EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation
Advanced ScienceGenotoxic therapies such as ionizing radiation eliminate cancer cells by inducing extensive DNA damage but often cause normal tissue toxicity, including cutaneous injury. Extrachromosomal circular DNA (eccDNA) refers to circular DNA fragments outside the
Bin Shi +12 more
semanticscholar +6 more sources
EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA formation [PDF]
Nature CommunicationseccDNA is a driver of many cancers and a potential intermediate in other age-related disorders. However, little is known about the mechanisms underlying eccDNA formation in healthy tissue and how aging affects these processes.
Xue Liang +12 more
semanticscholar +7 more sources
LifeExtrachromosomal circular DNA (eccDNA) is a form of a circular double-stranded DNA that exists independently of conventional chromosomes. eccDNA exhibits a broad and random distribution across eukaryotic cells and has been associated with tumor-related ...
Panagiotis Tsiakanikas +6 more
semanticscholar +6 more sources
Investigating retrotransposon‐derived eccDNA as a source of innate immune activation in tauopathy
Alzheimer's &Dementia, Volume 20, Issue S8, December 2024.Retrotransposon‐derived extrachromosomal circular DNA (eccDNA) was extracted and sequenced from brains with Alzheimer’s disease, progressive supranuclear palsy, or healthy controls.
Morgan Elizabeth Lambert +3 more
semanticscholar +4 more sources
EccDNA, STING activation, and their potential roles in DLBCL prognosis and therapy
Clinical and Translational DiscoveryClinical and Translational Discovery, Volume 4, Issue 5, October 2024.
Xiaomeng Hu +3 more
semanticscholar +5 more sources
EccDNA-oriented ITGB7 expression in breast cancer [PDF]
Annals of Translational Medicine, 2022 Background Extrachromosomal circular DNA (eccDNA) is omnipresent in cancers and related to the progression of tumors and oncogene amplification. However, its function in breast cancer (BC) is unclear.
Lin Yang +9 more
semanticscholar +4 more sources
TeCD: The eccDNA Collection Database for extrachromosomal circular DNA
BMC Genomics, 2023 Background Extrachromosomal circular DNA (eccDNA) is a kind of DNA that widely exists in eukaryotic cells. Studies in recent years have shown that eccDNA is often enriched during tumors and aging, and participates in the development of cell physiological
Jing Guo +4 more
semanticscholar +4 more sources
eccDNA Atlas: a comprehensive resource of eccDNA catalog
Briefings in Bioinformatics, 2023 Extrachromosomal circular DNA (eccDNA) represents a large category of nonmitochondrial and nonplasmid circular extrachromosomal DNA playing an indispensable role in various aspects such as tumorigenesis, immune responses, liquid biopsy, etc.
Tengwei Zhong +5 more
semanticscholar +4 more sources
Extrachromosomal circular DNA (eccDNA): an emerging star in cancer
Biomarker Research, 2022 Extrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists widely in nature and is independent of chromosomes. EccDNA has attracted the attention of researchers due to its broad, random distribution, complex biogenesis and ...
Ruomeng Li +3 more
semanticscholar +4 more sources
ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data [PDF]
BMC Bioinformatics, 2022 Extrachromosomal circular DNAs (eccDNAs) are ring-like DNA structures physically separated from the chromosomes with 100 bp to several megabasepairs in size.
Ludwig Mann +3 more
semanticscholar +8 more sources