Results 11 to 20 of about 2,028 (216)

Insight on ecDNA-mediated tumorigenesis and drug resistance [PDF]

Heliyon
Extrachromosomal DNAs (ecDNAs) are a pervasive feature found in cancer and contain oncogenes and their corresponding regulatory elements. Their unique structural properties allow a rapid amplification of oncogenes and alter chromatin accessibility ...
Qing Huang, Su Zhang, Guosong Wang, Junhong Han   +3 more
doaj   +5 more sources

Extrachromosomal DNA (ecDNA) in cancer: mechanisms, functions, and clinical implications

Frontiers in Oncology, 2023
Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the development and heterogeneity of cancer. The rapid evolution of methods to detect ecDNA, including microscopic and sequencing approaches, has greatly enhanced our knowledge ...
Yucheng Dong, Qi He, Xinyu Chen, Fan Yang, Li He, Yongchang Zheng   +5 more
doaj   +4 more sources

Enhancing transcription-replication conflict targets ecDNA-positive cancers. [PDF]

Nature
Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. ecDNA renders tumours treatment resistant by facilitating massive oncogene transcription and rapid genome evolution, contributing to poor patient survival1–7.
Tang J, Weiser NE, Wang G, Chowdhry S, Curtis EJ, Zhao Y, Wong IT, Marinov GK, Li R, Hanoian P, Tse E, Mojica SG, Hansen R, Plum J, Steffy A, Milutinovic S, Meyer ST, Luebeck J, Wang Y, Zhang S, Altemose N, Curtis C, Greenleaf WJ, Bafna V, Benkovic SJ, Pinkerton AB, Kasibhatla S, Hassig CA, Mischel PS, Chang HY.   +29 more
europepmc   +6 more sources

Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA [PDF]

Nature, 2022
Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions1–5, diffuse hypermutation termed omikli6, and longer strand ...
Erik N. Bergstrom, Jens Luebeck, Mia Petljak, Azhar Khandekar, Mark Barnes, Tongwu Zhang, Christopher D. Steele, Nischalan Pillay, Maria Teresa Landi, Vineet Bafna, Paul S. Mischel, Reuben S. Harris, Ludmil B. Alexandrov   +12 more
semanticscholar   +10 more sources

Imaging extrachromosomal DNA (ecDNA) in cancer [PDF]

Histochemistry and Cell Biology
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of oncogene amplification, and correlate with treatment resistance and poor prognosis. Consequently, there is great interest in exploring
Karin Purshouse, Steven M Pollard, Wendy A. Bickmore   +2 more
semanticscholar   +5 more sources

Oncogene Silencing via ecDNA Micronucleation

bioRxiv
AbstractExtrachromosomal DNA (ecDNA) is a common source of oncogene amplification across many types of cancer. The non-Mendelian inheritance of ecDNA contributes to heterogeneous tumour genomes that rapidly evolve to resist treatment. Here, using single-cell and live-cell imaging, single-micronucleus sequencing, and computational modelling, we ...
Brückner L, Xu R, Tang J, Herrmann A, Wong IT, Zhang S, Tu F, Pilon M, Kukalev A, Pardon K, Sidorova O, Atta J, Yu Q, Pradella D, Ilić M, Novais-Cruz M, Kaltenbach S, Treue D, Giurgiu M, Herzog S, Hollinger A, Fernandez M, Becker F, Louma V, Schmargon R, Dörr J, Gamlin D, Lehmann A, Gürgen D, Richter M, Dubois F, Simeoni F, Pennycook BR, Hamilton A, Lindemann RK, Fischer M, Bafna V, Wahl G, Koche RP, Chang HY, Papathanasiou S, Medema R, Spanjaard B, Ventura A, Pombo A, Huang W, Werner B, Mischel PS, Henssen AG.   +48 more
europepmc   +5 more sources

Breakage fusion bridge cycles drive high oncogene number with moderate intratumoural heterogeneity [PDF]

Nature Communications
Oncogene amplification is a key driver of cancer pathogenesis. Both breakage fusion bridge (BFB) cycles and extrachromosomal DNA (ecDNA) can lead to high oncogene copy numbers, but the impact of BFB amplifications on intratumoral heterogeneity, treatment
Siavash Raeisi Dehkordi, Ivy Tsz-Lo Wong, Jing Ni, Jens Luebeck, Kaiyuan Zhu, Gino Prasad, Lena Krockenberger, Guanghui Xu, Biswanath Chowdhury, Utkrisht Rajkumar, Ann Caplin, Daniel Muliaditan, Aditi Gnanasekar, Ceyda Coruh, Qiushi Jin, Kristen Turner, Shu Xian Teo, Andy Wing Chun Pang, Ludmil B. Alexandrov, Christelle En Lin Chua, Frank B. Furnari, John Maciejowski, Thomas G. Paulson, Julie A. Law, Howard Y. Chang, Feng Yue, Ramanuj DasGupta, Jean Zhao, Paul S. Mischel, Vineet Bafna   +29 more
doaj   +4 more sources

MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. [PDF]

Nature
Intratumour heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance1,2. Oncogene dosage variation contributes to cell-state transitions and phenotypic heterogeneity3, thereby providing a substrate for somatic evolution.
Fiorini E, Malinova A, Schreyer D, Pasini D, Bevere M, Alessio G, Rosa D, D'Agosto S, Azzolin L, Milite S, Andreani S, Lupo F, Veghini L, Grimaldi S, Pedron S, Castellucci M, Nourse C, Salvia R, Malleo G, Ruzzenente A, Guglielmi A, Milella M, Lawlor RT, Luchini C, Agostini A, Carbone C, Pilarsky C, Sottoriva A, Scarpa A, Tuveson DA, Bailey P, Corbo V.   +31 more
europepmc   +5 more sources

The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution

Nature
Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogeneity1. In this study, we investigated the evolution of genomic signatures caused by endogenous and external mutagenic processes and their interplay with ...
Duy Nguyen, William F. Hooper, Weisi Liu, Timothy R. Chu, Heather Geiger, Jennifer Shelton, Minita Shah, Zoe R. Goldstein, Lara Winterkorn, Adrienne Helland, Michael Sigouros, Jyothi Manohar, Jenna E. Moyer, Majd Al Assaad, Alissa Semaan, Sandra Cohen, Florencia P. Madorsky Rowdo, David Wilkes, Mohamed Osman, Rahul Singh, Andrea Sboner, Henkel Valentine, Philip H. Abbosh, Scott T. Tagawa, David M. Nanus, Jones T. Nauseef, Cora N. Sternberg, Ana M. Molina, Douglas S. Scherr, Giorgio Inghirami, Juan Miguel Mosquera, Olivier Elemento, Nicolas Robine, Bishoy M. Faltas   +33 more
semanticscholar   +5 more sources

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells [PDF]

eLife, 2022
Extrachromosomal DNA (ecDNA) are frequently observed in human cancers and are responsible for high levels of oncogene expression. In glioblastoma (GBM), ecDNA copy number correlates with poor prognosis.
Karin Purshouse, Elias T Friman, Shelagh Boyle, Pooran Singh Dewari, Vivien Grant, Alhafidz Hamdan, Gillian M Morrison, Paul M Brennan, Sjoerd V Beentjes, Steven M Pollard, Wendy A Bickmore   +10 more
doaj   +3 more sources