Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2-Mediated Transcriptional Network in Multiple Myeloma. [PDF]
Adv Sci (Weinh)Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Chen B +12 more
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Plants, 2023 Extrachromosomal circular DNAs (eccDNAs) are enigmatic DNA molecules that have been detected in a range of organisms. In plants, eccDNAs have various genomic origins and may be derived from transposable elements.
Pavel Merkulov +2 more
doaj +1 more source
Association analysis of A20 eccDNA mRNA in B-cell lymphoma cells and its application in the study of platinum nanoenzyme therapy mechanism [PDF]
Diffuse large B-cell lymphoma (DLBCL) is a common but difficult to treat type of non Hodgkin lymphoma. At present, platinum nanoparticles with enzyme mimicking activity - platinum nanoenzymes - have been well applied in the treatment of DLBCL disease ...
Lei Zhao +5 more
openalex +3 more sources
Survey of extrachromosomal circular DNA derived from plant satellite repeats [PDF]
, 2008 Background Satellite repeats represent one of the most dynamic components of higher plant genomes, undergoing rapid evolutionary changes of their nucleotide sequences and abundance in a genome.
Koblížková, Andrea +2 more
core +3 more sources
Clinical and Translational Medicine, 2023 Background Extrachromosomal circular DNA (eccDNA) has emerged as a promising biomarker for disease diagnosis and prognosis prediction. However, its role in type 2 diabetes remains unexplored.
Zhe Xu +15 more
doaj +1 more source
Investigating the origins and evolution of a glyphosate-resistant weed invasion in South America [PDF]
, 2021 The global invasion, and subsequent spread and evolution of weeds provides unique opportunities to address fundamental questions in evolutionary and invasion ecology. Amaranthus palmeri is a widespread glyphosate-resistant (GR) weed in the USA.
Gaines, Todd A +9 more
core +2 more sources
Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
Frontiers in Veterinary Science, 2021 Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin.
Xiukai Cao +6 more
doaj +1 more source
The potential clinical implications of extrachromosomal circular DNA as a biomarker
Genes and DiseasesExtrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from and are independent of conventional chromosomes. The high specificity and stability of the circular structure of eccDNA provide new clues for its research as ...
Xuanmei Luo +4 more
doaj +1 more source
Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation [PDF]
Molecular Cancer Research, 2017 Abstract Cell-free circulating linear DNA is being explored for noninvasive diagnosis and management of tumors and fetuses, the so-called liquid biopsy. Previously, we observed the presence of small extrachromosomal circular DNA (eccDNA), called microDNA, in the nuclei of mammalian tissues and cell lines. Now, we demonstrate that cell-
Pankaj, Kumar +5 more
openaire +2 more sources
That's no moon, it's a Starship:Giant transposons driving fungal horizontal gene transfer [PDF]
, 2023 To date, most reports of horizontal gene transfer (HGT) in fungi rely on genome sequence data and are therefore an indirect measure of HGT after the event has occurred. However, a novel group of class II‐like transposons known as Starships may soon alter
Bucknell, Angus, McDonald, Megan
core +1 more source