Results 191 to 200 of about 2,326 (226)

Guilt by association: EcDNA as a mobile transactivator in cancer

Trends in Cancer, 2022
Extrachromosomal DNA (ecDNA), first described in the 1960s, is emerging as a prevalent but poorly characterized oncogenic alteration in cancer. ecDNA is a reservoir for oncogene amplification and is associated with an aggressive tumor phenotype and poor patient outcome.
Yanfen Zhu, Liang Gong, Chia-Lin Wei
openaire   +3 more sources

ecDNA party bus: Bringing the enhancer to you

Molecular Cell, 2021
Recent work from Zhu et al. (2021) reveals that extrachromosomal DNA circles harboring enhancers can serve as mobile regulatory elements that interact with chromosomal oncogenes, stimulating high-level gene activity and contributing to tumor heterogeneity and cancer progression.
Karen, Adelman, Benjamin J E, Martin
openaire   +2 more sources

Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance.

Molecular Cell
Ashley Nichols, Yujin Choi, R. Norman, Yanyang Chen, Josefine Striepen, Eralda Salataj, Eléonore Toufektchan, R. Koche, J. Maciejowski   +8 more
semanticscholar   +2 more sources

The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance

Cell
Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks and replication defects throughout interphase, how chromosomes undergo shattering remains unresolved.
Justin L. Engel, Xiao Zhang, Mingming Wu, Yan Wang, Jose Espejo Valle-Inclán, Qing Hu, Kidist S. Woldehawariat, Mathijs A. Sanders, A. Smogorzewska, Jin Chen, I. Cortés-Ciriano, Roger S. Lo, Peter Ly   +12 more
semanticscholar   +5 more sources

Methods, bioinformatics tools and databases in ecDNA research: An overview

Computers in Biology and Medicine, 2023
Extrachromosomal DNA (ecDNA), derived from chromosomes, is a cancer-specific circular DNA molecule. EcDNA drives tumor initiation and progression, which is associated with poor clinical outcomes and drug resistance in a wide range of cancers. Although ecDNA was first discovered in 1965, tremendous technological revolutions in recent years have provided
Xinyu Zhao, Huan Zhao, Yupeng Liu, Zhiyun Guo   +3 more
openaire   +2 more sources

MED1-driven ecDNA super-enhancers in cancer.

Cancer Cell
Jiaqi Zhou, Xing Kang, Yang Zhang, Haiyun Gan   +3 more
semanticscholar   +2 more sources

Immortalization and transformation of primary cells mediated by engineered ecDNAs

2023
ABSTRACTFocal gene amplifications are among the most common cancer-associated mutations, but their evolution and contribution to tumorigenesis have proven challenging to recapitulate in primary cells and model organisms. Here we describe a general approach to engineer large (>1 Mbp) focal amplifications mediated by extrachromosomal circular DNAs ...
Davide Pradella, Minsi Zhang, Rui Gao, Melissa A. Yao, Katarzyna M. Gluchowska, Ylenia Cendon Florez, Tanmay Mishra, Gaspare La Rocca, Moritz Weigl, Ziqi Jiao, Hieu H.M. Nguyen, Felix Grimm, Marta Lisi, Chiara Mastroleo, Kevin Chen, Jens Luebeck, Vineet Bafna, Cristina R. Antonescu, Andrea Ventura   +18 more
openaire   +2 more sources

Boundless Bio to tackle ecDNA biology

C&EN Global Enterprise, 2019
Boundless Bio has formally launched with $46.4 million in funding from Arch Venture Partners and City Hill Ventures.
openaire   +1 more source

Abstract 1612: Timing ecDNA acquisition across cancer

Cancer Research
Abstract Extrachromosomal DNA (ecDNA) are acentric, circular DNA fragments which form after DNA double strand breaks. They segregate randomly during mitosis, promoting high-level amplifications of positively selected oncogenes such as EGFR and MYC. The prevalence of ecDNA across several cancer types, such as glioblastoma and sarcoma, has
Andrew R. Lynch, Peter Van Loo
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Shedding Light on ecDNA Behavior Using CRISPR-Based Live-Cell Imaging

Cancer Discovery, 2022
Abstract Summary: Extrachromosomal oncogene amplification on extrachromosomal DNA (ecDNA) has emerged as a hallmark of many cancers. In this issue, Yi and colleagues developed a CRISPR-based method for imaging ecDNA in live cells, termed ecTag.
openaire   +2 more sources