Results 11 to 20 of about 2,326 (226)

Unfolding ecDNA as a pan-cancer therapeutic target [PDF]

Medical Review
Extrachromosomal DNA (ecDNA) drives the evolution of cancer cells. Its widespread presence in tumors and strong association with poor clinical outcomes make ecDNA a promising and broadly applicable therapeutic target. Recent studies have begun to unravel
Zhang Yang, Chen Ruirui, Gan Haiyun
doaj   +6 more sources

scCirclehunter delineates ecDNA-containing cells using single-cell ATAC-seq, with a focus on glioblastoma [PDF]

Cell Discovery
In cancer, extrachromosomal DNA (ecDNA) contributes to tumor heterogeneity and is associated with poor prognosis, but studies on patient-derived ecDNA are relatively limited at single-cell resolution.
Rong Jiang, Zhengmao Lu, Fang Li, Yibei Zhu, Manqiu Yang, Shufan Zhang, Ping Wu, Chengliang Gong, Yiyuan Fei, Yonghua Sang, Yulun Huang, Jiong Jiong Guo, Moli Huang   +12 more
doaj   +5 more sources

Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer [PDF]

Nature Communications
Extrachromosomal circular DNA (ecDNA) has been found in most types of human cancers, and ecDNA incorporating viral genomes has recently been described, specifically in human papillomavirus (HPV)-mediated oropharyngeal cancer (OPC). However, the molecular
Takuya Nakagawa, Jens Luebeck, Kaiyuan Zhu, Joshua T. Lange, Roman Sasik, Chad Phillips, Sayed Sadat, Sara Javadzadeh, Qian Yang, Abdula Monther, Santiago Fassardi, Allen Wang, Kersi Pestonjamasp, Brin Rosenthal, Kathleen M. Fisch, Paul Mischel, Vineet Bafna, Joseph A. Califano   +17 more
doaj   +6 more sources

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment [PDF]

bioRxiv
ecDNA contributes to cancer genetic heterogeneity through random segregation during mitosis. Emerging evidence links ecDNA to immune evasion, but the mechanism remains elusive. Using genetically engineered mouse models of pancreatic ductal adenocarcinoma
Qiao K, Yang Q, Li T, Chen X, Yazgan Z, Kim YJ, Gilbreath C, Stanley Lim JY, Xie Y, Sun X, Liu Y, Jia Y, Chen ZJ, Huang H, Wu S.   +14 more
europepmc   +4 more sources

ecDNA replication is disorganised and vulnerable to replication stress [PDF]

Nucleic Acids Research
Extrachromosomal DNA (ecDNA) is a critical driver of cancer progression, contributing to tumour growth, evolution, and therapeutic resistance through oncogene amplification. Despite its significance, the replication of ecDNA remains poorly understood. In
Jaworski JJ, Pfuderer PL, Czyz P, Petris G, Boemo MA, Sale JE.   +5 more
europepmc   +4 more sources

An EcDNA gene-based risk model and functional verification of a key ec-lncRNA AC016394.2 for prostate cancer [PDF]

Cancer Cell International
Background Prostate cancer(PCa) ranks among the most frequently diagnosed malignancies in men. The progression and heterogeneity of tumors pose significant challenges to clinical prognosis and treatment strategies.
JiangPing Qiu, Jiang Wu, Nan Zhou, Cong Lai, Xin Huang, Cheng Liu, XiaoQing Yuan, Kewei Xu   +7 more
doaj   +5 more sources

Enhancing transcription–replication conflict targets ecDNA-positive cancers [PDF]

Nature
Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. ecDNA renders tumours treatment resistant by facilitating massive oncogene transcription and rapid genome evolution, contributing to poor patient survival1–7.
Jun Tang, Natasha E. Weiser, Guiping Wang, Sudhir Chowdhry, Ellis J. Curtis, Yanding Zhao, Ivy Tsz-Lo Wong, Georgi K. Marinov, Rui Li, Philip Hanoian, Edison Tse, Salvador Garcia Mojica, Ryan J. Hansen, Joshua Plum, Auzon Steffy, Snezana Milutinovic, S. Todd Meyer, Jens Luebeck, Yanbo Wang, Shu Zhang, Nicolas Altemose, Christina Curtis, William J. Greenleaf, Vineet Bafna, Stephen J. Benkovic, Anthony B. Pinkerton, Shailaja Kasibhatla, Christian A. Hassig, Paul S. Mischel, Howard Y. Chang   +29 more
semanticscholar   +4 more sources

Research Advances of Extrachromosomal Circular DNA in Breast Cancer [PDF]

Cancer Medicine
Background This article presents an extensive review of the advancements in research concerning extrachromosomal circular DNA (ecDNA) within the context of breast cancer.
Xiaodan Zhu, Yiyang Qian, Quan Tang, Jiahui Li, Yuqing Geng, Shixia Gong, Chunhui Jin   +6 more
doaj   +3 more sources

ecDNA replication is disorganized and vulnerable to replication stress. [PDF]

Nucleic Acids Res
Extrachromosomal DNA (ecDNA) is a critical driver of cancer progression, contributing to tumour growth, evolution, and therapeutic resistance through oncogene amplification. Despite its significance, the replication of ecDNA remains poorly understood. In
Jaworski JJ, Pfuderer PL, Czyz P, Petris G, Boemo MA, Sale JE.   +5 more
europepmc   +4 more sources

Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA [PDF]

Nature, 2022
Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions1–5, diffuse hypermutation termed omikli6, and longer strand ...
Erik N. Bergstrom, Jens Luebeck, Mia Petljak, Azhar Khandekar, Mark Barnes, Tongwu Zhang, Christopher D. Steele, Nischalan Pillay, Maria Teresa Landi, Vineet Bafna, Paul S. Mischel, Reuben S. Harris, Ludmil B. Alexandrov   +12 more
core   +9 more sources