Results 181 to 190 of about 2,326 (226)

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors. [PDF]

Nat Commun
Launspach M, Macos J, Afzal S, Hohmann J, Appis ML, Pilgram M, Beez S, Ohlendorf E, van der Ven CFT, Lachiheb C, Töws K, Andersch L, Jens M, Zirngibl F, Kath J, Stecklum M, Rodriguez-Fos E, Anders K, Wagner DL, Henssen AG, Kühn R, Eggert A, Künkele A.   +22 more
europepmc   +1 more source

A novel CRISPR-Cas9 nickase-mediated rolling circle amplification (CRIRCA) technique for gene identification and quantitative analysis of extrachromosomal DNA. [PDF]

J Adv Res
Song Y, Guan C, Zhang Y, Xu Y, Li P, Luo L, Feng C, Chen G.   +7 more
europepmc   +1 more source

EcDNA-borne structural variants drive oncogenic fusion transcript amplification

Hyerim Yi, Shu Zhang, Jason Swinderman, Yanbo Wang, Vishnupriya Kanakaveti, King L. Hung, Ivy Tsz-Lo Wong, Suhas Srinivasan, Ellis J. Curtis, Aarohi Bhargava-Shah, Rui Li, Matthew G. Jones, Jens Luebeck, Chris Bailey, Y. Zhao, Julia A. Belk, Katerina Kraft, Quanming Shi, Xiaowei Yan, Simon K. Pritchard, Kabir S. Mahajan, Fei Liang, Mariam Jamal‐Hanjani, Dean W. Felsher, Luke A. Gilbert, Vineet Bafna, Paul S. Mischel, H J Chang   +27 more
openalex   +1 more source

Whole genome sequencing revealed esophageal squamous cell carcinoma related biomarkers. [PDF]

PLoS One
Li M, Li L, Wang X, Zhao Y, Du P, Wang W, Wang Z, Wang Y, Sheng Y, Gu M, Jia X.   +10 more
europepmc   +1 more source

BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance

bioRxiv
Extrachromosomal circular DNA (ecDNA) are commonly produced within the nucleus to drive genome dynamics and heterogeneity, enabling cancer cell evolution and adaptation. However, the mechanisms underlying ecDNA biogenesis remain poorly understood.
Oliver W. Chung, Shun Yao, Fu Yang, Ling Wang, Christian G. Cerda-Smith, Haley M. Hutchinson, Kris C. Wood, Weijia Su, M. Khasraw, Lee Zou, Dale A. Ramsden, Z. Zhang   +11 more
semanticscholar   +3 more sources

Safeguarding spermatogenesis from retrotransposon insertions by forming ecDNA

bioRxiv
Retrotransposon mobilization in germline cells enables the rewriting of genetic information to drive genome innovation, species evolution, and adaptation through the generation of de novo mutations. However, uncontrolled mobilization can cause DNA breaks
Lauren Tracy, Z. Zhang
semanticscholar   +2 more sources

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Abstract 3897: Investigating the prevalence of ecDNA in breast cancer

Cancer Research
Extrachromosomal DNA (ecDNA) has been described in multiple cancer types. ecDNAs are circular and are usually greater than 500 base pairs in size. ecDNA structures lack centromeres and thus do not follow the Mendelian mode of inheritance, segregating ...
Georgia Stavrou, Chris Bailey, Jeanette Kittel, M. Jamal-Hanjani, C. Swanton, N. Kanu   +5 more
semanticscholar   +2 more sources

Mitotic transcription ensures ecDNA inheritance through chromosomal tethering

bioRxiv
SUMMARYExtrachromosomal DNA (ecDNA) are circular DNA bodies that play critical roles in tumor progression and treatment resistance by amplifying oncogenes across a wide range of cancer types. ecDNA lack centromeres and are thus not constrained by typical Mendelian segregation, enabling their unequal accumulation within daughter cells and associated ...
Ashley Nichols, R. Norman, Yanyang Chen, Yujin Choi, Josefine Striepen, Eralda Salataj, Eléonore Toufektchan, R. Koche, J. Maciejowski   +8 more
semanticscholar   +3 more sources

ecDNAs personify cancer gangsters

Molecular Cell, 2022
Alterations to gene regulatory plexuses typify oncogenesis, and two recent studies from Hung, Yost, Xie et al. (Hung et al., 2021) and Yi et al. (2021) collectively reveal the competitive advantage of extrachromosomal DNAs (ecDNAs) to set their own rules to control transcription by clustering into ecDNA hubs through intermolecular interactions that ...
Tina, Keshavarzian, Mathieu, Lupien
openaire   +2 more sources

Extrachromosomal DNA (ecDNA) in cancer pathogenesis

Current Opinion in Genetics & Development, 2021
In cancer, oncogenes and surrounding regulatory regions can untether themselves from chromosomes, forming extrachromosomal DNA particles (ecDNAs). Because of their non-chromosomal inheritance, ecDNA drives high oncogene copy number and intratumoral genetic heterogeneity, endowing tumors with the ability to rapidly change their genomes, accelerating ...
Sihan Wu, Vineet Bafna, Paul S Mischel
openaire   +2 more sources