Results 31 to 40 of about 1,406 (212)

Unveiling eccDNA Dynamics in Rice: Insights into Adaptation to Nutritional Stress [PDF]

Abstract Extrachromosomal circular DNAs (eccDNAs) have been identified in various eukaryotic organisms and play a crucial role in genomic plasticity. However, in crop plants, the role of eccDNAs in responses to environmental cues, particularly nutritional stresses, remains unexplored. Rice (Oryza sativa ssp.
Luís Herrera‐Estrella, Hanfang Ni, Lenin Yong‐Villalobos, Mian Gu, Damar López‐Arredondo, Min Chen, Liyan Geng, Guohua Xu   +7 more
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A molecular cytogenetic perspective on chromosome biology and crop improvement. [PDF]

Plant Genome
Abstract The age of molecular cytogenetic analysis of crop plants dawned in the late 1960s and early 1970s with new advances in the identification of somatic chromosomes by C‐banding and fluorescence in situ hybridization concurrent with advances in DNA cloning, sequencing, and mapping. In this perspective article dedicated to Ronald Phillips, I review
Gill BS.
europepmc   +2 more sources

Nucleosome-mediated conformational switches in micro-eccDNAs

ABSTRACTExtrachromosomal-circular DNA (eccDNA) are circular-DNA elements that are implicated in cellular processes such as genomic diversification and instability, along with other genomic mechanisms. However, their structure and chromatinization state is poorly understood.
Sarah A. Harris, Victor Velasco-Berrelleza, William Sandel, Thana Sutthibutpong, Victoria N. Parikh, Euan A. Ashley, Andrew Fire, Stephen D. Levene, Thomas C. Bishop, Massa J. Shoura   +9 more
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Integrative profiling of extrachromosomal circular DNA in placenta and maternal plasma provides insights into the biology of fetal growth restriction and reveals potential biomarkers

Frontiers in Genetics, 2023
Introduction: Fetal growth restriction (FGR) is a placenta-mediated pregnancy complication that predisposes fetuses to perinatal complications. Maternal plasma cell-free DNA harbors DNA originating from placental trophoblasts, which is promising for the ...
Minhuan Lin, Yiqing Chen, Shuting Xia, Zhiming He, Xuegao Yu, Linhuan Huang, Shaobin Lin, Binrun Liang, Ziliang Huang, Shiqiang Mei, Dong Liu, Lingling Zheng, Yanmin Luo   +12 more
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CircleBase: an integrated resource and analysis platform for human eccDNAs [PDF]

Nucleic Acids Research, 2021
AbstractRapid advances in high-throughput sequencing technologies have led to the discovery of thousands of extrachromosomal circular DNAs (eccDNAs) in the human genome. Loss-of-function experiments are difficult to conduct on circular and linear chromosomes, as they usually overlap.
Xiaolu Zhao, Leisheng Shi, Shasha Ruan, Wenjian Bi, Yifan Chen, Lin Chen, Yifan Liu, Mingkun Li, Jie Qiao, Fengbiao Mao   +9 more
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EccDNA-oriented ITGB7 expression in breast cancer

Annals of Translational Medicine, 2022
Extrachromosomal circular DNA (eccDNA) is omnipresent in cancers and related to the progression of tumors and oncogene amplification. However, its function in breast cancer (BC) is unclear.After constructing the DNA library, CLeavage Effects by Circularization for In vitro Reporting of sequencing was performed for eccDNA detection using 1 BC tissue ...
Yang, Lin, Wang, Meixue, Hu, Xi’e, Yuan, Lijuan, Chen, Songhao, Peng, Shujia, Yang, Ping, Yang, Zhenyu, Bao, Guoqiang, He, Xianli   +9 more
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Investigating retrotransposon‐derived DNA and activation of the innate immune response in tauopathy [PDF]

Alzheimers Dement
Abstract Background Extrachromosomal circular DNA (eccDNA) was extracted from post‐mortem human brain with tauopathy and sequenced. Cytosolic DNA binding proteins and their RNA transcripts were quantified in induced pluripotent stem cells (iPSCs) with tauopathy. Method DNA was extracted from frontal cortex of Alzheimer's disease Braak III and Braak VI,
Lambert M, Ramirez P, Sun W, Frost B.
europepmc   +2 more sources

eccDB: a comprehensive repository for eccDNA-mediated chromatin contacts in multi-species [PDF]

Bioinformatics, 2022
Abstract Summary We developed the eccDB database to integrate available resources for extrachromosomal circular DNA (eccDNA) data. eccDB is a comprehensive repository for storing, browsing, searching, and analyzing eccDNAs from multispecies.
Min Yang, Bo Qiu, Guoyou He, Jianyuan Zhou, Haojie Yu, Yuying Zhang, Yan-Shang Li, Tai-Song Li, Jincheng Guo, Xuecang Li, Jian‐Jun Xie   +10 more
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The characteristics of extrachromosomal circular DNA in patients with end-stage renal disease

European Journal of Medical Research, 2023
Background End-stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD). In addition to the structurally intact chromosome genomic DNA, there is a double-stranded circular DNA called extrachromosomal circular DNA (eccDNA), which is ...
Yue Peng, Yixi Li, Wei Zhang, Yu ShangGuan, Ting Xie, Kang Wang, Jing Qiu, Wenjun Pu, Biying Hu, Xinzhou Zhang, Lianghong Yin, Donge Tang, Yong Dai   +12 more
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Cell-Free Genic Extrachromosomal Circular DNA Profiles of DNase Knockouts Associated with Systemic Lupus Erythematosus and Relation with Common Fragile Sites

Biomedicines, 2023
Cell-free extrachromosomal circular DNA (cf-eccDNA) has been proposed as a promising early biomarker for disease diagnosis, progression and drug response.
Daniela Gerovska, Patricia Fernández Moreno, Aitor Zabala, Marcos J. Araúzo-Bravo   +3 more
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