Results 71 to 80 of about 1,406 (212)
BMC Medical Genomics, 2023 Objective Ovarian cancer (OV) has a high mortality rate all over the world, and extrachromosomal circular DNA (eccDNA) plays a key role in carcinogenesis.
Ying Zhang +12 more
doaj +1 more source
Whole-genome sequencing of extrachromosomal circular DNA of cerebrospinal fluid of medulloblastoma
Frontiers in Oncology, 2022 BackgroundMedulloblastoma (MB) is a malignant tumor associated with a poor prognosis in part due to a lack of effective detection methods. Extrachromosomal circular DNA (eccDNA) has been associated with multiple tumors.
Yi Zhu +10 more
doaj +1 more source
DNA Instability at (ATTCT) Microsatellites in Human Cells [PDF]
, 2023 Microsatellites are short tandem repeats of DNA (1-9 nucleotides) that are unstable in the genome. They can expand and contract which leads to mutations and rearrangements that jeopardize genomic integrity. When encountered by a replication fork, repeats
Alhawach, Venicia
core +1 more source
eccDNAMamba: A Pre-Trained Model for Ultra-Long eccDNA Sequence Analysis [PDF]
Accepted by ICML 2025 Generative AI and Biology (GenBio ...
Zhenke Liu, Jonathan Li, Ziqi Zhang
openalex +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The extrachromosomal circular DNA atlas of aged and young mouse brains
Scientific DataExtrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation ...
Xiaoning Hong +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Assesment of Structure, Function, and Microevolutionary Dynamics of Extrachromosomal Circular DNA in Chinese Hamster Ovary Cells [PDF]
, 2023 Chinese hamster ovary (CHO) cell lines are among the most popular expression hosts used in biopharmaceutical manufacturing due to relative ease of culture, capacity to perform human-like post-translational modifications, and non-susceptibility to viruses.
Chitwood, Dylan
core +1 more source
LifeExtrachromosomal circular DNA (eccDNA) is a form of a circular double-stranded DNA that exists independently of conventional chromosomes. eccDNA exhibits a broad and random distribution across eukaryotic cells and has been associated with tumor-related ...
Panagiotis Tsiakanikas +6 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source