Extrachromosomal circular DNA (eccDNA) characteristics in the bile and plasma of advanced perihilar cholangiocarcinoma patients and the construction of an eccDNA-related gene prognosis model [PDF]
Frontiers in Cell and Developmental BiologyExtrachromosomal DNAs (eccDNAs) frequently carry amplified oncogenes. This investigation aimed to examine the occurrence and role of eccDNAs in individuals diagnosed with advanced perihilar cholangiocarcinoma (pCCA) who exhibited distinct prognostic ...
Shijie Fu +8 more
semanticscholar +8 more sources
eccDB: a comprehensive repository for eccDNA-mediated chromatin contacts in multi-species [PDF]
Bioinformatics, 2022 The role of extrachromosomal circular DNA (eccDNA) has been highlighted. More recently, eccDNA-chromosome interactions were identified, suggesting a potential role of eccDNA in transcriptional regulation.
Min Yang +10 more
semanticscholar +4 more sources
Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance
Clinical and Experimental MedicineExtrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a close relationship with cancer, which has ...
Zhaoxing Li, Daohai Qian
semanticscholar +4 more sources
Food Science &Nutrition, Volume 13, Issue 5, May 2025.We provide a new and basic eccDNA database for the molecular regulation of muscle firmness in grass carp. The eccDNA abundance in crisp grass carp was significantly higher than that in ordinary grass carp. EccDNAs likely play important roles in the muscle‐hardening of crisp grass carp.
Kai Zhang +8 more
wiley +4 more sources
CircleBase: an integrated resource and analysis platform for human eccDNAs [PDF]
Nucleic Acids Research, 2021 AbstractRapid advances in high-throughput sequencing technologies have led to the discovery of thousands of extrachromosomal circular DNAs (eccDNAs) in the human genome. Loss-of-function experiments are difficult to conduct on circular and linear chromosomes, as they usually overlap.
Xiaolu Zhao +9 more
openalex +3 more sources
Extrachromosomal Circular DNA (eccDNA): From Chaos to Function [PDF]
Frontiers in Cell and Developmental Biology, 2022 Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and origin and has been identified in both normal and cancer cells.
Shanru Zuo +8 more
semanticscholar +4 more sources
EpigeneticsTo explore SLE staging markers, we analyzed eccDNA in plasma using circular sequencing, comparing healthy controls (HC), active SLE (ASLE), and inactive SLE (ISLE) patients.
Yali Peng +9 more
semanticscholar +5 more sources
Technical and biological variations in the purification of extrachromosomal circular DNA (eccDNA) and the finding of more eccDNA in the plasma of lung adenocarcinoma patients compared with healthy donors [PDF]
bioRxivAbstractHuman plasma DNA originates from all tissues and organs, holding the potential as a versatile marker for diseases such as cancer, as fragments of cancer-specific alleles can be found circulating in the blood. While linear DNA has been studied intensely as a liquid biomarker, the role of circular circulating DNA in cancer is more unknown due, in
Egija Zole +8 more
semanticscholar +3 more sources
Detecting Full-Length EccDNA with FLED and long-reads sequencing [PDF]
bioRxiv, 2023 Reconstructing the full-length sequence of extrachromosomal circular DNA (eccDNA) from short sequencing reads has proved challenging given the similarity of eccDNAs and their corresponding linear DNAs.
Fu‐Yu Li +6 more
openalex +2 more sources
HyenaCircle: a HyenaDNA-based pretrained large language model for long eccDNA prediction
Frontiers in GeneticsIntroduction Extrachromosomal circular DNA (eccDNA) represents a class of circular DNA molecules derived from chromosomes with diverse roles in disease.
Fuyu Li, Wenxiang Lu, Yunfei Bai
semanticscholar +4 more sources