Results 111 to 120 of about 2,326 (226)

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers [PDF]

, 2021
Joshua T. Lange, Celine Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L. Hung, Kathryn E. Yost, Quanming Shi, Marcella L. Erb, Utkrisht Rajkumar, Sihan Wu, Charles Swanton, Zhe Liu, Weini Huang, Howard Y. Chang, Vineet Bafna, Anton G. Henssen, Benjamin Werner, Paul S. Mischel   +18 more
openalex   +1 more source

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 6, June 2025.
ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Jiajia Li, Peng Luo, Zhengrui Li, Qi Wang, Xufeng Huang, Keliang Wang, Ruo Wang, Runzhi Chen   +7 more
wiley   +1 more source

Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses

Frontiers in Pharmacology
IntroductionTraditional drug discovery efforts primarily target rapid, reversible protein-mediated adaptations to counteract cancer cell resistance. However, cancer cells also utilize DNA-based strategies, often perceived as slow, irreversible changes ...
Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk   +18 more
doaj   +1 more source

Becoming a selfish clan : recombination associated to reverse - transcription in LTR retrotransposons [PDF]

, 2019
Drost, Hajk Georg. University of Cambridge. The Sainsbury Laboratory. United Kingdom.Sánchez, Diego H. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura (IFEVA).
Drost, Hajk Georg, Sánchez, Diego H.
core   +2 more sources

Cancer: From a Genetic Disorder to a Systemic Disease

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Ada Hang‐Heng Wong, Yuming Hu
wiley   +1 more source

Environmental Drivers of Malignant Clonal Selection in Precancerous Lesion Evolution

Cell Proliferation, Volume 58, Issue 5, May 2025.
ABSTRACT Somatic mutations accumulation and subsequent malignant clonal selection are the processes that lead to cancer. The intricacy includes exposure to carcinogens as well as the ways in which these exposures interact with genetic, polygenic, or epigenetic predispositions.
Yancheng Lai, Shaosen Zhang
wiley   +1 more source

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity

Cell Reports
Summary: Neuroblastoma exhibits significant inter- and intra-tumor genetic heterogeneity and varying clinical outcomes. Extrachromosomal DNAs (ecDNAs) may drive this heterogeneity by independently segregating during cell division, leading to rapid ...
Maja C. Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H. Schulte, Richard P. Koche, Anton G. Henssen, Roland F. Schwarz, Kerstin Haase   +11 more
doaj   +1 more source

CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing. [PDF]

Extrachromosomal DNA (ecDNA) is a central mechanism for focal oncogene amplification in cancer, occurring in ∼15% of early-stage cancers and ∼30% of late-stage cancers.
Bafna, Vineet, Bu, Xinxin, Chang, Howard, Hung, King, Jones, Matthew, Luebeck, Jens, Mischel, Paul, Wong, Ivy, Yi, Hyerim, Zhang, Shu, Zhu, Kaiyuan   +10 more
core   +1 more source

Landscape of extrachromosomal DNA characteristics in high-grade serous ovarian cancer via long-read sequencing

Cell Reports
Summary: The non-Mendelian inheritance of extrachromosomal DNA (ecDNA) exacerbates tumor genomic heterogeneity and evolution. Due to short-read sequencing’s reconstruction deficiencies, ecDNA abundance in clinical tumor tissues requires further ...
Ruoming Sun, Zongkai Li, Yi Liu, Yanbing Hou, Bowen Zhao, Chunpeng Chen, Jingwen Fang, Chuang Guo, Ying Zhou, Kun Qu, Shouzhen Li   +10 more
doaj   +1 more source