Results 211 to 216 of about 2,028 (216)

Mitotic transcription ensures ecDNA inheritance through chromosomal tethering

SUMMARYExtrachromosomal DNA (ecDNA) are circular DNA bodies that play critical roles in tumor progression and treatment resistance by amplifying oncogenes across a wide range of cancer types. ecDNA lack centromeres and are thus not constrained by typical Mendelian segregation, enabling their unequal accumulation within daughter cells and associated ...
Ashley, Nichols, Roshan, Norman, Yanyang, Chen, Yujin, Choi, Josefine, Striepen, Eralda, Salataj, Eleonore, Toufektchan, Richard, Koche, John, Maciejowski   +8 more
openaire   +2 more sources

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs

SummaryExtrachromosomal DNA (ecDNA) amplifications are prevalent drivers of human cancers. We show that ecDNAs exhibit elevated structural variants leading to gene fusions that produce oncogene fusion transcripts. The long noncoding RNA (lncRNA) genePVT1is the most recurrent structural variant across cancer genomes, withPVT1-MYCfusions arising most ...
Hyerim, Yi, Shu, Zhang, Jason, Swinderman, Yanbo, Wang, Vishnupriya, Kanakaveti, King L, Hung, Ivy Tsz-Lo, Wong, Suhas, Srinivasan, Ellis J, Curtis, Aarohi, Bhargava-Shah, Rui, Li, Matthew G, Jones, Jens, Luebeck, Yanding, Zhao, Julia A, Belk, Katerina, Kraft, Quanming, Shi, Xiaowei, Yan, Simon K, Pritchard, Frances M, Liang, Dean W, Felsher, Luke A, Gilbert, Vineet, Bafna, Paul S, Mischel, Howard Y, Chang   +24 more
openaire   +2 more sources

Startup tackles oncogene-rich ecDNA

Nature Biotechnology, 2022
openaire   +1 more source

APOBEC3-Mediated Mutations Promote CCND1 ecDNA Biogenesis in Bladder Cancer

Cancer Discovery

semanticscholar   +1 more source

1198P Analytical validation of an NGS panel-based ecDNA detection device for use as a clinical trial assay for the POTENTIATE clinical study of the novel CHK1 inhibitor, BBI-355

Annals of Oncology
P. Julien, D. Lu, J. Bieler, T. Zimmermann, E. Magrinelli, J. Wahl, A.C. Tuck, P. Krein   +7 more
semanticscholar   +1 more source

IDDF2024-ABS-0202 Multi-omics profiling reveals characteristics and associations of gastric cancer with extrachromosomal DNA (ecDNA) and drug resistance

Basic Gastroenterology
Jia-Xin Yong, Zhao-Lei Zeng
semanticscholar   +1 more source