Results 101 to 110 of about 2,326 (226)
Clinical application of single‐cell RNA sequencing in disease and therapy
Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.This review provides a comprehensive overview of the application of scRNA‐seq in revisiting the somatic cell evolutions in human diseases, as well as in biomarker discovery and drug development. Abstract Background The emergence of single‐cell RNA sequencing (scRNA‐seq) technology has revolutionized our capacity to study cell functions in complex ...
Aisha Shigna Nadukkandy +3 more
wiley +1 more source
Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis [PDF]
, 2015 Background & aims: Inflammation is a common event in the pathogenesis of liver cirrhosis. The inflammasome pathway has acquired significant relevance in the pathogenesis of inflammation, but its role in the inflammatory response in patients with ...
Bachiller, Victoria +10 more
core +1 more source
A short artificial antimicrobial peptide shows potential to prevent or treat bone infections. [PDF]
, 2017 Infection of bone is a severe complication due to the variety of bacteria causing it, their resistance against classical antibiotics, the formation of a biofilm and the difficulty to eradicate it.
Bormann, N +7 more
core +2 more sources
Extrachromosomal Circular DNA as a Cancer Biomarker: From Diagnosis to Treatment
Cancer Innovation, Volume 4, Issue 5, October 2025.Extrachromosomal circular DNA (eccDNA) is an emerging class of genetic material that exists outside the chromosomal genome. These circular DNA molecules are gaining increasing attention as important biomarkers in cancer research due to their roles in gene amplification, genetic heterogeneity, and drug resistance.
Hexin Li +3 more
wiley +1 more source
Extrachromosomal circular DNA expressing miRNA promotes ovarian cancer progression
Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.This study revealed a 13‐fold increase in eccDNA in HGSOC compared to normal tissues, with significant enrichment in promoter and coding regions. eccDNA‐derived miRNAs (eccMIRs) were shown to enhance cancer cell proliferation, invasion and tumour growth through the expression of oncogenic miRNA sequences. The study highlights the importance of the MMEJ
Ning Wu +9 more
wiley +1 more source
Neoplasia: An International Journal for Oncology ResearchThe study of extrachromosomal DNA (ecDNA), an element existing beyond classical chromosomes, contributes to creating a more comprehensive map of the cancer genome.
Hao Zhang +8 more
doaj +1 more source
CytoCellDB: a comprehensive resource for exploring extrachromosomal DNA in cancer cell lines [PDF]
Recently, the cancer community has gained a heightened awareness of the roles of extrachromosomal DNA (ecDNA) in cancer proliferation, drug resistance and epigenetic remodeling. However, a hindrance to studying ecDNA is the lack of available cancer model
Brunk, Elizabeth +12 more
core +2 more sources
Extracellular DNA contributes to cholesterol crystal embolism-induced clot formation, acute kidney injury, and tissue infarction [PDF]
, 2021 Atherosklerose ist weltweit eine der Hauptursachen für Morbidität und Mortalität. Bei fortgeschrittener Atherosklerose ist die Cholesterinkristallembolie (CCE) eine potenziell lebensbedrohliche Komplikation mit einer durchschnittlichen Mortalität von 62 ...
Shi, Chongxu
core
, 2020 The deficits of mammography and the potential of noninvasive diagnostic testing using circulating miRNA profiles are presented in our first review article. Exosomes are important in the transfer of genetic information.
Nagy, Bálint
core +1 more source
iLABMED, Volume 3, Issue 3, Page 246-257, September 2025.Extrachromosomal circular DNA (eccDNA) has quite recently turned out to be a cardinal component in cardiovascular diseases (CVD), governing the gene expression and mechanisms of disease causation. Studies indicated an upregulation of eccDNA in pulmonary arterial hypertension (PAH), which makes it strikingly potential as a sensitive and specific ...
Saim Mahmood Khan +6 more
wiley +1 more source