Results 181 to 190 of about 2,028 (216)

Reviewer #1 (Public Review): Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors

Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang, Sihan Wu, Paul S. Mischel, Vineet Bafna   +6 more
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Unified molecular approach for spatial epigenome, transcriptome, and cell lineages. [PDF]

Proc Natl Acad Sci U S A
Huang YH, Belk JA, Zhang R, Weiser NE, Chiang Z, Jones MG, Mischel PS, Buenrostro JD, Chang HY.   +8 more
europepmc   +1 more source

Macrophage Polarization in Heterotopic Ossification: Inflammation, Osteogenesis, and Emerging Therapeutic Targets. [PDF]

Int J Mol Sci
Ren Y, Zhao W, Liu M, Lin H.
europepmc   +1 more source

Extracellular DNA, hyaluronic acid, HIF pathways, and LncRNAs as predictive biomarkers of severe COVID-19. [PDF]

Virol J
Dubrovskyi E, Drevytska T, Portnychenko A, Dosenko V, Halabitska I, Petakh P, Kainov DE, Kamyshnyi O.   +7 more
europepmc   +1 more source

Engineered extrachromosomal oncogene amplifications promote tumorigenesis. [PDF]

Nature
Pradella D, Zhang M, Gao R, Yao MA, Gluchowska KM, Cendon-Florez Y, Mishra T, La Rocca G, Weigl M, Jiao Z, Nguyen HHM, Lisi M, Ozimek MM, Mastroleo C, Chen K, Grimm F, Luebeck J, Zhang S, Zolli AA, Sun EG, Dameracharla B, Zhao Z, Pritykin Y, Sigel C, Chang HY, Mischel PS, Bafna V, Antonescu CR, Ventura A.   +28 more
europepmc   +1 more source

The maintenance and de-mixing of extrachromosomal DNA variants in single cells

Scanu E, Werner B, Huang W.
europepmc   +1 more source

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Methods, bioinformatics tools and databases in ecDNA research: An overview

Computers in Biology and Medicine, 2023
Extrachromosomal DNA (ecDNA), derived from chromosomes, is a cancer-specific circular DNA molecule. EcDNA drives tumor initiation and progression, which is associated with poor clinical outcomes and drug resistance in a wide range of cancers. Although ecDNA was first discovered in 1965, tremendous technological revolutions in recent years have provided
Xinyu Zhao, Huan Zhao, Yupeng Liu, Zhiyun Guo   +3 more
semanticscholar   +3 more sources

Abstract 1612: Timing ecDNA acquisition across cancer

Cancer Research
Extrachromosomal DNA (ecDNA) are acentric, circular DNA fragments which form after DNA double strand breaks. They segregate randomly during mitosis, promoting high-level amplifications of positively selected oncogenes such as EGFR and MYC.
Andrew R. Lynch, P. Van Loo
semanticscholar   +2 more sources

ecDNAs personify cancer gangsters

Molecular Cell, 2022
Alterations to gene regulatory plexuses typify oncogenesis, and two recent studies from Hung, Yost, Xie et al. (Hung et al., 2021) and Yi et al. (2021) collectively reveal the competitive advantage of extrachromosomal DNAs (ecDNAs) to set their own rules to control transcription by clustering into ecDNA hubs through intermolecular interactions that ...
Tina, Keshavarzian, Mathieu, Lupien
openaire   +2 more sources