Extrachromosomal DNA (ecDNA) in cancer: mechanisms, functions, and clinical implications
Frontiers in Oncology, 2023 Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the development and heterogeneity of cancer. The rapid evolution of methods to detect ecDNA, including microscopic and sequencing approaches, has greatly enhanced our knowledge ...
Yucheng Dong +5 more
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Plasma Concentrations of Extracellular DNA in Acute Kidney Injury [PDF]
Diagnostics, 2020 Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma.
Jordanka Homolová +6 more
doaj +4 more sources
DNA damage response pathway is a promising therapeutic target for extrachromosomal DNA-positive tumours. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Tian C, Gan H.
europepmc +2 more sources
Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes. [PDF]
ScienceGenome instability, including chromothripsis, is a hallmark of cancer. Cancer cells frequently contain micronuclei-small, nucleus-like structures formed by chromosome missegregation-that are susceptible to rupture, exposing chromatin to cytoplasmic ...
Krupina K +18 more
europepmc +2 more sources
Extrachromosomal DNA (ecDNA): Unveiling its role in cancer progression and implications for early detection [PDF]
Heliyon, 2023 Extrachromosomal DNA (ecDNA) is a special class of circular DNA in eukaryotes, which is independent of conventional chromosomes. These circular molecules play important roles in biology, especially in cancer biology.
Shuhong Wu +4 more
doaj +2 more sources
Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution [PDF]
Genome BiologyBackground Genomic alterations are a hallmark of cancer, and extrachromosomal DNA (ecDNA) has emerged as a key source of oncogene selection, tumor growth, and drug resistance. The intratumor heterogeneity and clonal selection of ecDNA is, however, poorly
Josephine Deleuran Hendriksen +9 more
doaj +2 more sources
The role of extrachromosomal DNA in tumorigenesis and progression [PDF]
Frontiers in OncologyIn tumors, extrachromosomal DNA (ecDNA) is an important driver of oncogene expression, genomic instability, the evolution of drug resistance, and poor patient prognosis. ecDNA is present in various tumors but is rarely found in normal cells.
Xiaoyang Ma +7 more
doaj +2 more sources
EXTH-143. Preclinical Efficacy of Brain Penetrant, Single Agent Avapritinib in PDGFRA EcDNA-amplified Glioblastoma [PDF]
Neuro-OncologyThe high prevalence of platelet derived growth factor receptor alpha (PDGFRA) alterations and its mitogenic function in oligodendrocyte precursor cells (OPC) make PDGFRA a promising therapeutic target in adult glioblastoma (GBM).
Artem Berezovsky +10 more
openalex +2 more sources
The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution
NatureAdvanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogeneity1. In this study, we investigated the evolution of genomic signatures caused by endogenous and external mutagenic processes and their interplay with ...
Duy D. Nguyen +33 more
semanticscholar +3 more sources
Not just a by-product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B-cell leukemia. [PDF]
Mol OncolGao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Pradella D, Ventura A.
europepmc +2 more sources