Results 91 to 100 of about 1,406 (212)
Microsatellite Induced Genomic Instability and Mutagenesis Through Break Induced Replication [PDF]
, 2023 Faithful DNA replication is essential to maintain genomic integrity. Compromises in this process are among the prime causes of cancer and other genetic disorders.
Gadgil, Rujuta Yashodhan
core +1 more source
Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance
Clinical and Experimental MedicineAbstractExtrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a close relationship with cancer, which has attracted widespread attention from researchers.
Li, Zhaoxing, Qian, Daohai
openaire +2 more sources
iLABMED, Volume 3, Issue 3, Page 246-257, September 2025.Extrachromosomal circular DNA (eccDNA) has quite recently turned out to be a cardinal component in cardiovascular diseases (CVD), governing the gene expression and mechanisms of disease causation. Studies indicated an upregulation of eccDNA in pulmonary arterial hypertension (PAH), which makes it strikingly potential as a sensitive and specific ...
Saim Mahmood Khan +6 more
wiley +1 more source
Nature Communications, 2023 Abundant extrachromosomal circular DNA (eccDNA) is associated with transposable element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic regulations and what is its impact on the genome is understudied.
Panpan Zhang +9 more
doaj +1 more source
Exosomes in Metabolic Diseases: From Molecular Mechanisms to Clinical Applications
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.We summarize recent progress in exosome biology and elucidate their roles in interorgan communication networks underlying metabolic pathogenesis. We also comprehensively examine the evolving application of exosomes in metabolic disease management, with a focus on critically evaluating preclinical and clinical advances in exosome‐mediated therapeutic ...
Yanting Wu +3 more
wiley +1 more source
Palmer amaranth's arsenal: Rearrangement of eccDNA provides dual herbicide resistance in Amaranthus palmeri. [PDF]
Plant CellHung YH.
europepmc +3 more sources
The role of mobile DNA elements in the dynamics of plant genome plasticity. [PDF]
J Exp BotPlants host a range of DNA elements capable of self-replication. These molecules, usually associated to the activity of transposable elements or viruses, are found integrated in the genome or in the form of extrachromosomal DNA.
Emmerson R, Catoni M.
europepmc +3 more sources
Characterization of extrachromosomal circular DNA (eccDNA) structure, function, and dynamics in a CHO K-1 clone [PDF]
, 2023 Please click Additional Files below to see the full ...
Chitwood, Dylan +6 more
core +1 more source
Advanced Science, Volume 12, Issue 25, July 3, 2025.Extrachromosomal Circular DNA In article number 2501934, Bin Shi, Shuyu Zhang, and co‐workers present the increased existence of eccDNA induced by ionizing radiation. VPS41 gene in the eccDNA confers protection against genotoxic stress. This study highlights the role of eccDNA in cellular defense, providing strategies to enhance tissue resilience to ...
Bin Shi +12 more
wiley +1 more source