Results 71 to 80 of about 1,079 (169)

Genexpressionsprofile beim Porokarzinom deuten auf heterogene Tumorentwicklung hin und untermauern Porome als Vorläuferläsionen

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 22, Issue 8, Page 1115-1125, August 2024.
Zusammenfassung Hintergrund und Ziele Maligne Schweißdrüsentumoren sind selten, wobei das ekkrine Porokarzinom (EP) das häufigste ist. Etwa 18 % der benignen ekkrinen Porome (EPO) entwickeln sich zum EP. Wissenschaftliche Studien haben erste Einblicke in die Mutationslandschaft von EPs geliefert.
Svenja Holst   +14 more
wiley   +1 more source

Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report

open access: yesJournal of Medical Case Reports, 2010
Introduction Cutaneous eccrine porocarcinomas are uncommon malignant tumors of the sweat gland. Case Presentation A 76-year-old Caucasian man presented to our hospital with a left temporal mass. We describe a case of eccrine porocarcinoma with metastasis
Lentsch Eric J   +4 more
doaj   +1 more source

Primary cutaneous NUT carcinoma with BRD4::NUTM1 fusion

open access: yesJournal of Cutaneous Pathology, Volume 51, Issue 6, Page 424-429, June 2024.
Abstract Nuclear protein in testis (NUT) carcinoma, molecularly defined by the NUTM1 gene rearrangement, is most commonly reported in young adults in the sinonasal tract, nasopharynx, or thorax. At these sites, NUT carcinoma is an extremely aggressive malignancy with dismal prognosis. Recently, five cases of primary cutaneous NUT adnexal carcinoma have
Ahmed Shah   +3 more
wiley   +1 more source

TGFβ‐induced EN1 promotes tumor budding of adenoid cystic carcinoma in patient‐derived organoid model

open access: yesInternational Journal of Cancer, Volume 154, Issue 10, Page 1814-1827, 15 May 2024.
What's new? Accurate diagnosis of adenoid cystic carcinoma (ACC) often requires distinction from basal cell adenoma (BCA). Diagnostic markers capable of differentiating ACC from BCA, however, are lacking. Here, the authors investigated the diagnostic potential of homeobox transcription factor EN1.
Zhixuan Hui   +7 more
wiley   +1 more source

Porocarcinoma scalp with high risk features treated with surgery and adjuvant radiotherapy: A case report and review of literature

open access: yesJournal of the Egyptian National Cancer Institute, 2016
Eccrine porocarcinoma is a rare malignant sweat gland tumor arising from the intra dermal part of the gland and accounts for only 0.005% of all epithelial cutaneous tumors. Commonly involved site includes extremities and face.
Wineeta Melgandi   +3 more
doaj   +1 more source

Papular lesion occurring within a longstanding warty plaque, in skin of colour Fitzpatrick type 4–5

open access: yesSkin Health and Disease, Volume 4, Issue 2, April 2024.
Sebaceous naevi (SN), also known as naevus sebaceous of Jadassohn, are benign hamartomatous malformations comprised of predominantly sebaceous glands. Malignant neoplasms occurring within SN almost exclusively occur in adults, and arise in about 2.5% of lesions.
Joelle Teoh   +4 more
wiley   +1 more source

A case of recurrent eccrine porocarcinoma

open access: yesChronic Diseases Journal, 2016
BACKGROUND: Eccrine porocarcinoma, first described in 1963, is a rare malignant lesion arising from the eccrine sweat glands. It is usually a primary tumor, even more commonly, a malignant degeneration of an eccrine poroma.
Esmaeil Sadeghi, Mohamad Jafari
doaj   +1 more source

Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells

open access: yesSmall, Volume 20, Issue 16, April 18, 2024.
Beyond its barrier role, skin has thermoregulatory and sensory functions. These functions are facilitated by skin‐associated structures known as skin appendages (such as hair follicles, sweat glands, etc.). In this study, skin organoids with its appendages are developed from human‐induced pluripotent stem cells.
Abbas Shafiee   +9 more
wiley   +1 more source

Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update

open access: yesHistopathology, Volume 84, Issue 2, Page 266-278, January 2024.
Poroma is a benign sweat gland tumour showing morphological features recapitulating the superficial portion of the eccrine sweat coil, porocarcinoma being its malignant counterpart. Recently YAP1::MAML2, YAP1::NUTM1 fusions and PAK2 rearrangements have been identified as recurrent and mutually exclusive oncogenic event in this setting.
Thibault Kervarrec   +12 more
wiley   +1 more source

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