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eccDNA purification, full-length sequencing, and genomic mapping
2022AbstractExtrachromosomal circular DNA (eccDNA) has been discovered for more than half a century1. However, its biogenesis and function have just begun to be elucidated. One hurdle that prevented our understanding of eccDNA is the difficulty in obtaining pure eccDNA from cells. The current eccDNA purification methods mainly rely on exonuclease digestion
Yuangao Wang, Meng Wang, Yi Zhang
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Bioinformatics advances in eccDNA identification and analysis
OncogeneExtrachromosomal circular DNAs (eccDNAs) are a unique class of chromosome-originating circular DNA molecules, which are closely linked to oncogene amplification. Due to recent technological advances, particularly in high-throughput sequencing technology, bioinformatics methods based on sequencing data have become primary approaches for eccDNA ...
Fuyu Li +5 more
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The Function and Production of eccDNA
2020The hallmark of oncogenesis is genetic alterations that lead to unregulated cell proliferation and migration. One type of genetic alteration is the excision or copying of DNA from the chromosome body during DNA repair followed by ligation of the non-chromosomal DNA to form extrachromosomal circular DNA (eccDNA).
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EccDNA in plant-stress and biotechnological solutions in agriculture
Trends in BiotechnologyExtrachromosomal circular DNA (eccDNA) is genetic material that exists outside of chromosomes and holds potential for next-generation genetic engineering in plant biology. By improving plant resilience, growth, and productivity, eccDNA offers a promising solution to global challenges in food security and environmental sustainability, making this a ...
Binoop, Mohan +3 more
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Detecting Full-Length EccDNA with FLED and long-reads sequencing
2023AbstractReconstructing the full-length sequence of extrachromosomal circular DNA (eccDNA) from short sequencing reads has proved challenging given the similarity of eccDNAs and their corresponding linear DNAs. Previous sequencing methods were unable to achieve high-throughput detection of full-length eccDNAs.
Fuyu Li +6 more
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Characteristics of eccDNAs in IgA nephropathy
IgAN is the most common primary glomerulonephritis, however a more thorough understanding of the immune process and an applicable noninvasive diagnostic method are still needed. Extrachromosomal circular DNA (eccDNA) involved in multiple biological processes and may act as a biomarker.openaire +1 more source
eccDNA Atlas Reveals Features that Protect Genes from Transcription-Induced eccDNA Formation
2023Gerard Arrey +12 more
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Characterizing Gene Amplifications in Extrachromosomal Circular DNA (eccDNA) of Colon Cancer
Extrachromosomal circular DNA (eccDNA) exists outside the linear chromosomes and, while present in normal cells, takes on a more critical role in cancer [1]. It can harbor oncogenes and regulatory elements that drive tumorigenesis. In the case of colon cancer, which is the third most common cancer worldwide [2], eccDNA may be especially impactful.Mufeed, Talha +2 more
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The eccDNA and transcriptome in alcoholic liver cirrhosis
We conducted a study to investigate the presence of extrachromosomal circular DNA (eccDNA) in livers with alcoholic cirrhosis (ALC) compared to healthy controls. We utilized Circle-Seq and Bulk-Seq techniques to identify differences in eccDNA profiles and gene expression patterns in liver samples obtained from three ALC patients and three healthy ...openaire +1 more source
FUNCTIONAL IMPLICATIONS OF EXTRACHROMOSMAL CIRCULAR DNA (eccDNA) IN THE MALE GERMLINE
Fertility and Sterility, 2023Melanie Evans +5 more
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