Results 71 to 80 of about 1,090 (186)

eccDNA-pipe: an integrated pipeline for identification, analysis and visualization of extrachromosomal circular DNA from high-throughput sequencing data

Briefings Bioinform.
Extrachromosomal circular DNA (eccDNA) is currently attracting considerable attention from researchers due to its significant impact on tumor biogenesis. High-throughput sequencing (HTS) methods for eccDNA identification are continually evolving. However,
Minghao Fang, Jingwen Fang, Songwen Luo, Ke Liu, Qiaoni Yu, Jiaxuan Yang, Youyang Zhou, Zongkai Li, Ruoming Sun, C. Guo, Kun Qu   +10 more
semanticscholar   +1 more source

Whole-genome sequencing of extrachromosomal circular DNA of cerebrospinal fluid of medulloblastoma

Frontiers in Oncology, 2022
BackgroundMedulloblastoma (MB) is a malignant tumor associated with a poor prognosis in part due to a lack of effective detection methods. Extrachromosomal circular DNA (eccDNA) has been associated with multiple tumors.
Yi Zhu, Zhihui Liu, Yuduo Guo, Shenglun Li, Yanming Qu, Lin Dai, Yujia Chen, Weihai Ning, Hongwei Zhang, Lixin Ma, Lixin Ma   +10 more
doaj   +1 more source

A novel extrachromosomal circular DNA related genes signature for overall survival prediction in patients with ovarian cancer

BMC Medical Genomics, 2023
Objective Ovarian cancer (OV) has a high mortality rate all over the world, and extrachromosomal circular DNA (eccDNA) plays a key role in carcinogenesis.
Ying Zhang, Kexian Dong, Xueyuan Jia, Shuomeng Du, Dong Wang, Liqiang Wang, Han Qu, Shihao Zhu, Yang Wang, Zhao Wang, Shuopeng Zhang, Wenjing Sun, Songbin Fu   +12 more
doaj   +1 more source

ECCFP: a consecutive full pass based bioinformatic analysis for eccDNA identification using Nanopore sequencing data

bioRxiv
TangXuan Zhang, Wang Li, Qingsong Zeng, Jun Zhang, Bin Miao, Mengting Li, Luo Juan, Tianliang Liu, Shifu Chen, Shaogui Wan   +9 more
openalex   +2 more sources

Circular DNA elements of chromosomal origin are common in healthy human somatic tissue [PDF]

, 2018
Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active ...
Halling, Jens Frey, Hansen, Anders Johannes, Lam, Hugo Y. K., Maretty, Lasse, Mohiyuddin, Marghoob, Møller, Henrik Devitt, Pilegaard, Henriette, Plomgaard, Peter, Prada Luengo, Inigo, Regenberg, Birgitte, Sailani, M. Reza, Snyder, Michael P.   +11 more
core   +2 more sources

Formation of extrachromosomal circular DNA from long terminal repeats of retrotransposons in Saccharomyces cerevisiae [PDF]

, 2015
Extrachromosomal circular DNA (eccDNA) derived from chromosomal Ty retrotransposons in yeast can be generated in multiple ways. Ty eccDNA can arise from the circularization of extrachromosomal linear DNA during the transpositional life cycle of ...
Hansen, Anders Johannes, Larsen, Camilla Eggert, Mourier, Tobias, Møller, Henrik D., Parsons, Lance, Regenberg, Birgitte   +5 more
core   +2 more sources

Microhomology-mediated circular DNA formation from oligonucleosomal fragments during spermatogenesis

eLife, 2023
The landscape of extrachromosomal circular DNA (eccDNA) during mammalian spermatogenesis, as well as the biogenesis mechanism, remains to be explored. Here, we revealed widespread eccDNA formation in human sperms and mouse spermatogenesis.
Jun Hu, Zhe Zhang, Sai Xiao, Yalei Cao, Yinghong Chen, Jiaming Weng, Hui Jiang, Wei Li, Jia-Yu Chen, Chao Liu   +9 more
doaj   +1 more source

ECCsplorer: detection of extrachromosomal circular DNA (eccDNA) from NGS data

, 2020
Extrachromosomal circular DNAs (eccDNAs) are ring-like DNA structures physically separated from the chromosomes. They have been reported in a broad range of eukaryotes ranging from around 100 bp to several mega base pairs in size. Most of their functions still remain unknown, however some are associated with stress, cancer or aging whilst certain carry
Mann, Ludwig, Seibt, Kathrin M., Weber, Beatrice, Schmidt, Thomas, Heitkam, Tony   +4 more
openaire   +4 more sources

The extrachromosomal circular DNA atlas of aged and young mouse brains

Scientific Data
Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation ...
Xiaoning Hong, Jing Li, Peng Han, Shaofu Li, Jiaying Yu, Haoran Zhang, Jiang Li, Yonghui Dang, Xi Xiang   +8 more
doaj   +1 more source

Extrachromosomal circular DNA: a new potential role in cancer progression

Journal of Translational Medicine, 2021
Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles),
Tianyi Wang, Haijian Zhang, Youlang Zhou, Jiahai Shi   +3 more
doaj   +1 more source