Results 191 to 200 of about 1,406 (212)

Circle-seq reveals that eccDNA may be a key blood biomarker for HBV-associated liver cancer. [PDF]

Front Genet
Ran XK, Zhao XF, Wei ZW, Pang HZ, Tang YF, Liu R, Wu TX, Liu XD.   +7 more
europepmc   +1 more source

Biological processes of eccDNA-driven drivers.

Yuxi Gu (11386081), Yidan Song (4451473), Jun Liu (42548)   +2 more
openalex   +1 more source

Impaired DNA methylation shifts eccDNA profile.

Syed Shan-e-Ali Zaidi (2805160), Sara Shakir (2559325), Hanne De Kort (3248907), Devang Mehta (4227280), Vu Nguyen (320324), Ruben Gutzat (21722251), Hervé Vanderschuren (3294039)   +6 more
openalex   +1 more source

Chromosome-level assemblies of Amaranthus palmeri, Amaranthus retroflexus, and Amaranthus hybridus allow for genomic comparisons and identification of a sex-determining region. [PDF]

Plant J
Raiyemo DA, Montgomery JS, Cutti L, Abdollahi F, Llaca V, Fengler K, Lopez AJ, Morran S, Saski CA, Nelson DR, Patterson EL, Gaines TA, Tranel PJ.   +12 more
europepmc   +1 more source

Intratumoral heterogeneity and drug resistance in cancer. [PDF]

Cancer Cell Int
Fu YC, Liang SB, Luo M, Wang XP.
europepmc   +1 more source

eccDNA characterization and the number of full-length TEs in eccDNAs.

Syed Shan-e-Ali Zaidi (2805160), Sara Shakir (2559325), Hanne De Kort (3248907), Devang Mehta (4227280), Vu Nguyen (320324), Ruben Gutzat (21722251), Hervé Vanderschuren (3294039)   +6 more
openalex   +1 more source

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Short human eccDNAs are predictable from sequences

Briefings in Bioinformatics, 2023
Abstract Background Ubiquitous presence of short extrachromosomal circular DNAs (eccDNAs) in eukaryotic cells has perplexed generations of biologists. Their widespread origins in the genome lacking apparent specificity led some studies to conclude their formation as random or near-random. Despite this,
Kai-Li, Chang, Jia-Hong, Chen, Tzu-Chieh, Lin, Jun-Yi, Leu, Cheng-Fu, Kao, Jin Yung, Wong, Huai-Kuang, Tsai   +6 more
openaire   +2 more sources

Purification, full-length sequencing and genomic origin mapping of eccDNA

Nature Protocols, 2022
Extrachromosomal circular DNA (eccDNA) was discovered more than half a century ago. However, its biogenesis and function have just begun to be elucidated. One hurdle that has prevented our understanding of eccDNA is the difficulty in obtaining pure eccDNA from cells.
Yuangao Wang, Meng Wang, Yi Zhang
openaire   +2 more sources

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis

Nature, 2023
Retrotransposons are highly enriched in the animal genome1-3. The activation of retrotransposons can rewrite host DNA information and fundamentally impact host biology1-3. Although developmental activation of retrotransposons can offer benefits for the host, such as against virus infection, uncontrolled activation promotes disease or potentially drives
Fu Yang, Weijia Su, Oliver W. Chung, Lauren Tracy, Lu Wang, Dale A. Ramsden, ZZ Zhao Zhang   +6 more
openaire   +2 more sources

Breast Cancer eccDNA functional analysis

2022
Extrachromosomal circular DNAs (eccDNAs) are circular and mobile DNA molecules derived from linear chromosomes. They have been found in various tumor types. However, the genomic characterization and the potential role of eccDNAs in the carcinogenesis of breast cancer remain unknown.
openaire   +1 more source