Results 81 to 90 of about 1,090 (186)

Profiling of eccDNAs in Arabidopsis indicates shift in population of TE-derived eccDNAs in response to stress, cellular state,and epigenetic processes

, 2022
Abstract Evidence for the existence of extrachromosomal circular DNA (eccDNA) was presented decades ago, but only recent technological advancements have allowed a better characterization of eccDNA, including their crucial role in human pathogenesis, which is to increase the copy number and availability of oncogenes.
Herve Vanderschuren, Syed Shan-e-Ali Zaidi, Sara Shakir, Devang Mehta, Vu Nguyen, Ruben Gutzat   +5 more
openaire   +1 more source

Characterization of extrachromosomal circular DNA (eccDNA) structure, function, and dynamics in a CHO K-1 clone [PDF]

, 2023
Please click Additional Files below to see the full ...
Chitwood, Dylan, Green, Kiana, Harcum, Sarah W., Klaubert, Stephanie R., Saski, Christopher A., Wang, Qinghua, Wu, Cathy   +6 more
core   +1 more source

Methods for the purification and detection of single nucleotide KRAS mutations on extrachromosomal circular DNA in human plasma

Cancer Medicine, 2023
Backgrounds Despite recent advances, many cancers are still detected too late for curative treatment. There is, therefore, a need for the development of new diagnostic methods and biomarkers.
Lasse Bøllehuus Hansen, Sandra Fugl Jakobsen, Egija Zole, Julie Boertmann Noer, Li Tai Fang, Sefa Alizadeh, Julia Sidenius Johansen, Marghoob Mohiyuddin, Birgitte Regenberg   +8 more
doaj   +1 more source

ATAC-Seq-based Identification of Extrachromosomal Circular DNA in Mammalian Cells and Its Validation Using Inverse PCR and FISH

Bio-Protocol, 2021
Recent studies from multiple labs including ours have demonstrated the importance of extrachromosomal circular DNA (eccDNA) from yeast to humans (Shibata et al., 2012; Dillon et al., 2015; Møller et al., 2016; Kumar et al., 2017; Turner et al., 2017; Kim
Zhangli Su, Shekhar Saha, Teressa Paulsen, Pankaj Kumar, Anindya Dutta   +4 more
doaj   +1 more source

Molecular mechanisms of adaptive evolution revealed by global selection for glyphosate resistance [PDF]

, 2019
The human‐directed, global selection for glyphosate resistance in weeds has revealed a fascinating diversity of evolved resistance mechanisms, including herbicide sequestration in the vacuole, a rapid cell death response, nucleotide polymorphisms in the ...
Gaines, T. A., Neve, P., Patterson, E. L.   +2 more
core   +1 more source

Holocentromeres can consist of merely a few megabase-sized satellite arrays [PDF]

, 2023
The centromere is the chromosome region where microtubules attach during cell division. In contrast to monocentric chromosomes with one centromere, holocentric species usually distribute hundreds of centromere units along the entire chromatid.
Abel, Simone, Chen, Jianyong, Câmara, Amanda Souza, Demidov, Dmitri, Dunemann, Frank, Fuchs, Jörg, Himmelbach, Axel, Houben, Andreas, Huettel, Bruno, Ishii, Takayoshi, Klocke, Evelyn, Kuo, Yi-Tzu, Macas, Jiří, Marques, André, Mascher, Martin, Melzer, Michael, Neumann, Pavel, Schubert, Veit   +17 more
core   +1 more source

Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications

Frontiers in Oncology, 2023
Chemotherapy is widely used to treat patients with cancer. However, resistance to chemotherapeutic drugs remains a major clinical concern. The mechanisms of cancer drug resistance are extremely complex and involve such factors such as genomic instability,
Juanjuan Luo, Juanjuan Luo, Ying Li, Tangxuan Zhang, Tianhan Xv, Chao Chen, Mengting Li, Qixiang Qiu, Yusheng Song, Shaogui Wan, Shaogui Wan   +10 more
doaj   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures

Cell & Bioscience
Background Extrachromosomal circular DNA (eccDNA) is crucial for carcinogenesis and bile has direct contact with malignant biliary strictures, yet eccDNA features in bile and its function in malignant biliary strictures remain underexplored.
Zhuo Cheng, Xuanmei Luo, Wenzheng Liu, Xiaofang Lu, Hong Chang, Yingchun Wang, Wei Zheng, Xiue Yan, Yonghui Huang   +8 more
doaj   +1 more source

Extrachromosomal circular DNA and structural variants highlight genome instability in Arabidopsis epigenetic mutants

Nature Communications, 2023
Abundant extrachromosomal circular DNA (eccDNA) is associated with transposable element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic regulations and what is its impact on the genome is understudied.
Panpan Zhang, Assane Mbodj, Abirami Soundiramourtty, Christel Llauro, Alain Ghesquière, Mathieu Ingouff, R. Keith Slotkin, Frédéric Pontvianne, Marco Catoni, Marie Mirouze   +9 more
doaj   +1 more source