Results 101 to 110 of about 2,028 (216)
3D chromatin architecture and transcription regulation in cancer [PDF]
, 2022 Chromatin has distinct three-dimensional (3D) architectures important in key biological processes, such as cell cycle, replication, differentiation, and transcription regulation.
Deng, Siwei +2 more
core +2 more sources
Scientifica, Volume 2025, Issue 1, 2025.Methotrexate (MTX), a potent analogue and antagonist of folic acid, is a first‐line treatment for rheumatoid arthritis, IBD and cancer. The development of MTX resistance contributes to the reduced efficacy and development of adverse reactions, forcing clinicians to withdraw treatment early.
Muhsina Kakkadath +4 more
wiley +1 more source
Nature Communications, 2021 The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations
Xue-Ke Zhao +18 more
doaj +1 more source
Becoming a selfish clan : recombination associated to reverse - transcription in LTR retrotransposons [PDF]
, 2019 Drost, Hajk Georg. University of Cambridge. The Sainsbury Laboratory. United Kingdom.Sánchez, Diego H. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura (IFEVA).
Drost, Hajk Georg, Sánchez, Diego H.
core +2 more sources
Potential Use of Extracellular Vesicles for the HER2 Status Assessment in Breast Cancer Patients
Genes, Chromosomes and Cancer, Volume 63, Issue 10, October 2024.ABSTRACT Human epithelial growth factor receptor 2 (HER2)‐targeted therapies are effective in patients with HER2‐positive breast cancer. Recent advances have shown that HER2‐targeted therapies can also be of benefit when treating tumors expressing low levels of HER2, highlighting the importance of identifying the HER2‐low subgroup.
Sol Moon +7 more
wiley +1 more source
Untersuchung der Heterogenität extrachromosomaler zirkulärer DNA in Einzelzellen mit scEC&T-seq [PDF]
Extrachromosomal DNA circularization is a common event in cancer that can occur in various forms. Many small circular DNAs, generated through DNA fragmentation processes such as DNA damage and apoptosis, exist in both normal and cancerous tissues.
Chamorro Gonzalez, Maria del Rocio
core +1 more source
Prognostic value of various subtypes of extracellular DNA in ovarian cancer patients
Journal of Ovarian Research, 2018 Background Patients with ovarian cancer represent a heterogeneous population with a variable prognosis and response to chemotherapy. Plasma DNA has been shown to have a prognostic value in different types of cancer including ovarian carcinoma.
Katarina Kalavska +9 more
doaj +1 more source
The multifaceted functions of DNA‐PKcs: implications for the therapy of human diseases
MedComm, Volume 5, Issue 7, July 2024.DNA‐PKcs is involved in nervous system diseases, senescence, asthma, cardiovascular disease, cancers, chronic kidney diseases, and rheumatoid arthritis. Abstract The DNA‐dependent protein kinase (DNA‐PK), catalytic subunit, also known as DNA‐PKcs, is complexed with the heterodimer Ku70/Ku80 to form DNA‐PK holoenzyme, which is well recognized as ...
Jinghong Wu +6 more
wiley +1 more source
, 2020 The deficits of mammography and the potential of noninvasive diagnostic testing using circulating miRNA profiles are presented in our first review article. Exosomes are important in the transfer of genetic information.
Nagy, Bálint
core +1 more source
Population dynamics of multiple ecDNA types
38 pages, 6 main figures, 6 supplementary ...
Scanu, Elisa +2 more
openaire +2 more sources