Results 31 to 40 of about 2,028 (216)

EcDNA hubs drive cooperative intermolecular oncogene expression [PDF]

bioRxiv, 2020
Extrachromosomal DNAs (ecDNAs) are prevalent in human cancers and mediate high oncogene expression through elevated copy number and altered gene regulation1.
King L. Hung, K. Yost, Liangqi Xie, Quanming Shi, K. Helmsauer, J. Luebeck, R. Schöpflin, Joshua T. Lange, R. Chamorro González, Natasha E Weiser, Celine Y. Chen, Maria E. Valieva, I. Wong, Sihan Wu, S. R. Dehkordi, Connor V. Duffy, K. Kraft, Junfang Tang, J. Belk, John C. Rose, M. Corces, Jeffrey M. Granja, Rui Li, Utkrisht Rajkumar, Jordan Friedlein, A. Bagchi, Ansuman T. Satpathy, R. Tjian, S. Mundlos, V. Bafna, A. Henssen, P. Mischel, Zhe J. Liu, Howard Y. Chang   +33 more
semanticscholar   +3 more sources

Leveraging AI to Automate Detection and Quantification of Extrachromosomal DNA (ecDNA) to Decode Drug Responses [PDF]

bioRxiv
AbstractTraditional drug discovery efforts have largely focused on targeting rapid, reversible protein-mediated adaptations to undermine cancer cells’ resistance to therapy. However, cancer cells also exploit DNA-based strategies, typically viewed as slow, irreversible, and unpredictable changes like point mutations or the selection of drug-resistant ...
Kohen Goble, Aarav Mehta, Damien Guilbaud, J H Fessler, Jingting Chen, William Nenad, Oliver Cope, David S. Cheng, William C. Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk   +12 more
semanticscholar   +4 more sources

microDNA and ecDNA: Current methods and single-cell sequencing

Computational and Structural Biotechnology Journal, 2023
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from genomic DNA but are separate from chromosomes. They are common in various organisms, with sizes ranging from a few hundred to millions of base pairs. A special type of large extrachromosomal DNA (ecDNA) is prevalent in cancer cells.
Rong Jiang, Manqiu Yang, Shufan Zhang, Moli Huang   +3 more
semanticscholar   +5 more sources

Extracellular DNA and Deoxyribonuclease Activity as Prognostic Markers in Sepsis [PDF]

Biomedicines
Background/Objectives: Sepsis is characterized by a dysregulated immune response to infection and is associated with high lethality. Extracellular DNA (ecDNA) has drawn significant interest as a damage-associated molecular pattern because of its ...
Monika Janíková, Nikola Pribulová, Katarína Kmeťová, Kristína Macáková, Anna Dobišová, Michaela Kopčová, Mária Bucová, Barbora Vlková, Peter Celec   +8 more
doaj   +2 more sources

The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance

Cell
Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks and replication defects throughout interphase, how chromosomes undergo shattering remains unresolved.
Justin L. Engel, Xiao Zhang, Mingming Wu, Yan Wang, Jose Espejo Valle-Inclán, Qing Hu, Kidist S. Woldehawariat, Mathijs A. Sanders, A. Smogorzewska, Jin Chen, I. Cortés-Ciriano, Roger S. Lo, Peter Ly   +12 more
semanticscholar   +4 more sources

Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate-resistant human colorectal cancer cells

International Journal of Oncology, 2023
Extrachromosomal DNAs (ecDNAs), also known as double minutes (DMs), can induce a fast increase in gene copy numbers and promote the development of cancer, including drug resistance.
Xu Wang, Yanan Qu, Ruonan Xing, Jing Zhou, Yanghe Liu, Huishu Zhang, Jing Zhu, Jinfa Ma, Xiaobo Cui, Tiantian Song, Shukai Xing, G. Ji, Peng Liu, Wenjing Sun, Songbin Fu, Xiangning Meng   +15 more
semanticscholar   +3 more sources

Whole genome sequencing revealed esophageal squamous cell carcinoma related biomarkers. [PDF]

PLoS ONE
Esophageal squamous cell carcinoma (ESCC) is among the most frequently diagnosed cancer types, and affected patients frequently experience poor prognostic outcomes and high mortality rates. Many genomic studies of ESCC have been performed in recent years,
Mingjun Li, Lei Li, Xizi Wang, Yanwei Zhao, Peina Du, Wei Wang, Zhenxing Wang, Yadong Wang, Yanxing Sheng, Mingliang Gu, Xiaodong Jia   +10 more
doaj   +2 more sources

MEDB-33. The landscape of ecDNA in medulloblastoma [PDF]

Neuro-Oncology, 2022
Abstract Extrachromosomal circular DNA (ecDNA) is an important driver of aggressive cancers, including medulloblastoma (MB), the most common malignant pediatric brain tumor. To assess the clinical importance of ecDNA in MB, we applied computational methods to detect ecDNA in the genomes of a cohort of 468 MB patients and 31 MB model ...
Owen Chapman, Sunita Sridhar, Shanqing Wang, Jon D. Larson, Robert J. Wechsler‐Reya, Jill P. Mesirov, Lukas Chávez   +6 more
openalex   +2 more sources

ecDNA replication is disorganized and vulnerable to replication stress. [PDF]

Nucleic Acids Res
Jaworski JJ, Pfuderer PL, Czyz P, Petris G, Boemo MA, Sale JE.   +5 more
europepmc   +2 more sources

Pan-cancer characterization and clinical outcome of ecDNA-enhancer mediated transcriptional dysregulation [PDF]

bioRxiv, 2023
Extrachromosomal circular DNAs (ecDNAs) are extrachromosomal circular DNA elements harboring enhancers that can function as mobile transcriptional enhancers to promote oncogene amplification in diverse human cancers.
Tengwei Zhong, Huan Zhao, Yupeng Liu, Danyang Yan, Yuguo Li, Zhiyun Guo   +5 more
openalex   +2 more sources