Results 21 to 30 of about 2,028 (216)
ecDNA hubs drive cooperative intermolecular oncogene expression [PDF]
Nature, 2021 Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation1. Gene induction typically involves cis-regulatory elements that contact and activate genes on the same chromosome2,3.
King L. Hung +33 more
semanticscholar +8 more sources
Circular ecDNA promotes accessible chromatin and high oncogene expression [PDF]
Nature, 2019 Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer1,2, but our understanding of the structure of ecDNA and its effect on gene regulation is limited. Here, by integrating ultrastructural imaging, long-range optical mapping and computational analysis of whole-genome sequencing, we demonstrate the structure of circular
Sihan Wu +32 more
semanticscholar +5 more sources
Pioneering insights of extrachromosomal DNA (ecDNA) generation, action and its implications for cancer therapy [PDF]
International Journal of Biological Sciences, 2022 Extrachromosomal DNA (ecDNA) is a cancer-specific circular DNA molecule that is derived from chromosomes. In contrast with linear chromosomes, ecDNA exhibits a unique structure that can be representative of high chromosome accessibility, contributing to ...
Ze‐Sheng Li +3 more
semanticscholar +4 more sources
Guilt by association: EcDNA as a mobile transactivator in cancer
Trends in Cancer, 2022 Extrachromosomal DNA (ecDNA), first described in the 1960s, is emerging as a prevalent but poorly characterized oncogenic alteration in cancer. ecDNA is a reservoir for oncogene amplification and is associated with an aggressive tumor phenotype and poor patient outcome.
Yanfen Zhu, Liang Gong, Chia‐Lin Wei
semanticscholar +6 more sources
Nucleic Acids Research, 2023 Human papillomavirus (HPV) integration is a critical step in cervical cancer development; however, the oncogenic mechanism at the genome-wide transcriptional level is still poorly understood. In this study, we employed integrative analysis on multi-omics
R. Tian +16 more
semanticscholar +3 more sources
ecDNA replication is disorganised and vulnerable to replication stress
AbstractExtrachromosomal DNA (ecDNA) is a critical driver of cancer progression, contributing to tumour growth, evolution, and therapeutic resistance through oncogene amplification. Despite its significance, the replication of ecDNA remains poorly understood.
Jaworski JJ +5 more
europepmc +3 more sources
Plasma Concentrations of Extracellular DNA in Acute Kidney Injury [PDF]
Diagnostics, 2020 Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma.
Jordanka Homolová +6 more
doaj +4 more sources
Chromatin-associated RNA Dictates the ecDNA Interactome in the Nucleus
bioRxiv, 2023 Extrachromosomal DNA (ecDNA) promotes cancer by driving copy number heterogeneity and amplifying oncogenes along with functional enhancers. More recent studies suggest two additional mechanisms for further enhancing their oncogenic potential, one via ...
Zhengyu Liang +7 more
semanticscholar +3 more sources
ecPath detects ecDNA in tumors from histopathology images
bioRxivCircular extrachromosomal DNA (ecDNA) can drive tumor initiation, progression and resistance in some of the most aggressive cancers and is emerging as a promising anti-cancer target.
Mudra Choudhury +21 more
semanticscholar +3 more sources
Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance [PDF]
Biochemical Society Transactions, 2022 The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not found in normal cells. Analysis of clinical samples reveal they are common in most cancers and their presence indicates poor prognosis.
L. Pecorino +3 more
semanticscholar +4 more sources