Association analysis of A20 eccDNA mRNA in B-cell lymphoma cells and its application in the study of platinum nanoenzyme therapy mechanism [PDF]
BIO Web of ConferencesDiffuse large B-cell lymphoma (DLBCL) is a common but difficult to treat type of non Hodgkin lymphoma. At present, platinum nanoparticles with enzyme mimicking activity - platinum nanoenzymes - have been well applied in the treatment of DLBCL disease ...
Lei Zhao +5 more
semanticscholar +4 more sources
Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis
Nature, 2023 Retrotransposons are highly enriched in the animal genome1-3. The activation of retrotransposons can rewrite host DNA information and fundamentally impact host biology1-3. Although developmental activation of retrotransposons can offer benefits for the host, such as against virus infection, uncontrolled activation promotes disease or potentially drives
Fu Yang +6 more
semanticscholar +3 more sources
ecGBMsub: an integrative stacking ensemble model framework based on eccDNA molecular profiling for improving IDH wild-type glioblastoma molecular subtype classification [PDF]
Frontiers in PharmacologyIDH wild-type glioblastoma (GBM) intrinsic subtypes have been linked to different molecular landscapes and outcomes. Accurate prediction of molecular subtypes of GBM is very important to guide clinical diagnosis and treatment. Leveraging machine learning
Ze‐Sheng Li +3 more
openalex +2 more sources
Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer [PDF]
Molecular Cancer, 2021 Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from but are likely independent of chromosomes. Due to technological advancements, eccDNAs have recently emerged as multifunctional molecules with numerous ...
X. Ling +8 more
semanticscholar +5 more sources
PLCG2 can exist in eccDNA and contribute to the metastasis of non-small cell lung cancer by regulating mitochondrial respiration [PDF]
Cell Death and Disease, 2023 Extrachromosomal circular DNAs (eccDNAs) participate in tumorigenesis and tumor progression. However, the role and mechanism of eccDNAs have yet to be elucidated in non-small cell lung cancer (NSCLC).
Yongfeng Yang +7 more
openalex +2 more sources
Scientific Reports, 2023 Chinese hamster ovary (CHO) cell lines are widely used to manufacture biopharmaceuticals. However, CHO cells are not an optimal expression host due to the intrinsic plasticity of the CHO genome.
Dylan G. Chitwood +6 more
semanticscholar +2 more sources
Effects of nucleases on cell-free extrachromosomal circular DNA [PDF]
JCI Insight, 2022 Cell-free extrachromosomal circular DNA (eccDNA) as a distinct topological form from linear DNA has recently gained increasing research interest, with possible clinical applications as a class of biomarkers.
Sarah T.K. Sin +15 more
doaj +2 more sources
Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Zijuan Wu +14 more
wiley +4 more sources
Data from Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation [PDF]
Molecular Cancer Research, 2023 Abstract Cell-free circulating linear DNA is being explored for noninvasive diagnosis and management of tumors and fetuses, the so-called liquid biopsy. Previously, we observed the presence of small extrachromosomal circular DNA (eccDNA), called microDNA, in the nuclei of mammalian tissues and cell lines.
Pankaj Kumar +5 more
+5 more sources