Results 201 to 210 of about 2,028 (216)

Abstract 3501: Concurrent amplification of TBXT and highly activated enhancers in extrachromosomal DNA (ecDNA) drives chordoma tumorigenesis

Cancer Research
Chordoma, a rare bone cancer characterized by limited actionable clinical targets, exhibits a pivotal hallmark in the activation of the developmental transcription factor gene TBXT (Brachyury) through its association with highly active enhancers.
Bo Zhao, Martin Barrio Ines, Lingqun Ye, Xizi Wu, A. Soragni, Andrew Futreal, Kadir C Akdemir   +6 more
semanticscholar   +1 more source

The presence of tumor extrachomosomal circular DNA (ecDNA) as a component of liquid biopsy in blood

Medical Hypotheses, 2018
In molecular biology covalently closed circular DNAs are able to passthrough double layer of eukaryotic cellular membrane. Very recently the presence of circular extra chromosomal DNA (ecDNA) has been shown which are different in seventeen different types of cancers. In fact, ecDNA are the tricky way of oncogenes to increase their copy number.
Fatemeh Khatami, Bagher Larijani, Seyed Mohammad Tavangar   +2 more
openaire   +3 more sources

Inhibition of novel human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer

Research Square
Extrachromosomal circular DNA (ecDNA) have been found in most types of human cancers, and ecDNA incorporating viral genomes has recently been described, specifically in human papillomavirus (HPV)-mediated oropharyngeal cancer (OPC).
Joseph Califano, Takuya Nakagawa, J. Luebeck, Kaiyuan Zhu, Joshua T. Lange, Roman Sasik, Chad Phillips, S. Sadat, Sara Javadzadeh, Qian Yang, Allen Wang, Kersi Pestonjamasp, Sara Rosenthal, Kathleen M Fisch, P. Mischel, V. Bafna   +15 more
semanticscholar   +1 more source

Boundless Bio to tackle ecDNA biology

C&EN Global Enterprise, 2019
Boundless Bio has formally launched with $46.4 million in funding from Arch Venture Partners and City Hill Ventures.
openaire   +2 more sources

Abstract IA017: Extrachromosomal DNA (ecDNA): Cancer’s dynamic circular genome

Cancer Research
Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting genes and regulatory elements can free themselves from chromosomes and relocate to circular, extrachromosomal pieces of DNA (ecDNA).
P. Mischel
semanticscholar   +1 more source

Abstract 3365: Reliable detection of potentially therapeutically actionable ecDNA using clinical-grade NGS in a large pan-cancer cohort

Cancer Research
Background Focal high-level oncogene amplifications (FH-amp) (e.g., MYC, EGFR) frequently occur on extrachromosomal DNA (ecDNA), highly transcribed units of circular non-chromosomal DNA.
Matteo Repetto, Klaus Wagner, Shalabh Suman, P. Krein, Pavitra Rao, M. Arcila, Christian A Hassig, M. Donoghue, A. Drilon, Michael F. Berger   +9 more
semanticscholar   +1 more source

Abstract PR014: PVT1 fusion on extrachromosomal DNA (ecDNA) increases oncogene RNA stability and cancer cell growth

Molecular Cancer Therapeutics
Extrachromosomal DNA (ecDNA), highly amplified circular DNA, is widespread in human cancers and serves as a primary location for oncogene amplification.
Hyerim Yi, Shu Zhang, Matthew G. Jones, J. Belk, Jason Swinderman, Quanming Shi, Ellis J Curtis, Vishnupriya Kanakaveti, P. Mischel, Howard Y. Chang   +9 more
semanticscholar   +1 more source

Abstract 369: In silico investigation of hypoxia and its association with disease outcome and ecDNA detection in TRACERx

Cancer Research
Tumors exhibit dynamic gradients of oxygen diffusion and consumption leading to regions of hypoxia. The presence of hypoxia is associated with poor clinical prognosis and elevated genomic instability. Genes can be amplified extrachromosomally as ecDNA,
Natasha Sharma, Chris Bailey, Corentin Richard, Jeanette Kittel, W. K. Liu, Alexandar M. Frankell, Georgia Satvrou, David A. Moore, Monica Sivakumar, Mariam Jamal Hanjani, C. Swanton, Nnennya Kanu   +11 more
semanticscholar   +1 more source

Abstract 613: Oral CHK1 inhibitor BBI-355 allows flexibility of dose and schedule with demonstration of monotherapy and combinational antitumor activity in extrachromosomal DNA (ecDNA) driven preclinical models

Cancer Research
Focal, high copy number amplifications of prevalent oncogenes (e.g., MYC, EGFR) frequently occur on extrachromosomal DNA (ecDNA), highly transcribed units of circular, non-chromosomal DNA.
Ryan J. Hansen, Auzon Steffy, Joshua Plum, Ardalan Ardeshiri, Edison Tse, Salvador Garcia, Ben Norman, Jafar Moininazeri, A. Pferdekamper, Evan Holmes, Debbie Liao, Rachelle Elsdon, Joshua Lange, Anthony B Pinkerton, Julius Apuy, Sudhir Chowdhry, Christian A Hassig, S. Kasibhatla   +17 more
semanticscholar   +1 more source

ecDNA Inheritance Supports Tumor Heterogeneity and Evolution

Cancer Discovery, 2022
Abstract Segregation of extrachromosomal DNA (ecDNA) is random and leads to extensive copy-number heterogeneity.
openaire   +1 more source