Results 31 to 40 of about 1,090 (186)
Purification, full-length sequencing and genomic origin mapping of eccDNA
Nature Protocols, 2022 A protocol for purification, full-length sequencing and genomic origin mapping of extrachromosomal circle DNA using a three-step purification strategy combined with rolling-circle amplification and Oxford Nanopore sequencing.
Yuangao Wang, Meng Wang, Y. Zhang
semanticscholar +3 more sources
Replication independent formation of extrachromosomal circular DNA in mammalian cell-free system. [PDF]
PLoS ONE, 2009 Extrachromosomal circular DNA (eccDNA) is a pool of circular double stranded DNA molecules found in all eukaryotic cells and composed of repeated chromosomal sequences. It was proposed to be involved in genomic instability, aging and alternative telomere
Zoya Cohen, Sara Lavi
doaj +5 more sources
Cell Death Discovery, 2022 Elevated extrachromosomal circular DNA (eccDNA) has been reported to accelerate tumor pathogenesis. Although the eccDNA profiles of other tumors have been established, the landscape of the eccDNA of acute myeloid leukemia (AML) has not been revealed. Our
Tiansheng Zeng +15 more
semanticscholar +4 more sources
Identification and characterization of eccDNA-driven genes in humans
PLOS OneExtrachromosomal circular DNA (eccDNA) amplification promotes oncogene expression and cancer development. However, the global transcriptional landscape mediated by eccDNA has not yet been extensively profiled. Here we report a comprehensive analysis spanning cancer, non-cancerous disease and health by developing a new approach to catalog eccDNA-driven ...
Yuxi Gu, Yidan Song, Jun Liu
openalex +3 more sources
Pest Management Science, EarlyView.In this study, multiple herbicide resistant mechanisms have been confirmed in two Amaranthus palmeri populations from Spain that survived glyphosate‐ and ALS‐inhibitor herbicides. Our data suggest that the eccDNA and the mutations identified in the ALS gene are the result of an evolutionary event that occurred outside Spain.
Alfredo Manicardi +5 more
openalex +2 more sources
Advanced Science, Volume 12, Issue 25, July 3, 2025.Extrachromosomal Circular DNA In article number 2501934, Bin Shi, Shuyu Zhang, and co‐workers present the increased existence of eccDNA induced by ionizing radiation. VPS41 gene in the eccDNA confers protection against genotoxic stress. This study highlights the role of eccDNA in cellular defense, providing strategies to enhance tissue resilience to ...
Bin Shi +12 more
openalex +2 more sources
scEccDNAdb: an integrated single-cell eccDNA resource for human and mouse
DatabaseExtrachromosomal circular DNA (eccDNA), an extrachromosomal circular structured DNA, is extensively found in eukaryotes. Exploring eccDNA at the single-cell level contributes to understanding heterogeneity, evolution, development, and specific functions ...
Wenqing Wang +5 more
semanticscholar +3 more sources
PLoS BiologyExtrachromosomal circular DNA (eccDNA) has been described in several eukaryotic species and has been shown to impact phenomena as diverse as cancer and herbicide tolerance. EccDNA is thought to arise mainly through transposable element (TE) mobilization.
Syed Shan‐e‐Ali Zaidi +6 more
openalex +2 more sources
Autonomous replication sequences from the Amaranthus palmeri eccDNA replicon enable replication in yeast [PDF]
BMC Research Notes, 2020 Abstract Objective: The objective of the research presented here was to determine whether autonomous replication sequences (ARS) discovered in the eccDNA replicon of glyphosate resistant Amaranthus palmeri enable self-replication in a yeast system.
William T. Molin +3 more
openalex +6 more sources
Investigating cellular heterogeneity at the single-cell level by the flexible and mobile extrachromosomal circular DNA [PDF]
Computational and Structural Biotechnology Journal, 2023 Extrachromosomal circular DNA (eccDNA) is a special class of DNA derived from linear chromosomes. It coexists independently with linear chromosomes in the nucleus.
Jiajinlong Kang +4 more
doaj +2 more sources