Results 61 to 70 of about 1,090 (186)
Extrachromosomal circular DNA: Current status and future prospects
eLife, 2022 Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases.
Yiheng Zhao +4 more
doaj +1 more source
Evidence for rolling circle replication of tandem genes in Drosophila [PDF]
, 2005 Extrachromosomal circular DNA (eccDNA) is one characteristic of the plasticity of the eukaryotic genome. It is found in various organisms and contains sequences derived primarily from repetitive chromosomal DNA.
Agmon, Neta +4 more
core +3 more sources
Transcription-induced formation of extrachromosomal DNA during yeast ageing.
PLoS Biology, 2019 Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid and extensive gene copy number variation and is implicated in the pathology of cancer and ageing.
Ryan M Hull +5 more
doaj +1 more source
Plants, 2023 Extrachromosomal circular DNAs (eccDNAs) are enigmatic DNA molecules that have been detected in a range of organisms. In plants, eccDNAs have various genomic origins and may be derived from transposable elements.
Pavel Merkulov +2 more
doaj +1 more source
The Plant Journal, 2022 SUMMARY Long terminal repeat retrotransposons (LTR‐RTs) are mobilized via an RNA intermediate using a ‘copy and paste’ mechanism, and account for the majority of repetitive DNA in plant genomes.
Kornelia Kwolek +6 more
semanticscholar +1 more source
Clinical and Translational Medicine, 2023 Background Extrachromosomal circular DNA (eccDNA) has emerged as a promising biomarker for disease diagnosis and prognosis prediction. However, its role in type 2 diabetes remains unexplored.
Zhe Xu +15 more
doaj +1 more source
Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
Frontiers in Veterinary Science, 2021 Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin.
Xiukai Cao +6 more
doaj +1 more source
Assesment of Structure, Function, and Microevolutionary Dynamics of Extrachromosomal Circular DNA in Chinese Hamster Ovary Cells [PDF]
, 2023 Chinese hamster ovary (CHO) cell lines are among the most popular expression hosts used in biopharmaceutical manufacturing due to relative ease of culture, capacity to perform human-like post-translational modifications, and non-susceptibility to viruses.
Chitwood, Dylan
core +1 more source
Variation of extrachromosomal circular DNA in cancer cell lines
Computational and Structural Biotechnology Journal, 2023 The presence of oncogene carrying eccDNAs is strongly associated with carcinogenesis and poor patient survival. Tumour biopsies and in vitro cancer cell lines are frequently utilized as models to investigate the role of eccDNA in cancer. However, eccDNAs
Carl Rung dos Santos +5 more
doaj
Instability and Extrachromosomal Circular DNA Formation at Microsatellites and Unstable DNA Sequences [PDF]
, 2022 We have previously documented our evidence of genetic instabilities at the (Pu/Py)78 and (ATTCT)47 sequences and our reasoning for identifying break-induced replication (BIR) as the mode of repair responsible for the mutations in the DNA flanking the ...
Shanahan, Matilyn M.
core +1 more source