Extrachromosomal circles of satellite repeats and 5S ribosomal DNA in human cells [PDF]
Mobile DNA, 2010 Background Extrachomosomal circular DNA (eccDNA) is ubiquitous in eukaryotic organisms and was detected in every organism tested, including in humans. A two-dimensional gel electrophoresis facilitates the detection of eccDNA in preparations of genomic ...
Cohen Sarit +3 more
doaj +4 more sources
Extrachromosomal circular DNA (eccDNA) characteristics in the bile and plasma of advanced perihilar cholangiocarcinoma patients and the construction of an eccDNA-related gene prognosis model [PDF]
Frontiers in Cell and Developmental BiologyExtrachromosomal DNAs (eccDNAs) frequently carry amplified oncogenes. This investigation aimed to examine the occurrence and role of eccDNAs in individuals diagnosed with advanced perihilar cholangiocarcinoma (pCCA) who exhibited distinct prognostic ...
Shijie Fu +8 more
core +7 more sources
FLED: a full-length eccDNA detector for long-reads sequencing data [PDF]
Briefings in Bioinformatics, 2023 Abstract Reconstructing the full-length sequence of extrachromosomal circular DNA (eccDNA) from short sequencing reads has proved challenging given the similarity of eccDNAs and their corresponding linear DNAs. Previous sequencing methods were unable to achieve high-throughput detection of full-length eccDNAs.
Fu‐Yu Li +6 more
openalex +3 more sources
Extrachromosomal Circular DNA (eccDNA): From Chaos to Function [PDF]
Frontiers in Cell and Developmental Biology, 2022 Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and origin and has been identified in both normal and cancer cells. Although many studies suggested its potential roles in various physiological and pathological procedures ...
Shanru Zuo +8 more
openalex +4 more sources
, 2022 Abstract Evidence for the existence of extrachromosomal circular DNA (eccDNA) was presented decades ago, but only recent technological advancements have allowed a better characterization of eccDNA, including their crucial role in human pathogenesis, which is to increase the copy number and availability of oncogenes. However, the current
Hervé Vanderschuren +5 more
openalex +2 more sources
Extrachromosomal Circular DNA as a Cancer Biomarker: From Diagnosis to Treatment. [PDF]
Cancer InnovExtrachromosomal circular DNA (eccDNA) is an emerging class of genetic material that exists outside the chromosomal genome. These circular DNA molecules are gaining increasing attention as important biomarkers in cancer research due to their roles in gene amplification, genetic heterogeneity, and drug resistance.
Li H, Cai J, Zhao G, Zou L.
europepmc +2 more sources
eccDNAs are apoptotic products with high innate immunostimulatory activity [PDF]
Nature, 2021 Extrachromosomal circular DNA elements (eccDNAs) have been described in the literature for several decades, and are known for their broad existence across different species1,2. However, their biogenesis and functions are largely unknown. By developing a new circular DNA enrichment method, here we purified and sequenced full-length eccDNAs with Nanopore
Yuangao Wang +6 more
openaire +3 more sources
Autonomous replication sequences from the Amaranthus palmeri eccDNA replicon enable replication in yeast [PDF]
BMC Research Notes, 2020 Abstract Objective: The objective of the research presented here was to determine whether autonomous replication sequences (ARS) discovered in the eccDNA replicon of glyphosate resistant Amaranthus palmeri enable self-replication in a yeast system.
William T. Molin +3 more
openalex +6 more sources
The urinary eccDNA landscape in prostate cancer reveals associations with genome instability and vital roles in cancer progression. [PDF]
J Adv ResChen S +8 more
europepmc +2 more sources
eccDNA Atlas: a comprehensive resource of eccDNA catalog
Briefings in Bioinformatics, 2022 AbstractExtrachromosomal circular DNA (eccDNA) represents a large category of nonmitochondrial and nonplasmid circular extrachromosomal DNA playing an indispensable role in various aspects such as tumorigenesis, immune responses, liquid biopsy, etc. However, characteristic and functions of eccDNA are fragmented, hiding behind abundant literatures and ...
Tengwei Zhong +5 more
openaire +2 more sources