As countries move toward HIV elimination, implementing the three‐
Rogers Ajeh Awoh, Désiré Takou, Isidore Oscar Bienvenu Etogo Ondigui, Roger Onana, Etienne Kembou, Collins Chenwi, Daniel Mabongo, Grace Beloumou Angong, Laetitia Bissai, Aude Christelle Ka'e, Alex Durand Nka, Ezechiel Ngoufack Jagni Semengue, Nadine Fainguem, Daniele Simnoue, Florine Tsimene, Sandrine Djupsa, Jaurès Metambou, Aurelie Kengne, Arlette Messeh, Gilbert Tchatchoua, Naomi‐Karell Etame, Michel Tommo, Krystel Zam Nnomo, Edith Temgoua, Basil Yaba, Gregory Edie Halle Ekane, Carlo‐Federico Perno, Vittorio Colizzi, Nicaise Ndembi, Diaby Ousmane, Joelle Bouba Pamen, Alexis Ndjolo, Celine Lastrucci, Joseph Fokam, Malachie Manouada   +34 more
wiley   +1 more source

Bloodstream-To-Eye Infections Are Facilitated by Outer Blood-Retinal Barrier Dysfunction.

PLoS ONE, 2016
The blood-retinal barrier (BRB) functions to maintain the immune privilege of the eye, which is necessary for normal vision. The outer BRB is formed by tightly-associated retinal pigment epithelial (RPE) cells which limit transport within the retinal ...
Phillip S Coburn, Brandt J Wiskur, Frederick C Miller, Austin L LaGrow, Roger A Astley, Michael H Elliott, Michelle C Callegan   +6 more
doaj   +1 more source