Results 81 to 90 of about 1,406 (212)
Microhomology-mediated circular DNA formation from oligonucleosomal fragments during spermatogenesis
eLife, 2023 The landscape of extrachromosomal circular DNA (eccDNA) during mammalian spermatogenesis, as well as the biogenesis mechanism, remains to be explored. Here, we revealed widespread eccDNA formation in human sperms and mouse spermatogenesis.
Jun Hu +9 more
doaj +1 more source
Yanke Xuebao[Objective:] To perform full-length sequencing of extrachromosomal circular DNA (eccDNA) in the lens capsule of patients with human immunodeficiency virus (HIV)-infected complicated cataract (CC) and age-related cataract (ARC).
LIU Xinqi +5 more
doaj +1 more source
Extrachromosomal circular DNA: a new potential role in cancer progression
Journal of Translational Medicine, 2021 Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles),
Tianyi Wang +3 more
doaj +1 more source
Instability and Extrachromosomal Circular DNA Formation at Microsatellites and Unstable DNA Sequences [PDF]
, 2022 We have previously documented our evidence of genetic instabilities at the (Pu/Py)78 and (ATTCT)47 sequences and our reasoning for identifying break-induced replication (BIR) as the mode of repair responsible for the mutations in the DNA flanking the ...
Shanahan, Matilyn M.
core +1 more source
Research Advances of Extrachromosomal Circular DNA in Breast Cancer
Cancer Medicine, Volume 14, Issue 19, October 2025.ABSTRACT Background This article presents an extensive review of the advancements in research concerning extrachromosomal circular DNA (ecDNA) within the context of breast cancer. As a distinct form of DNA, ecDNA is critically involved in the initiation, progression, diagnosis, and treatment of breast cancer.
Xiaodan Zhu +6 more
wiley +1 more source
Formation of extrachromosomal circular DNA from long terminal repeats of retrotransposons in Saccharomyces cerevisiae [PDF]
, 2015 Extrachromosomal circular DNA (eccDNA) derived from chromosomal Ty retrotransposons in yeast can be generated in multiple ways. Ty eccDNA can arise from the circularization of extrachromosomal linear DNA during the transpositional life cycle of ...
Hansen, Anders Johannes +5 more
core +2 more sources
Circular DNA elements of chromosomal origin are common in healthy human somatic tissue [PDF]
, 2018 Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active ...
Halling, Jens Frey +11 more
core +2 more sources
, 2023 Alopecurus myosuroides (blackgrass) is a problematic weed of Western European winter wheat and its success is largely due to widespread multiple-herbicide resistance. Previous analysis of F2 seed families derived from two distinct blackgrass populations exhibiting equivalent non-target site resistance (NTSR) phenotypes shows resistance is polygenic and
Wanfang Fu +3 more
openaire +1 more source
ECCsplorer: detection of extrachromosomal circular DNA (eccDNA) from NGS data
, 2020 Extrachromosomal circular DNAs (eccDNAs) are ring-like DNA structures physically separated from the chromosomes. They have been reported in a broad range of eukaryotes ranging from around 100 bp to several mega base pairs in size. Most of their functions still remain unknown, however some are associated with stress, cancer or aging whilst certain carry
Mann, Ludwig +4 more
openaire +2 more sources
Cancer Medicine, 2023 Backgrounds Despite recent advances, many cancers are still detected too late for curative treatment. There is, therefore, a need for the development of new diagnostic methods and biomarkers.
Lasse Bøllehuus Hansen +8 more
doaj +1 more source