EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA formation [PDF]
Nature CommunicationseccDNA is a driver of many cancers and a potential intermediate in other age-related disorders. However, little is known about the mechanisms underlying eccDNA formation in healthy tissue and how aging affects these processes.
Xue Liang +12 more
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Extrachromosomal circular DNA expressing miRNA promotes ovarian cancer progression [PDF]
Clinical and Translational MedicineBackground Extrachromosomal circular DNA (eccDNA) has emerged as a critical driver of oncogenesis, yet its functional roles in high‐grade serous ovarian cancer (HGSOC) remain poorly characterized. This highlights the need for comprehensive investigations
Ning Wu +9 more
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Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions [PDF]
Scientific Reports, 2023 Chinese hamster ovary (CHO) cell lines are widely used to manufacture biopharmaceuticals. However, CHO cells are not an optimal expression host due to the intrinsic plasticity of the CHO genome.
Dylan G. Chitwood +6 more
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A comprehensive atlas of full-length Arabidopsis eccDNA populations identifies their genomic origins and epigenetic regulation. [PDF]
PLoS BiologyExtrachromosomal circular DNA (eccDNA) has been described in several eukaryotic species and has been shown to impact phenomena as diverse as cancer and herbicide tolerance. EccDNA is thought to arise mainly through transposable element (TE) mobilization.
Syed Shan-E-Ali Zaidi +6 more
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Integrated CIRCLE-seq with RNA-seq to decipher the quantity, localization, and functional features of eccDNA in AML [PDF]
Frontiers in OncologyBackgroundExtrachromosomal circular DNA (eccDNA) plays critical roles in cancer, yet its landscape in acute myeloid leukemia (AML) remains unexplored.MethodsWe used CIRCLE-seq and RNA-seq to characterize eccDNA in 12 AML patients and 4 healthy controls ...
Lijuan Gao +8 more
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Extrachromosomal circular DNAs in the differentiation of human bone marrow mesenchymal stem cells [PDF]
Stem Cell Research & TherapyBackground Extrachromosomal circular DNA (eccDNA) plays a significant role in cancer development. However, our understanding of its role in normal cells is limited.
Yuxi Gu +3 more
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Compartment-specific eccDNA patterns reveal senescence associated biomarkers in hUC-MSCs [PDF]
Scientific ReportsThe therapeutic potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) is significantly constrained by replicative senescence during in vitro expansion.
Qian Yan +8 more
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Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures [PDF]
Cell & BioscienceBackground Extrachromosomal circular DNA (eccDNA) is crucial for carcinogenesis and bile has direct contact with malignant biliary strictures, yet eccDNA features in bile and its function in malignant biliary strictures remain underexplored.
Zhuo Cheng +8 more
doaj +2 more sources
Extrachromosomal circular DNA as a novel biomarker for the progression of colorectal cancer [PDF]
Molecular MedicineBackground Extrachromosomal circular DNA (eccDNA) has potential in tumor diagnosis, particularly for improving diagnostic accuracy and early cancer detection; however, many challenges remain in its application to clinical practice. Methods We conducted a
Quanpeng Qiu +7 more
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Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia [PDF]
Computational and Structural Biotechnology JournalBackground: Extrachromosomal circular DNA (eccDNA) is emerging as a novel biomarker for multiple diseases, but its role in reproductive diseases remains underexplored.
Peng Han +11 more
doaj +2 more sources