Results 201 to 210 of about 2,326 (226)

The DDR pathway: a critical therapeutic target for ecDNA-positive tumors

Medicine Plus
Huanbo Zhu, Yuan Ding
semanticscholar   +2 more sources

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Satellite DNA fragility accompanies complex genome rearrangements and ecDNA oncogene amplification in canine osteosarcomas

bioRxiv
Canine osteosarcoma (OS) is an aggressive bone cancer with remarkable similarity to human OS. Despite its value as a comparative oncology model, the drivers of genomic instability remain poorly defined, hindering cross-species insights into disease ...
F. Yilmaz, Wonyoung Kong, Sabriya A. Syed, Francis H. O’Neill, Jody T. Lombardi, P. K. Ng, Ching C. Lau, Charles Lee   +7 more
semanticscholar   +1 more source

Effect of extrachromosomal DNA (ecDNA) on MYCN amplified neuroblastoma and patient outcomes.

Journal of Clinical Oncology
3090 Background: Recurrent cytogenetic abnormalities represent candidate therapeutic targets for children with neuroblastoma (NB). MYCN oncogene amplification is associated with significantly worse survival rates for children with NB and ...
Mihika Sonalkar, Carla Sampaio, Ting Yang, Taelor Getz, Catherine Shaw, Vicky Pham, Joshua Lange, Sudhir Chowdhry, Christian A Hassig, Ludmil B. Alexandrov, Peter E. Zage   +10 more
semanticscholar   +1 more source

Abstract SY03-02: Extrachromosomal DNA (ecDNA): Cancer's dynamic circular genome

Cancer Research, 2022
Abstract Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting genes and regulatory elements can free themselves from chromosomes and relocate to circular, extrachromosomal pieces of DNA (ecDNA). ecDNA poses one of the greatest challenges for cancer patients, affecting children and adults and women and men ...
openaire   +1 more source

Abstract 7504: Integrated multiomic analysis to infer longitudinal patterns of ecDNA in IDH-wildtype integrated multiomic analysis to infer longitudinal patterns of ecDNA in IDH wild-type glioblastoma

Cancer Research
Extrachromosomal DNA (ecDNA), a prevalent mechanism of gene amplification, drives oncogene overexpression and is associated with poor patient survival. Over 60% of primary glioblastoma (GBM) cases harbor ecDNA-mediated oncogene amplifications.
Dacheng Zhao, K. Anderson, Amit Gujar, Megan L Costa, D. Nehar-Belaid, F. Varn, Elise T. Courtois, Paul Gabrie, Paul Robson, H. Moon, A. Gołȩbiewska, S. Paek, S. Niclou   +12 more
semanticscholar   +1 more source

Abstract 3900: Integrating single-molecule localization microscopy and computational pipelines to elucidate ecDNA dynamics

Cancer Research
Extrachromosomal DNA (ecDNA) is prevalent across various cancer types, notably Glioblastoma Multiforme (GBM), where it facilitates the rapid acquisition of high oncogene copy numbers by cancer cells.
Mesut Unal, Jessica Alsing, Gabrielle S. Dewson, Guy Nir, Kadir C Akdemir   +4 more
semanticscholar   +1 more source

Abstract 1502: Hypoxia-driven genomic instability and EcDNA formation in lung cancer: insights from TRACERx

Cancer Research
Tumors exhibit dynamic oxygen gradients, leading to hypoxia, which is linked to poor prognosis and genomic instability. The molecular features of hypoxia and their role in lung cancer outcomes remain unclear.
Natasha Sharma, Chris Bailey, Corentin Richard, Jeanette Kittle, C. Swanton, M. Jamal-Hanjani, N. Kanu   +6 more
semanticscholar   +1 more source

Role of ecDNA at Distinct Evolutionary Stages during Pancreatic Carcinogenesis

HPB
M. Felsenstein, D. Ma, J. Tamboli, T. Malinka, J. Pratschke   +4 more
semanticscholar   +2 more sources

Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer

bioRxiv
Extrachromosomal DNAs (ecDNAs), which replicate and segregate in a non-Mendelian manner, serve as vectors for accelerated tumor evolution. By integrating chromatin accessibility, whole-genome sequencing, and Hi-C-based genome topology data from a cohort ...
Lisanne Mout, Thaidy Moreno-Rodriguez, Giacomo Grillo, Ankita Nand, Tina Keshavarzian, S. Bahl, Komaldeep Kang, M. Bootsma, Emma Minnee, Stanley Zhou, Kathleen H. Burns, E. Corey, Peter S. Nelson, S. Dehm, Shuang G. Zhao, W. Zwart, Felix Y. Feng, D. Quigley, M. Lupien   +18 more
semanticscholar   +1 more source

Targeting Extrachromosomal DNA (ecDNA) in Cancer: A New Era of CHK1 Inhibition and Personalized Treatments.

Current Gene Therapy

Komal, Lovekesh Singh, Subramanyam Sarma Ganti   +2 more
semanticscholar   +1 more source