Results 171 to 180 of about 1,090 (186)

FLED: a full-length eccDNA detector for long-reads sequencing data

Briefings in Bioinformatics, 2023
Reconstructing the full-length sequence of extrachromosomal circular DNA (eccDNA) from short sequencing reads has proved challenging given the similarity of eccDNAs and their corresponding linear DNAs.
Fuyu Li, Wenlong Ming, Wenxiang Lu, Ying Wang, Xiaohan Li, Xianjun Dong, Yunfei Bai   +6 more
semanticscholar   +3 more sources

EccDNA in plant-stress and biotechnological solutions in agriculture.

Trends in Biotechnology
Extrachromosomal circular DNA (eccDNA) is genetic material that exists outside of chromosomes and holds potential for next-generation genetic engineering in plant biology. By improving plant resilience, growth, and productivity, eccDNA offers a promising solution to global challenges in food security and environmental sustainability, making this a ...
Binoop Mohan, Doni Thingujam, Karolina M. Pajerowska-Mukhtar, M. S. Mukhtar   +3 more
semanticscholar   +3 more sources

Short human eccDNAs are predictable from sequences

Briefings in Bioinformatics, 2023
Abstract Background Ubiquitous presence of short extrachromosomal circular DNAs (eccDNAs) in eukaryotic cells has perplexed generations of biologists. Their widespread origins in the genome lacking apparent specificity led some studies to conclude their formation as random or near-random. Despite this,
Kai-Li, Chang, Jia-Hong, Chen, Tzu-Chieh, Lin, Jun-Yi, Leu, Cheng-Fu, Kao, Jin Yung, Wong, Huai-Kuang, Tsai   +6 more
openaire   +2 more sources

S1993 Elucidating the Oncogenic Roles of Extrachromosomal Circular DNA (eccDNA) in Hepatitis B Virus-Associated Liver Cirrhosis and Hepatocellular Carcinoma: Implications for Early Diagnostic Markers

American Journal of Gastroenterology
Conclusion: Linkage to care through telephone or email was grossly unsuccessful in this urban, low socioeconomic community. There was a steep drop in participation along each chain link: patient identi fi cation, initialcontact, willingnesstoschedule ...
Wenjun Pu, D. Tang, Yong Dai
semanticscholar   +1 more source

Breast Cancer eccDNA functional analysis

2022
Extrachromosomal circular DNAs (eccDNAs) are circular and mobile DNA molecules derived from linear chromosomes. They have been found in various tumor types. However, the genomic characterization and the potential role of eccDNAs in the carcinogenesis of breast cancer remain unknown.
openaire   +1 more source

The Function and Production of eccDNA

2020
The hallmark of oncogenesis is genetic alterations that lead to unregulated cell proliferation and migration. One type of genetic alteration is the excision or copying of DNA from the chromosome body during DNA repair followed by ligation of the non-chromosomal DNA to form extrachromosomal circular DNA (eccDNA).
openaire   +1 more source

A three-stage eccDNA based molecular profiling significantly improves the identification, prognosis assessment and recurrence prediction accuracy in patients with glioma.

Cancer Letters, 2023
Zesheng Li, Bo Wang, Hao Liang, Ying Li, Zhen-yu Zhang, Lei Han   +5 more
semanticscholar   +1 more source

eccDNAMamba: A Pre-Trained Model for Ultra-Long eccDNA Sequence Analysis

arXiv.org
Extrachromosomal circular DNA (eccDNA) plays key regulatory roles and contributes to oncogene overexpression in cancer through high-copy amplification and long-range interactions. Despite advances in modeling, no pre-trained models currently support full-
Zhenke Liu, Jien Li, Ziqi Zhang
semanticscholar   +1 more source

P0036 NRG1, a gene significantly detected from intestinal mucosa eccDNA, may predict therapeutic response in Inflammatory Bowel Disease

Journal of Crohn's & Colitis
Many patients with Inflammatory Bowel Diseases do not respond to biological therapies. Extrachromosomal circular DNA(eccDNA) has been showed to play a role in the pathophysiology of IBD, as there is a higher presence of eccDNA in the intestinal ...
V. Emoli, E. Foscarini, F. Di Vincenzo, L. Masi, S. Troisi, C. Pane, G. Migliore, A. Piazzesi, L. Turchini, D. Pugliese, L. Laterza, L. Lopetuso, A. Papa, G. Cammarota, L. Putignani, A. Gasbarrini, F. Scaldaferri, V. Petito   +17 more
semanticscholar   +1 more source

P0032 Human Extrachromosomal Circular DNA (EccDNA) is a Novel Biomarker in Inflammatory Bowel Disease

Journal of Crohn's & Colitis
Inflammatory Bowel Diseases (IBD), comprising Ulcerative Colitis (UC) and Crohn’s Disease (CD), are chronic, relapsing-remitting disorders of the gastrointestinal tract with unclear etiology.
F. Di Vincenzo, V. Petito, D. Gerovska, A. Piazzesi, A. Russo, L. Turchini, L. Masi, L. Lopetuso, B. Regenberg, A. Gasbarrini, L. Putignani, M. J. Aruzo-Bravo, F. Scaldaferri   +12 more
semanticscholar   +1 more source