EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation [PDF]
Advanced ScienceGenotoxic therapies such as ionizing radiation eliminate cancer cells by inducing extensive DNA damage but often cause normal tissue toxicity, including cutaneous injury. Extrachromosomal circular DNA (eccDNA) refers to circular DNA fragments outside the
Bin Shi +12 more
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Effects of nucleases on cell-free extrachromosomal circular DNA [PDF]
JCI Insight, 2022 Cell-free extrachromosomal circular DNA (eccDNA) as a distinct topological form from linear DNA has recently gained increasing research interest, with possible clinical applications as a class of biomarkers.
Sarah T.K. Sin +15 more
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TeCD: The eccDNA Collection Database for extrachromosomal circular DNA
BMC Genomics, 2023 Background Extrachromosomal circular DNA (eccDNA) is a kind of DNA that widely exists in eukaryotic cells. Studies in recent years have shown that eccDNA is often enriched during tumors and aging, and participates in the development of cell physiological
Jing Guo +4 more
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scEccDNAdb: an integrated single-cell eccDNA resource for human and mouse. [PDF]
Database (Oxford)Abstract Extrachromosomal circular DNA (eccDNA), an extrachromosomal circular structured DNA, is extensively found in eukaryotes. Investigating eccDNA at the single-cell level is crucial for understanding cellular heterogeneity, evolution, development, and specific cellular functions.
Wang W +5 more
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Investigating cellular heterogeneity at the single-cell level by the flexible and mobile extrachromosomal circular DNA [PDF]
Computational and Structural Biotechnology Journal, 2023 Extrachromosomal circular DNA (eccDNA) is a special class of DNA derived from linear chromosomes. It coexists independently with linear chromosomes in the nucleus.
Jiajinlong Kang +4 more
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Extrachromosomal circular DNA (eccDNA): an emerging star in cancer
Biomarker Research, 2022 Extrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists widely in nature and is independent of chromosomes. EccDNA has attracted the attention of researchers due to its broad, random distribution, complex biogenesis and ...
Ruomeng Li +3 more
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ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data [PDF]
BMC Bioinformatics, 2021 Backround: Extrachromosomal circular DNAs (eccDNAs) are ring-like DNA structures physically separated from the chromosomes with 100 bp to several megabasepairs in size.
Heitkam, Tony +3 more
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Replication independent formation of extrachromosomal circular DNA in mammalian cell-free system. [PDF]
PLoS ONE, 2009 Extrachromosomal circular DNA (eccDNA) is a pool of circular double stranded DNA molecules found in all eukaryotic cells and composed of repeated chromosomal sequences. It was proposed to be involved in genomic instability, aging and alternative telomere
Zoya Cohen, Sara Lavi
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Identification and characterization of eccDNA-driven genes in humans [PDF]
PLoS OneExtrachromosomal circular DNA (eccDNA) amplification promotes oncogene expression and cancer development. However, the global transcriptional landscape mediated by eccDNA has not yet been extensively profiled. Here we report a comprehensive analysis spanning cancer, non-cancerous disease and health by developing a new approach to catalog eccDNA-driven ...
Gu Y, Song Y, Liu J.
europepmc +4 more sources
Extracellular DNA secreted in yeast cultures is metabolism-specific and inhibits cell proliferation [PDF]
Microbial Cell, 2023 Extracellular DNA (exDNA) can be actively released by living cells and different putative functions have been attributed to it. Further, homologous exDNA has been reported to exert species-specific inhibitory effects on several organisms.
Elisabetta de Alteriis +19 more
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