Results 111 to 120 of about 2,028 (216)

Biological Mechanisms of Gold Nanoparticle Radiosenstitisation [PDF]

, 2017
There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties that make them ideal candidates as ...
Butterworth, Karl T., Connolly, Chris, Prise, Kevin M., Rosa, Soraia, Schettino, Giuseppe   +4 more
core   +1 more source

Machine learning-based extrachromosomal DNA identification in large-scale cohorts reveals its clinical implications in cancer

Nature Communications
The clinical implications of extrachromosomal DNA (ecDNA) in cancer therapy remain largely elusive. Here, we present a comprehensive analysis of ecDNA amplification spectra and their association with clinical and molecular features in multiple cohorts ...
Shixiang Wang, Chen-Yi Wu, Ming-Ming He, Jia-Xin Yong, Yan-Xing Chen, Li-Mei Qian, Jin-Ling Zhang, Zhao-Lei Zeng, Rui-Hua Xu, Feng Wang, Qi Zhao   +10 more
doaj   +1 more source

Cis‐regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers

Molecular Oncology, Volume 18, Issue 5, Page 1189-1208, May 2024.
We show that human papillomavirus (HPV) integrations in cervical cancers alter host 3D chromatin contacts and cause over‐expression of genes (including MYC, TP63 and ERBB2), which are mostly confined within the topologically associating domains with integration.
Anurag Kumar Singh, Kaivalya Walavalkar, Daniele Tavernari, Giovanni Ciriello, Dimple Notani, Radhakrishnan Sabarinathan   +5 more
wiley   +1 more source

Identification and characterization of extrachromosomal circular DNA in large‐artery atherosclerotic stroke

Journal of Cellular and Molecular Medicine, Volume 28, Issue 7, April 2024.
Abstract Extrachromosomal circular DNA (eccDNA) is a new biomarker and regulator of diseases. However, the role of eccDNAs in large‐artery atherosclerotic (LAA) stroke remains unclear. Through high‐throughput circle‐sequencing technique, the length distribution, genomic characteristic and motifs feature of plasma eccDNA from healthy controls (CON) and ...
Kejie Chen, Yanqi Chi, Hang Cheng, Min Yang, Quandan Tan, Junli Hao, Yapeng Lin, Fengkai Mao, Song He, Jie Yang   +9 more
wiley   +1 more source

Pre-Analytical Factors Affecting Extracellular DNA in Saliva

Diagnostics
Salivary DNA is widely used for genetic analyses because of its easy collection. However, its extracellular fraction in particular, similar to the extracellular DNA (ecDNA) in plasma, could be a promising biomarker for oral or systemic diseases.
Ľubica Janovičová, Dominika Holániová, Barbora Vlková, Peter Celec   +3 more
doaj   +1 more source

Advances in sequencing-based studies of microDNA and ecDNA: Databases, identification methods, and integration with single-cell analysis

Computational and Structural Biotechnology Journal, 2023
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from genomic DNA but are separate from chromosomes. They are common in various organisms, with sizes ranging from a few hundred to millions of base pairs.
Rong Jiang, Manqiu Yang, Shufan Zhang, Moli Huang   +3 more
doaj  

Characterisation of meropenem‐resistant Bacillus sp. FW 1 isolated from biogas digestate

Environmental Microbiology Reports, Volume 16, Issue 1, February 2024.
The novel resistance of Heyndrickxia oleronia (formerly known as Bacillus oleronius) FW 1 to meropenem is suggested to arise from the production of unclassified carbapenemase, or an overexpression of metallo‐β‐lactamase. It is suggested that the meropenem resistance observed in strain FW 1 is not transferable. Abstract Recently a Bacillus sp. strain FW
He Sun, Jolanta J. Levenfors, Christian Brandt, Anna Schnürer   +3 more
wiley   +1 more source

Extracellular vesicle‐encapsulated microRNA‐296‐3p from cancer‐associated fibroblasts promotes ovarian cancer development through regulation of the PTEN/AKT and SOCS6/STAT3 pathways

Cancer Science, Volume 115, Issue 1, Page 155-169, January 2024.
Abstract Cancer‐associated fibroblasts (CAFs), as important components of the tumor microenvironment, can regulate intercellular communication and tumor development by secreting extracellular vesicles (EVs). However, the role of CAF‐derived EVs in ovarian cancer has not been fully elucidated.
Luyao Sun, Miaola Ke, Mengyuan Yin, Ying Zeng, Yutong Ji, Yiming Hu, Songbin Fu, Chunyu Zhang   +7 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

Cells, 2020
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to an adaptive immune response in the host and the formation of anti-SARS-CoV-2 specific antibodies.
Léonie A. N. Staats, Hella Pfeiffer, Jasmin Knopf, Aylin Lindemann, Julia Fürst, Andreas E. Kremer, Holger Hackstein, Markus F. Neurath, Luis E. Muñoz, Susanne Achenbach, Moritz Leppkes, Martin Herrmann, Georg Schett, Ulrike Steffen   +13 more
doaj   +1 more source