Results 21 to 30 of about 2,326 (226)

Insight on ecDNA-mediated tumorigenesis and drug resistance [PDF]

Heliyon
Extrachromosomal DNAs (ecDNAs) are a pervasive feature found in cancer and contain oncogenes and their corresponding regulatory elements. Their unique structural properties allow a rapid amplification of oncogenes and alter chromatin accessibility ...
Qing Huang, Su Zhang, Guosong Wang, Junhong Han   +3 more
doaj   +4 more sources

Imaging extrachromosomal DNA (ecDNA) in cancer [PDF]

Histochemistry and Cell Biology
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of oncogene amplification, and correlate with treatment resistance and poor prognosis. Consequently, there is great interest in exploring
Karin Purshouse, Steven M. Pollard, Wendy A. Bickmore   +2 more
semanticscholar   +8 more sources

Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

eLife
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna   +6 more
doaj   +3 more sources

MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. [PDF]

Nature
Intratumour heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance1,2. Oncogene dosage variation contributes to cell-state transitions and phenotypic heterogeneity3, thereby providing a substrate for somatic evolution ...
Fiorini E, Malinova A, Schreyer D, Pasini D, Bevere M, Alessio G, Rosa D, D'Agosto S, Azzolin L, Milite S, Andreani S, Lupo F, Veghini L, Grimaldi S, Pedron S, Castellucci M, Nourse C, Salvia R, Malleo G, Ruzzenente A, Guglielmi A, Milella M, Lawlor RT, Luchini C, Agostini A, Carbone C, Pilarsky C, Sottoriva A, Scarpa A, Tuveson DA, Bailey P, Corbo V.   +31 more
europepmc   +5 more sources

Oncogene Silencing via ecDNA Micronucleation [PDF]

bioRxiv
Extrachromosomal DNA (ecDNA) is a common source of oncogene amplification across many types of cancer. The non-Mendelian inheritance of ecDNA contributes to heterogeneous tumour genomes that rapidly evolve to resist treatment. Here, using single-cell and
Brückner L, Xu R, Tang J, Herrmann A, Wong IT, Zhang S, Tu F, Pilon M, Kukalev A, Pardon K, Sidorova O, Atta J, Yu Q, Pradella D, Ilić M, Novais-Cruz M, Kaltenbach S, Treue D, Giurgiu M, Herzog S, Hollinger A, Fernandez M, Becker F, Louma V, Schmargon R, Dörr J, Gamlin D, Lehmann A, Gürgen D, Richter M, Dubois F, Simeoni F, Pennycook BR, Hamilton A, Lindemann RK, Fischer M, Bafna V, Wahl G, Koche RP, Chang HY, Papathanasiou S, Medema R, Spanjaard B, Ventura A, Pombo A, Huang W, Werner B, Mischel PS, Henssen AG.   +48 more
europepmc   +4 more sources

ecPath detects ecDNA in tumors from histopathology images [PDF]

bioRxiv
Circular extrachromosomal DNA (ecDNA) can drive tumor initiation, progression and resistance in some of the most aggressive cancers and is emerging as a promising anti-cancer target.
Mudra Choudhury, Lihe Liu, Anamika Yadav, Owen Chapman, Zahra Ahmadi, Raneen Younis, Chinmay Sharma, Navansh Goel, Sunita Sridhar, Rishaan Kenkre, Aditi Dutta, Shanqing Wang, Eldad D. Shulman, Saugato Rahman Dhruba, Danh-Tai Hoang, Kevin M. Tharp, Megan Paul, Denise Malicki, Kevin Y. Yip, Eytan Ruppin, Lukas Chávez, Sanju Sinha   +21 more
semanticscholar   +3 more sources

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells [PDF]

eLife, 2022
Extrachromosomal DNA (ecDNA) are frequently observed in human cancers and are responsible for high levels of oncogene expression. In glioblastoma (GBM), ecDNA copy number correlates with poor prognosis.
Karin Purshouse, Elias T Friman, Shelagh Boyle, Pooran Singh Dewari, Vivien Grant, Alhafidz Hamdan, Gillian M Morrison, Paul M Brennan, Sjoerd V Beentjes, Steven M Pollard, Wendy A Bickmore   +10 more
doaj   +4 more sources

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs

bioRxiv
SummaryExtrachromosomal DNA (ecDNA) amplifications are prevalent drivers of human cancers. We show that ecDNAs exhibit elevated structural variants leading to gene fusions that produce oncogene fusion transcripts. The long noncoding RNA (lncRNA) genePVT1is the most recurrent structural variant across cancer genomes, withPVT1-MYCfusions arising most ...
Hyerim Yi, Shu Zhang, Jason Swinderman, Yanbo Wang, Vishnupriya Kanakaveti, King L. Hung, Ivy Tsz-Lo Wong, Suhas Srinivasan, Ellis J. Curtis, Aarohi Bhargava-Shah, Rui Li, Matthew G. Jones, Jens Luebeck, Yanding Zhao, Julia A. Belk, Katerina Kraft, Quanming Shi, Xiaowei Yan, Stuart C. Pritchard, Fei Liang, Dean W. Felsher, Luke A. Gilbert, Vineet Bafna, Paul S. Mischel, Howard Y. Chang   +24 more
semanticscholar   +5 more sources

ATACAmp: a tool for detecting ecDNA/HSRs from bulk and single-cell ATAC-seq data [PDF]

BMC Genomics, 2023
Background High oncogene expression in cancer cells is a major cause of rapid tumor progression and drug resistance. Recent cancer genome research has shown that oncogenes as well as regulatory elements can be amplified in the form of extrachromosomal ...
Hansen Cheng, Wenhao Ma, Kun Wang, Han Chu, Guangchao Bao, Yu Liao, Yawen Yuan, Yixiong Gou, Liting Dong, Jian Yang, Haoyang Cai   +10 more
doaj   +2 more sources

Histone 3 lysine 56 acetylation (H3K56ac) regulates extrachromosomal DNA (ecDNA) hub maintenance [PDF]

Neoplasia: An International Journal for Oncology Research
Extrachromosomal DNAs (ecDNAs) play an important role in tumor progression. ecDNA hubs have been shown to be anchored by BRD4, a chromatin reader. However, the chromatin organization of ecDNA hub remains unknown.
Li-Zhu Liao, Chang-Jiun Wu, Yu-An Chen, Tzu-Chin Lin, Po-Hung Lin, Chia-Lin Wei, Kou-Juey Wu   +6 more
doaj   +2 more sources