Results 1 to 10 of about 1,012 (140)

Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer [PDF]

Nature Communications
Extrachromosomal circular DNA (ecDNA) has been found in most types of human cancers, and ecDNA incorporating viral genomes has recently been described, specifically in human papillomavirus (HPV)-mediated oropharyngeal cancer (OPC). However, the molecular
Takuya Nakagawa, Jens Luebeck, Kaiyuan Zhu, Joshua T. Lange, Roman Sasik, Chad Phillips, Sayed Sadat, Sara Javadzadeh, Qian Yang, Abdula Monther, Santiago Fassardi, Allen Wang, Kersi Pestonjamasp, Brin Rosenthal, Kathleen M. Fisch, Paul Mischel, Vineet Bafna, Joseph A. Califano   +17 more
doaj   +3 more sources

An EcDNA gene-based risk model and functional verification of a key ec-lncRNA AC016394.2 for prostate cancer [PDF]

Cancer Cell International
Background Prostate cancer(PCa) ranks among the most frequently diagnosed malignancies in men. The progression and heterogeneity of tumors pose significant challenges to clinical prognosis and treatment strategies.
JiangPing Qiu, Jiang Wu, Nan Zhou, Cong Lai, Xin Huang, Cheng Liu, XiaoQing Yuan, Kewei Xu   +7 more
doaj   +3 more sources

WRN Nuclease‐Mediated EcDNA Clearance Enhances Antitumor Therapy in Conjunction with Trehalose Dimycolate/Mesoporous Silica Nanoparticles

Advanced Science
Current research on tumor fibrosis has focused on cancer‐associated fibroblasts, which may exert dual functions of tumor promotion and inhibition. Little attention has been paid to whether tumor cells themselves can undergo fibrotic transformation and ...
Yinan Li, Xiu Huang, Yingying Li, Qingqing Qiao, Caihong Chen, Yang Chen, Weilong Zhong, Huijuan Liu, Tao Sun   +8 more
doaj   +3 more sources

Extrachromosomal DNA (ecDNA): Unveiling its role in cancer progression and implications for early detection [PDF]

Heliyon, 2023
Extrachromosomal DNA (ecDNA) is a special class of circular DNA in eukaryotes, which is independent of conventional chromosomes. These circular molecules play important roles in biology, especially in cancer biology.
Shuhong Wu, Tao Tao, Lin Zhang, Xiao Zhu, Xiaorong Zhou   +4 more
doaj   +2 more sources

Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors [PDF]

eLife, 2023
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna   +6 more
doaj   +4 more sources

ATACAmp: a tool for detecting ecDNA/HSRs from bulk and single-cell ATAC-seq data [PDF]

BMC Genomics, 2023
Background High oncogene expression in cancer cells is a major cause of rapid tumor progression and drug resistance. Recent cancer genome research has shown that oncogenes as well as regulatory elements can be amplified in the form of extrachromosomal ...
Hansen Cheng, Wenhao Ma, Kun Wang, Han Chu, Guangchao Bao, Yu Liao, Yawen Yuan, Yixiong Gou, Liting Dong, Jian Yang, Haoyang Cai   +10 more
doaj   +2 more sources

Single‐cell third‐generation sequencing‐based multi‐omics uncovers gene expression changes governed by ecDNA and structural variants in cancer cells [PDF]

Clinical and Translational Medicine, 2023
Background Cancer cells often exhibit large‐scale genomic variations, such as circular extrachromosomal DNA (ecDNA) and structural variants (SVs), which have been highly correlated with the initiation and progression of cancer.
Lei Chang, Enze Deng, Jun Wang, Wei Zhou, Jian Ao, Rong Liu, Dan Su, Xiaoying Fan   +7 more
doaj   +2 more sources

Resolving spatial subclonal genomic heterogeneity of loss of heterozygosity and extrachromosomal DNA in gliomas [PDF]

Nature Communications
Mapping the spatial organization of DNA-level somatic copy number changes in tumors can provide insight to understanding higher-level molecular and cellular processes that drive pathogenesis. We describe an integrated framework of spatial transcriptomics,
Michelle G. Webb, Frances Chow, Carmel G. McCullough, Bohan Zhang, John J. Y. Lee, Rania Bassiouni, Norman E. Garrett, Kyle Hurth, John D. Carpten, Gabriel Zada, David W. Craig   +10 more
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Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses [PDF]

Frontiers in Pharmacology
IntroductionTraditional drug discovery efforts primarily target rapid, reversible protein-mediated adaptations to counteract cancer cell resistance. However, cancer cells also utilize DNA-based strategies, often perceived as slow, irreversible changes ...
Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk   +18 more
doaj   +2 more sources

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications. [PDF]

Cell Prolif
ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Li J, Luo P, Li Z, Wang Q, Huang X, Huang X, Wang K, Wang R, Chen R.   +8 more
europepmc   +2 more sources