Results 141 to 150 of about 2,326 (226)

Extrachromosomal DNA : New Players in Oncology

Asian Journal of Medical Sciences
DNA that is found outside the main chromosomes in a cell's nucleus is known as extrachromosomal DNA. This type of DNA is not part of the standard 23 pairs of chromosomes in humans and instead exists as standalone circular or linear DNA structures. Unlike
Ruby Dhar , Arun Kumar , Subhradip Karmakar   +2 more
doaj   +1 more source

Ανίχνευση ομαδοποιημένων οξειδωτικών βλαβών DNA σε συστημικό επίπεδο ύστερα από έκθεση σε ιοντίζουσα ακτινοβολία [PDF]

, 2016
Kotsaris, Vasilis, Κότσαρης, Βασίλης   +1 more
core   +1 more source

Transcription Machinery Anchors ecDNAs to Mitotic Chromosomes for Segregation

AbstractExtrachromosomal DNA (ecDNA) is a prevalent driver of cancer, whose random segregation promotes aggressive tumors. Acentric ecDNAs attach to chromosomes during mitosis for segregation. However, the molecular mechanism governing ecDNA-chromosome mitotic interactions remains poorly understood.
Yipeng Xie, Jun Yi Stanley Lim, Wenyue Liu, Collin Gilbreath, Yoon Jung Kim, Sihan Wu   +5 more
openaire   +1 more source

3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression

Nature Communications
Cancer genomes are composed of many complex structural alterations on chromosomes and extrachromosomal DNA (ecDNA), making it difficult to identify non-coding enhancer regions that are hijacked to activate oncogene expression.
Katelyn L. Mortenson, Courtney Dawes, Emily R. Wilson, Nathan E. Patchen, Hailey E. Johnson, Jason Gertz, Swneke D. Bailey, Yang Liu, Katherine E. Varley, Xiaoyang Zhang   +9 more
doaj   +1 more source

Leveraging AI to Automate Detection and Quantification of Extrachromosomal DNA (ecDNA) to Decode Drug Responses [PDF]

Kohen Goble, Aarav Mehta, Damien Guilbaud, J H Fessler, Jingting Chen, William Nenad, Oliver Cope, David Cheng, William C. Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk   +12 more
openalex   +1 more source

Reviewer #1 (Public Review): Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors

, 2023
Lin Shen, Jo Se-Young, Luebeck Jens, Chang Howard Y., Sihan Wu, Mischel Paul S., Bafna Vineet   +6 more
openalex   +1 more source

Comprehensive profiling of extrachromosomal circular DNAs in colorectal cancer progression

Scientific Reports
Colorectal cancer (CRC) development involves a series of molecular events that drive the progression from normal colorectal epithelium to adenoma and eventually to invasive carcinoma.
Lu Lu, Mingjie Chen, Guicheng Zhang, Yujing Liu, Xiangyuan Xu, Zenghua Jiang, Yangxian Xu, Tao Liu, Fan Yang, Guang Ji, Hanchen Xu   +10 more
doaj   +1 more source

78P Exploring ecDNA heterogeneity and evolution in non-small cell lung cancer [PDF]

J. Kittel, Chris Bailey, Oriol Pich, Kerstin Thol, C. Lombardelli, N. Sharma, Georgia Stavrou, Nnennaya Kanu, Mariam Jamal‐Hanjani, Charles Swanton   +9 more
openalex   +1 more source

Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA [PDF]

, 2021
Erik N. Bergstrom, Jens Luebeck, Mia Petljak, Vineet Bafna, Paul S. Mischel, Reuben S. Harris, Ludmil B. Alexandrov   +6 more
openalex   +1 more source

Deciphering of ecDNA using Whole Genome Sequencing data from gastric cancer

, 2020
Yuvarani Masarapu
openalex   +1 more source