Results 41 to 50 of about 1,406 (212)

Variation of extrachromosomal circular DNA in cancer cell lines

Computational and Structural Biotechnology Journal, 2023
The presence of oncogene carrying eccDNAs is strongly associated with carcinogenesis and poor patient survival. Tumour biopsies and in vitro cancer cell lines are frequently utilized as models to investigate the role of eccDNA in cancer. However, eccDNAs
Carl Rung dos Santos, Lasse Bøllehuus Hansen, Monica Rojas-Triana, Astrid Zedlitz Johansen, Mirna Perez-Moreno, Birgitte Regenberg   +5 more
doaj   +1 more source

CircleBase V2: an eccDNA annotation platform across cancers and species. [PDF]

Nucleic Acids Res
Abstract CircleBase V2 (http://circlebase2.maolab.org) is a comprehensive update of our previously developed database, offering a significantly expanded and functionally enhanced resource for investigating extrachromosomal circular DNA (eccDNA) in human and mouse.
Wei L, Shi L, Wu N, Zhao H, Wubulikasimu Z, Liu K, Deng M, Mao F, Xiang X, Bi H, Zhao X.   +10 more
europepmc   +2 more sources

Analysis of multiple-herbicide resistant Amaranthus palmeri populations from Spain points to an introduction of the eccDNA from America. [PDF]

Pest Manag Sci
In this study, multiple herbicide resistant mechanisms have been confirmed in two Amaranthus palmeri populations from Spain that survived glyphosate‐ and ALS‐inhibitor herbicides. Our data suggest that the eccDNA and the mutations identified in the ALS gene are the result of an evolutionary event that occurred outside Spain.
Manicardi A, Mora G, Araujo ALS, Gaines TA, Lozano-Juste J, Torra J.   +5 more
europepmc   +2 more sources

BRIGHT Enables High-SNR Live-Cell Imaging of Non-Repetitive Sequences via Bivalent Fluorescent Nanobody-Mediated Cascade-Dependent Illumination. [PDF]

Adv Sci (Weinh)
BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Feng L, Huang T, Han Y, Tian M, Wang D, Mei Z, Ma Y, Ma Y, Li J, Zhang R.   +9 more
europepmc   +2 more sources

Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer [PDF]

Molecular Cancer, 2021
AbstractExtrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from but are likely independent of chromosomes. Due to technological advancements, eccDNAs have recently emerged as multifunctional molecules with numerous characteristics. The unique topological structure and genetic characteristics of eccDNAs shed new light
Xiaoxuan Ling, Yali Han, Jinxue Meng, Bohuan Zhong, Jialong Chen, He Zhang, Jiheng Qin, Jing Pang, Linhua Liu   +8 more
openaire   +3 more sources

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications. [PDF]

Cell Prolif
ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Li J, Luo P, Li Z, Wang Q, Huang X, Huang X, Wang K, Wang R, Chen R.   +8 more
europepmc   +2 more sources

Cisplatin-induced WWP1-eccDNA expression contributes to ovarian cancer resistance [PDF]

Advances in Clinical and Experimental Medicine
Chenyang Lu, Li Han, Xiang Guo, Rong Du, Hui Zhang, Kun Guo, Yi Tu, Ruifang Li   +7 more
openalex   +2 more sources

Identification and characterization of extrachromosomal circular DNA in patients with high myopia and cataract

Epigenetics, 2023
To explore the presence of extrachromosomal circular DNA (eccDNA) in the anterior capsule of the lens in the eyes of patients with cataract and with high myopia.
Kai Wen, Lujie Zhang, Yang Cai, He Teng, Jingli Liang, Yi Yue, Yaoling Li, Yifang Huang, Ming Liu, Yufeng Zhang, Ruihua Wei, Jing Sun   +11 more
doaj   +1 more source

EccDNA Analysis Provides Novel Insights Into the Molecular Mechanism of Firmness of Fish Fillet. [PDF]

Food Sci Nutr
We provide a new and basic eccDNA database for the molecular regulation of muscle firmness in grass carp. The eccDNA abundance in crisp grass carp was significantly higher than that in ordinary grass carp. EccDNAs likely play important roles in the muscle‐hardening of crisp grass carp.
Zhang K, Chen J, He H, Duan B, You C, Hu Z, Cai L, Xiang X, Liang R.   +8 more
europepmc   +2 more sources

Extrachromosomal DNA in Genome (in)Stability – Role of Telomeres [PDF]

, 2016
Eukaryotic genome consists of long linear chromosomes. It is complex in its content and has dynamic features. It mostly consists of non-coding DNA of various repeats, often prone to recombination including creation of extrachromosomal DNA which can be re-
Nanić, Lucia, Ravlić, Sanda, Rubelj, Ivica   +2 more
core   +3 more sources