Results 41 to 50 of about 1,090 (186)

Cell-Free eccDNAs: A New Type of Nucleic Acid Component for Liquid Biopsy? [PDF]

Molecular Diagnosis & Therapy, 2018
Extrachromosomal circular DNAs (eccDNAs) are circular DNAs that are originated from chromosomes, but are independent from chromosomal DNA. The eccDNAs are commonly found in various tissues and cell types, and in both normal and diseased conditions. Due to their highly heterogeneous origins and being widely spread in nearly all eukaryotes, the eccDNAs ...
Jing Zhu, Siyu Chen, Fan Zhang, Liang Wang   +3 more
openalex   +4 more sources

Extrachromosomal circles of satellite repeats and 5S ribosomal DNA in human cells [PDF]

Mobile DNA, 2010
Background Extrachomosomal circular DNA (eccDNA) is ubiquitous in eukaryotic organisms and was detected in every organism tested, including in humans. A two-dimensional gel electrophoresis facilitates the detection of eccDNA in preparations of genomic ...
Cohen Sarit, Agmon Neta, Sobol Olga, Segal Daniel   +3 more
doaj   +4 more sources

Survey of extrachromosomal circular DNA derived from plant satellite repeats [PDF]

BMC Plant Biology, 2008
Background Satellite repeats represent one of the most dynamic components of higher plant genomes, undergoing rapid evolutionary changes of their nucleotide sequences and abundance in a genome.
Macas Jiří, Koblížková Andrea, Navrátilová Alice   +2 more
doaj   +5 more sources

Circle-seq reveals that eccDNA may be a key blood biomarker for HBV-associated liver cancer

Frontiers in Genetics
Introduction Extrachromosomal circular DNA (eccDNA) regulates tumor occurrence and development. Relevant eccDNA profiles have been established for various types of cancer; however, the eccDNA expression profiles in the blood of patients with ...
Ran Xia, Xiao fang Zhao, Zhaoxia Wei, Hua Pang, Yan Tang, Rong Liu, T. Wu, Xu D. Liu   +7 more
openalex   +2 more sources

Identification of eccDNA in Extracellular Vesicles Derived from Human Dermal Fibroblasts Through Nanopore Sequencing

International Journal of Molecular Sciences
Extrachromosomal circular DNAs (eccDNAs) are heterogeneous circular DNA molecules derived from genomic DNA, and believed to be involved in intercellular communication and in natural biological processes.
Bianca Simonassi-Paiva, José Magno Queiroz Luz, Julia Hellena Mendes Ribeiro, Juliano Coelho da Silveira, Cíntia Ávila Souza, Γεώργιος Παππάς, Juliana Lott Carvalho, Mark Lynch, Robert Pogue, Neil J. Rowan   +9 more
openalex   +2 more sources

eccDNAs are apoptotic products with high innate immunostimulatory activity [PDF]

Nature, 2021
Extrachromosomal circular DNA elements (eccDNAs) have been described in the literature for several decades, and are known for their broad existence across different species1,2. However, their biogenesis and functions are largely unknown. By developing a new circular DNA enrichment method, here we purified and sequenced full-length eccDNAs with Nanopore
Yuangao Wang, Yuangao Wang, Yi Zhang, Meng Wang, Meng Wang, Di Liu, Di Liu, Frederick W. Alt, Frederick W. Alt, Frederick W. Alt, Mohamed Nadhir Djekidel, Mohamed Nadhir Djekidel, Huan Chen, Huan Chen   +13 more
openaire   +4 more sources

Integrative profiling of extrachromosomal circular DNA in placenta and maternal plasma provides insights into the biology of fetal growth restriction and reveals potential biomarkers

Frontiers in Genetics, 2023
Introduction: Fetal growth restriction (FGR) is a placenta-mediated pregnancy complication that predisposes fetuses to perinatal complications. Maternal plasma cell-free DNA harbors DNA originating from placental trophoblasts, which is promising for the ...
Minhuan Lin, Yiqing Chen, Shuting Xia, Zhiming He, Xuegao Yu, Linhuan Huang, Shaobin Lin, Binrun Liang, Ziliang Huang, Shiqiang Mei, Dong Liu, Lingling Zheng, Yanmin Luo   +12 more
doaj   +1 more source

Cell-Free Genic Extrachromosomal Circular DNA Profiles of DNase Knockouts Associated with Systemic Lupus Erythematosus and Relation with Common Fragile Sites

Biomedicines, 2023
Cell-free extrachromosomal circular DNA (cf-eccDNA) has been proposed as a promising early biomarker for disease diagnosis, progression and drug response.
Daniela Gerovska, Patricia Fernández Moreno, Aitor Zabala, Marcos J. Araúzo-Bravo   +3 more
doaj   +1 more source

The characteristics of extrachromosomal circular DNA in patients with end-stage renal disease

European Journal of Medical Research, 2023
Background End-stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD). In addition to the structurally intact chromosome genomic DNA, there is a double-stranded circular DNA called extrachromosomal circular DNA (eccDNA), which is ...
Yue Peng, Yixi Li, Wei Zhang, Yu ShangGuan, Ting Xie, Kang Wang, Jing Qiu, Wenjun Pu, Biying Hu, Xinzhou Zhang, Lianghong Yin, Donge Tang, Yong Dai   +12 more
doaj   +1 more source

Sequence Characterization of Extra-Chromosomal Circular DNA Content in Multiple Blackgrass (Alopecurus myosuroides) Populations. [PDF]

, 2023
Alopecurus myosuroides (blackgrass) is a problematic weed of Western European winter wheat, and its success is largely due to widespread multiple-herbicide resistance. Previous analysis of F2 seed families derived from two distinct blackgrass populations
Comont, D., Fu, W., Macgregor, D., Saski, C. A.   +3 more
core   +1 more source