Results 91 to 100 of about 2,326 (226)

Mapping extrachromosomal DNA amplifications during cancer progression. [PDF]

To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression, we detected and classified focal amplifications in 8,060 newly diagnosed primary cancers, untreated metastases and heavily pretreated tumors.
An, Sepil, Bafna, Vineet, Chung, Heesuk, Golebiewska, Anna, Johnson, Kevin C, Kang, Seunghyun, Kim, Hoon, Kim, Soyeon, Ko, Junyong, Lee, Hwa Yeon, Lipsa, Anuja, Luebeck, Jens, Moon, Hyo-Eun, Nam, Yoonjoo, Niclou, Simone P, Paek, Sun Ha, Verhaak, Roel G W, Wade, Taylor E, Yeo, Eunchae   +18 more
core   +2 more sources

Single‐Cell Multi‐Omics Reveals B2M‐Mediated Myeloid Reprogramming and Constructs a Predictive Model for Early Hepatocellular Carcinoma Recurrence

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
Single‐cell multi‐omics integration reveals that B2M‐mediated immune reprogramming drives early HCC recurrence by affecting myeloid cell activity. ABSTRACT Early recurrence remains a major challenge in the management of hepatocellular carcinoma (HCC), yet its molecular mechanisms are not fully understood.
Zhenyao Tan, Yezhen Tang, Bendong Chen, Yongxue Lv, Bozhi Zhang, Kejun Liu, Yang Bu   +6 more
wiley   +1 more source

Extracellular DNA and Deoxyribonuclease Activity as Prognostic Markers in Sepsis

Biomedicines
Background/Objectives: Sepsis is characterized by a dysregulated immune response to infection and is associated with high lethality. Extracellular DNA (ecDNA) has drawn significant interest as a damage-associated molecular pattern because of its ...
Monika Janíková, Nikola Pribulová, Katarína Kmeťová, Kristína Macáková, Anna Dobišová, Michaela Kopčová, Mária Bucová, Barbora Vlková, Peter Celec   +8 more
doaj   +1 more source

Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development

Chinese Journal of Lung Cancer, 2020
Extrachromosomal DNA (ecDNA) is a small segment of circular DNA located outside the chromosome, which has the function of self-replication. Recently, amplification of oncogenes on ecDNA has been proved to be a common phenomenon in tumor cells, and has ...
Yutong WANG, Fan YE, Xiao ZHANG, Ruihan ZOU, Mingyuan WANG, Kai YU, Shiyun CUI   +6 more
doaj   +1 more source

Effect of SARS-CoV-2 Infection and COVID-19 Vaccination on Oxidative Status of Human Placenta: A Preliminary Study

Antioxidants, 2023
Infection with SARS-CoV-2 during pregnancy increases the risk of pregnancy complications associated with inflammation, which could lead to oxidative stress in the placenta. Whether vaccination against COVID-19 has any effect is unclear.
Kristína Macáková, Petra Pšenková, Nadja Šupčíková, Barbora Vlková, Peter Celec, Jozef Záhumenský   +5 more
doaj   +1 more source

Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions

MedComm, Volume 6, Issue 12, December 2025.
Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun, Yunwei Sun, Ling Lan, Siyuan Luan, Jin Zhou, Jiehui Deng, Yong Yuan, Zhong Wu   +7 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, Volume 599, Issue 21, Page 3012-3028, November 2025.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Neutrophil extracellular traps in urinary tract infection

Frontiers in Pediatrics, 2023
BackgroundUrinary tract infections (UTI) are common types of bacterial infection in children. UTI treatment is aimed to prevent complications including hypertension, proteinuria, and progression to chronic kidney disease.
Katarína Krivošíková, Nadja Šupčíková, Alexandra Gaál Kovalčíková, Alexandra Gaál Kovalčíková, Jakub Janko, Michal Pastorek, Peter Celec, Peter Celec, Ľudmila Podracká, Ľubomíra Tóthová   +9 more
doaj   +1 more source

Untersuchung der Heterogenität extrachromosomaler zirkulärer DNA in Einzelzellen mit scEC&T-seq [PDF]

Extrachromosomal DNA circularization is a common event in cancer that can occur in various forms. Many small circular DNAs, generated through DNA fragmentation processes such as DNA damage and apoptosis, exist in both normal and cancerous tissues.
Chamorro Gonzalez, Maria del Rocio
core   +1 more source

Salivary Extracellular DNA and DNase Activity in Periodontitis

Applied Sciences, 2020
Extracellular DNA (ecDNA) is a potential marker and predictor in several inflammatory diseases. Periodontitis, a chronic inflammatory disease, is associated with epithelial cell death and could lead to release of DNA.
Barbora Konečná, Alexandra Gaál Kovalčíková, Alexandra Pančíková, Bohuslav Novák, Eva Kovaľová, Peter Celec, Ľubomíra Tóthová   +6 more
doaj   +1 more source