Results 211 to 220 of about 2,326 (226)

Association of ERBB2 extrachromosomal DNA (ecDNA) with first-line HER2-targeted treatment outcomes in advanced esophagogastric adenocarcinoma (EGC).

Journal of Clinical Oncology
4041 Background: ecDNA-enabled amplification of oncogenes is associated with increased expression and poor prognosis and is believed to contribute to treatment resistance.
Charlton Tsai, Shalabh Suman, Cynthia Chu, Joanne F. Chou, P. Krein, M. Capanu, D. Ilson, G. Ku, Y. Janjigian, A. Drilon, Michael F. Berger, S. Maron   +11 more
semanticscholar   +1 more source

Startup tackles oncogene-rich ecDNA

Nature Biotechnology, 2022
openaire   +1 more source

Abstract 5870: Taxane-based chemotherapy leads to acquired resistance through ecDNA-based amplification of multi-drug resistance genes

Cancer Research
Focal amplification on extrachromosomal DNA (ecDNA) drives high gene copy number and intercellular genomic heterogeneity, which can fuel tumor adaptation and drug resistance.
Kristen Holmes, Dean Perusse, Cory DuPai, Homa Hemmati, Julie Weiss, Claire Kuelbs, John Bibay, Joan Chen, Debbie Liao, Christian A Hassig, S. Kasibhatla   +10 more
semanticscholar   +1 more source

Abstract 613: Oral CHK1 inhibitor BBI-355 allows flexibility of dose and schedule with demonstration of monotherapy and combinational antitumor activity in extrachromosomal DNA (ecDNA) driven preclinical models

Cancer Research
Focal, high copy number amplifications of prevalent oncogenes (e.g., MYC, EGFR) frequently occur on extrachromosomal DNA (ecDNA), highly transcribed units of circular, non-chromosomal DNA.
Ryan J. Hansen, Auzon Steffy, Joshua Plum, Ardalan Ardeshiri, Edison Tse, Salvador Garcia, Ben Norman, Jafar Moininazeri, A. Pferdekamper, Evan Holmes, Debbie Liao, Rachelle Elsdon, Joshua Lange, Anthony B Pinkerton, Julius Apuy, Sudhir Chowdhry, Christian A Hassig, S. Kasibhatla   +17 more
semanticscholar   +1 more source

Abstract IA017: Extrachromosomal DNA (ecDNA): Cancer’s dynamic circular genome

Cancer Research
Abstract Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting genes and regulatory elements can free themselves from chromosomes and relocate to circular, extrachromosomal pieces of DNA (ecDNA). ecDNA poses one of the greatest challenges for cancer patients, affecting children and adults and women and men ...
openaire   +1 more source

Using Computer Vision Deep Learning Models to Detect ecDNA

ecDNA are small extrachromosomal DNA created by excess DNA damage of the linear genomes. These particles often replicate proto-oncogenes and thus are shown to result in and increase in drug-resistant cancers. The current method of studying ecDNA and the effects various therapies have on the ecDNA count and quality is by using FISH (Fluorescence In-Situ
openaire   +1 more source

Vitamin D promotes DNase1L3 to degrade ecDNA and inhibit the malignant progression of hepatocellular carcinoma

bioRxiv
Heng Zhang, Lu-ning Qin, Qing-qing Li, Ting Wu, Lei Zhang, Kai-wen Wang, Shan-bin Cheng, Yue Shi, Yi-qian Feng, Jing-xia Han, Yi-nan Li, Zhi-yang Li, Hui-juan Liu, Tao Sun   +13 more
semanticscholar   +1 more source

Targeting ATM kinase: a promising strategy to disrupt ecDNA maintenance in cancer

Genome Instability & Disease
Zhuoyang Zhao, Shunichi Takeda
semanticscholar   +1 more source

Faculty Opinions recommendation of ecDNA hubs drive cooperative intermolecular oncogene expression.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2022
openaire   +1 more source

Boundless Bio raises $100 million to advance ecDNA-directed therapies

Chemical & Engineering News, 2023
openaire   +1 more source