Results 91 to 100 of about 1,090 (186)

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 6, June 2025.
ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Jiajia Li, Peng Luo, Zhengrui Li, Qi Wang, Xufeng Huang, Keliang Wang, Ruo Wang, Runzhi Chen   +7 more
wiley   +1 more source

Deciphering extrachromosomal circular DNA in Arabidopsis

Computational and Structural Biotechnology Journal, 2021
Extrachromosomal circular DNA (eccDNA) is independent of the chromosome and exists in many eukaryotes. However, the nature and origin of eccDNA in plants remains unclear.
Keyi Wang, Hui Tian, Lequn Wang, Lin Wang, Yacong Tan, Ziting Zhang, Kai Sun, Meng Yin, Qinggong Wei, Baohua Guo, Jinyu Han, Peiru Zhang, Han Li, Yulong Liu, Hongwei Zhao, Xiaoyong Sun   +15 more
doaj  

Amplification of a Zygosaccharomyces bailii DNA Segment in Wine Yeast Genomes by Extrachromosomal Circular DNA Formation [PDF]

, 2011
We recently described the presence of large chromosomal segments resulting from independent horizontal gene transfer (HGT) events in the genome of Saccharomyces cerevisiae strains, mostly of wine origin.
A Toh-e, A Toh-e, AC Frank, AR Borneman, B Dujon, B Dujon, C Bidenne, C Damon, C Hall, C Sacerdot, CS Hoffman, D Gresham, D Hourcade, DA Fitzpatrick, DE Libuda, DR Zerbino, Emmanuelle Beyne, F Kuttler, F Paques, F Tajima, Frédéric Bigey, G Liti, G Liti, H Araki, H Horowitz, I Utatsu, IK Moore, J Schacherer, JC Fay, JE Hill, Jean-Luc Legras, JK Moore, JL Argueso, JL Campbell, JL Legras, JL Ma, JM Daley, JR Broach, JV Van Houten, K Tamura, LA Kavanaugh, LA Muller, M Marcet-Houben, M McVey, M Novo, M Ricchetti, Maite Novo, N Saitou, N van Loon, Nikolas Nikolaidis, PJ Keeling, PJ Keeling, R Koszul, RC Edgar, S Kurtz, Serge Casaregola, SF Altschul, SW Doniger, Sylvie Dequin, T Rolland, TA Richards, TR Hughes, U Guldener, V Galeote, V Wood, Virginie Galeote, W Wei, X Yu, Z Cohen   +68 more
core   +2 more sources

The EccDNA Replicon: A Heritable, Extranuclear Vehicle That Enables Gene Amplification and Glyphosate Resistance in Amaranthus palmeri[OPEN]

The Plant Cell, 2020
The eccDNA replicon is a large extranuclear circular DNA that is composed of a sophisticated repetitive structure and harbors the EPSPS and several other genes that are transcribed during glyphosate stress.
W. Molin, Allison Yaguchi, M. Blenner, C. Saski   +3 more
semanticscholar   +1 more source

Chromosome‐level assemblies of Amaranthus palmeri, Amaranthus retroflexus, and Amaranthus hybridus allow for genomic comparisons and identification of a sex‐determining region

The Plant Journal, Volume 121, Issue 4, February 2025.
Significance Statement We generated high‐quality genome assemblies for three economically important weeds in the Amaranthus genus. From these, we identified the sex‐determining region in a dioecious species and described important contributors to herbicide resistance in these species: cytochrome P450 gene families and extrachromosomal DNA carrying the ...
Damilola A. Raiyemo, Jacob S. Montgomery, Luan Cutti, Fatemeh Abdollahi, Victor Llaca, Kevin Fengler, Alexander J. Lopez, Sarah Morran, Christopher A. Saski, David R. Nelson, Eric L. Patterson, Todd A. Gaines, Patrick J. Tranel   +12 more
wiley   +1 more source

Characterization of radiations‐induced genomic structural variations in Arabidopsis thaliana

The Plant Journal, Volume 121, Issue 1, January 2025.
Significance Statement Exposure to genotoxic stress activates DNA damage response (DDR) and challenges genome integrity. Using third generation sequencing technology, we characterized alterations of the linear genome structure of Arabidopsis plants treated with non‐ionizing (UV‐B, UV‐C) and ionizing radiations (protons). We identified, in wild type and
Salimata Ousmane Sall, Abdelmalek Alioua, Sébastien Staerck, Stéfanie Graindorge, Michel Pellicioli, Jacky Schuler, Catherine Galindo, Quentin Raffy, Marc Rousseau, Jean Molinier   +9 more
wiley   +1 more source

Targeted removal of mitochondrial DNA from mouse and human extrachromosomal circular DNA with CRISPR-Cas9

Computational and Structural Biotechnology Journal, 2022
Extrachromosomal circular DNA (eccDNA) of chromosomal origin is common in eukaryotic cells. Amplification of oncogenes on large eccDNA (ecDNA) can drive biological processes such as tumorigenesis, and identification of eccDNA by sequencing after removal ...
Weijia Feng, Gerard Arrey, Egija Zole, Wei lv, Xue Liang, Peng Han, Marghoob Mohiyuddin, Henriette Pilegaard, Birgitte Regenberg   +8 more
doaj  

Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy

Cell Death and Disease, 2022
Cisplatin (DDP) resistance is an important factor that decreases the effect of chemotherapy, thus leading to local recurrence and lymph node metastasis of hypopharyngeal squamous cell carcinoma (HSCC).
Changwei Lin, Yifei Chen, Fan Zhang, Baiying Liu, Canbin Xie, Yexun Song   +5 more
doaj   +1 more source

First report of glyphosate resistance in an Amaranthus palmeri population from Europe

Weed Research, Volume 65, Issue 1, January/February 2025.
Abstract The invasive weed Amaranthus palmeri is spreading throughout Spain, with Catalonia being one of the most affected regions. For this species, acetolactate synthase‐inhibiting herbicide‐resistant populations have been reported, and now glyphosate resistance is also suspected.
Alfredo Manicardi, Andrea Milani, Laura Scarabel, Germán Mora, Jordi Recasens, Josep María Llenes, José María Montull, Joel Torra   +7 more
wiley   +1 more source

Categorizing Extrachromosomal Circular DNA as Biomarkers in Serum of Cancer

Biomolecules
Extrachromosomal circular DNA (eccDNA), a double-stranded circular DNA molecule found in multiple organisms, has garnered an increasing amount of attention in recent years due to its close association with the initiation, malignant progression, and ...
Enze Deng, Xiaoying Fan
doaj   +1 more source