Results 121 to 130 of about 2,326 (226)

Machine learning-based extrachromosomal DNA identification in large-scale cohorts reveals its clinical implications in cancer

Nature Communications
The clinical implications of extrachromosomal DNA (ecDNA) in cancer therapy remain largely elusive. Here, we present a comprehensive analysis of ecDNA amplification spectra and their association with clinical and molecular features in multiple cohorts ...
Shixiang Wang, Chen-Yi Wu, Ming-Ming He, Jia-Xin Yong, Yan-Xing Chen, Li-Mei Qian, Jin-Ling Zhang, Zhao-Lei Zeng, Rui-Hua Xu, Feng Wang, Qi Zhao   +10 more
doaj   +1 more source

Prognostic value of various subtypes of extracellular DNA in ovarian cancer patients

Journal of Ovarian Research, 2018
Background Patients with ovarian cancer represent a heterogeneous population with a variable prognosis and response to chemotherapy. Plasma DNA has been shown to have a prognostic value in different types of cancer including ovarian carcinoma.
Katarina Kalavska, Tomas Minarik, Barbora Vlkova, Denisa Manasova, Michaela Kubickova, Andrej Jurik, Jozef Mardiak, Jozef Sufliarsky, Peter Celec, Michal Mego   +9 more
doaj   +1 more source

Does inappropriate DNA replication provide a mechanism for the de novo acquisition of drug resistance? [PDF]

EGFR is the most common driver mutation in non-small cell lung cancer (NSCLC) and is a common drug target across several cancers. Targeted therapeutics such as those that target EGFR (e.g.

core   +2 more sources

Pre-Analytical Factors Affecting Extracellular DNA in Saliva

Diagnostics
Salivary DNA is widely used for genetic analyses because of its easy collection. However, its extracellular fraction in particular, similar to the extracellular DNA (ecDNA) in plasma, could be a promising biomarker for oral or systemic diseases.
Ľubica Janovičová, Dominika Holániová, Barbora Vlková, Peter Celec   +3 more
doaj   +1 more source

ecDNA machine learning modeling

, 2023
Shixiang Wang, Qi Zhao
openalex   +2 more sources

pengweixing/ecDNA-on-GCA: ecDNA_detection_on_GCA

, 2021
pengweixing
openalex   +2 more sources

Search [PDF]

, 2021
https://mouseion.jax.org/search/1037/thumbnail ...
The Jackson Laboratory
core   +1 more source

A standardized protocol for sample preparation for scanning electron microscopy to visualize extrachromosomal DNA

BioTechniques
Extrachromosomal DNA (ecDNA) are circular DNA structures associated with cancer and drug resistance. One specific type, double minute (DM) chromosomes, has been studied since the 1960s using imaging techniques like cytogenetics and fluorescence ...
Jillann A. Madren, Jingting Chen, William Dennis, Christina Ford, Kristen K. White, Elizabeth Brunk   +5 more
doaj   +1 more source

EPCO-14. MULTIFACETED TRANSCRIPTOMIC AND PROTEOMIC ANALYSES IDENTIFIED PUTATIVE ALTERNATIVE SPLICING-DERIVED CELL SURFACE ANTIGENS IN GLIOMA [PDF]

, 2021
BACKGROUND To develop effective immunotherapy for gliomas, it is crucial to expand the repertoire of targetable antigens. Recent studies have suggested that alternative splicing (AS), or its deriving tumor-specific junctions (“neojunctions”), could ...
Costello, Joseph, Diaz, Aaron, Diebold, David, Driks, Hannah, Kwok, Darwin, Leung, Kevin, Nejo, Takahide, Okada, Hideho, Wang, Albert, Wang, Lin, Watchmaker, Payal, Wells, Jim   +11 more
core  

Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis

Journal of Inflammation
Background Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequence of the inflammation, but the ecDNA could also be involved in the unknown etiopathogenesis of RA.
Kristína Macáková, Veronika Borbélyová, Mária Tekeľová, Jakub Janko, Michal Pastorek, Richard Hokša, Norbert Moravanský, Emöke Šteňová, Barbora Vlková, Peter Celec   +9 more
doaj   +1 more source